Research Article

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09/29/2014
Ezrin; Laryngeal squamous cell carcinoma; Metastasis; Moesin; Prognosis

We examined the expression of ezrin and moesin in laryngeal squamous cell carcinoma (LSCC) and their correlation with patient clinicopathological characteristics and overall survival. Immunohistochemical staining and reverse transcription-polymerase chain reaction (RT-PCR) for ezrin and moesin were applied to 60 carcinoma tissues, adjacent normal tissues, and 33 metastatic lymph nodes. ... more

X. Wang; M. Liu; C.Y. Zhao
09/12/2014
Maxillary sinus; Metastasis; Renal cell carcinoma

Metastatic tumors in the paranasal sinuses are very rare. The origin of metastatic tumors in the paranasal sinuses is often renal cancer. Renal cell carcinomas are known for their tendency for early metastasis, and symptoms due to the metastatic lesion may be the only initial manifestation. In this paper, we deal with the case of a 35-year-old male patient who presented with a mass in the ... more

Y.F. He; J. Chen; W.Q. Xu; C.S. Ji; J.P. Du; H.Q. Luo; B. Hu
02/28/2013
Biomarker; Muscle-invasive bladder cancer; Pathway analysis; Stroma

To bring about improvements in cancer biology research and elucidate mechanism-based therapeutic targets, we studied the proteome expression profile of purified normal urothelial cells (cancer cells) and normal stromal cells (cancerous stromal cells). Based on the expression profile, biomarker discovery and the mechanisms of multi-step carcinogenesis were explored. We found that 1412/ ... more

H.T. Niu; X.J. Qi; Y.Q. Liu; Y.W. Cao; Q. Dong; X.S. Wang
09/27/2013
Biomarker; Gene polymorphism; Genetics; Non-small cell lung cancer; Survivin

Lung cancer is the most common cancer worldwide. Survivin is one of the first reported inhibitors of apoptosis proteins, which is an important family of proteins that regulate apoptosis. The survivin gene is located on human chromosome 17q25, which is composed of 142 amino acids. A common polymorphism of the survivin gene promoter -31G/C has been shown to influence cancer risk. This ... more

E. Aynaci; E. Coskunpinar; A. Eren; O. Kum; Y.M. Oltulu; N. Akkaya; A. Turna; I. Yaylim; P. Yildiz
11/28/2012
Biomarker; Breast cancer; Human mammaglobin; Prognostic factor

Different treatment outcomes and prognoses in patients with breast cancer can be observed with similar clinical predictors; this is because the biology of breast cancer is complex and heterogenous, involving multiple unknown contributing factors. We looked for plasma human mammaglobin (hMAM) mRNA by RT-PCR in 82 Korean patients with breast cancer to determine if there is an association ... more

G.W. Lee; J.Y. Kim; E.H. Koh; D. Kang; D.S. Choi; K.Y. Maeng; J.S. Lee
01/27/2012
Biomarker; Circulation; Gene expression; Ischemic stroke; MicroRNA-145; Postnatal neovascularization

Cerebral ischemia or ischemic stroke is mainly attributed to vascular and circulation disorders. Among protein biomarkers, RNA profiles have also been identified as markers of ischemic stroke. MicroRNA-145 expression is ostensibly recognized as marker and modulator of vascular smooth muscle cell phenotype; however, expression levels in ischemic stroke had not been investigated. Employing ... more

C.S. Gan; C.W. Wang; K.S. Tan
11/07/2014
Advanced oxidation protein products; Biomarker; Case-control study; Cutaneous lupus erythematosus; Lupus nephritis; Prognosis

Oxidative stress is involved in the pathogenesis of lupus nephritis (LN). The current study investigated the significance of advanced oxidation protein products (AOPPs) as a biomarker of LN in patients with cutaneous lupus erythematosus. Ninety-two patients who initially presented with systemic lupus erythematosus were divided into the LN- and LN+ groups. Serum AOPP levels were determined ... more

Z. Xie; M. Zhang; B. Zhao; Q. Wang; J. Li; Y.Y. Liu; Y.H. Chen
10/31/2014
Biomarker; Chronic obstructive pulmonary disease; Protein-protein interaction network

Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality throughout the world. The purpose of our study was to uncover biomarkers and explore its pathogenic mechanisms at the molecular level. The gene expression profiles of COPD samples and normal controls were downloaded from Gene Expression Omnibus. Matlab was used for data preprocessing and SAM4.0 was ... more

Y.P. Yuan; Y.H. Shi; W.C. Gu
02/02/2015
Aged population; Esophageal carcinoma; Immunotherapy; Radiotherapy

We investigated the clinical efficacy of adoptive cytokine-induced killer (CIK) cell and dendritic cell (DC) therapy plus intensity-modulated radiation therapy (IMRT) for treating elderly patients with esophageal carcinoma (EC). In total, 68 elderly patients with EC were randomized to receive IMRT plus DC-CIK immunotherapy (study group, N = 34) or IMRT only (control group, N = 34). ... more

L. Yan; M. Wu; N. Ba; L.J. Wang; H.Q. Zhang; G.Y. Shi; Z.S. Zhang; X.J. Wang
12/08/2011
Breast cancer; Chondroitin sulfate; Chondroitinase ABC; Metastasis; Orthotopic tumor

Breast cancer is one of the leading causes of cancer-related deaths amongst women in the USA. The tumor microenvironment has been suggested to be an attractive therapeutic target for treatment of cancers. The glycosaminoglycan chondroitin sulfate, as part of the cellular microenvironment, consists of long linear chains of repeating disaccharide units, which are covalently attached to core ... more

R.D. Prinz; C.M. Willis; A. Viloria-Petit; M. Klüppel

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