Research Article

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Familial Mediterranean fever; Gene polymorphism; Glutathione peroxidase; Inflammation; Oxidative stress; Paraoxonase

Familial Mediterranean fever (FMF) is an autosomal recessive disorder and is the most frequent of the periodic febrile inflammatory syndromes. The pathogenesis of the disease is not completely understood, even though the FMF gene has been identified. Oxidative stress and inflammation may play a role in the pathogenesis of FMF. We investigated gene polymorphisms of the antioxidative ... more

F. Öktem; H. Anıl; R. Sütcü; A.E. Kuybulu
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Oxidative stress; Polymorphism; Sickle cell anemia; Superoxide dismutase

Oxidative stress may be contributory to the pathophy­siology of the abnormalities that underlie the clinical course of sickle cell anemia. We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. One hundred and twenty-seven patients with sickle cell anemia and 127 healthy controls were recruited into the ... more

S. Sogut; Z. Yonden; H. Kaya; S. Oktar; M. Tutanc; H.R. Yilmaz; A. Yigit; N. Ozcelik; E. Gali
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Coronary artery disease; Inflammation; Polymorphism; PPAR-δ

Peroxisome proliferator-activated receptor delta (PPAR-δ) is a transcription factor implicated in metabolism and inflammation. The +294T/C polymorphism in the PPAR-δ gene is associated with risk of coronary artery disease (CAD) in dyslipidemic women and hypercholesterolemic men. Whether this polymorphism influences the risk of CAD in the absence of dyslipidemia was not known, so we ... more

I. Jguirim-Souissi; A. Jelassi; Y. Hrira; M. Najah; A. Slimani; F. Addad; M. Hassine; K.B. Hamda; F. Maatouk; M. Rouis; M.N. Slimane
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Chemokine; Gene; Inflammation; OSCC; Polymorphism

We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restricted fragment length polymorphism ( ... more

C.R. Tanyel; Z.B. Cincin; B. Gokcen-Rohlig; K. Bektas-Kayhan; M. Unur; B. Cakmakoglu
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Antioxidant; Expressed sequence tags; Free radicals; Oxidative stress; Paracoccidioides brasiliensis; Transcription factors

Survival of pathogenic fungi inside human hosts depends on evasion from the host immune system and adaptation to the host environment. Among different insults that Paracoccidioides brasiliensis has to handle are reactive oxygen and nitrogen species produced by the human host cells, and by its own metabolism. Knowing how the parasite deals with reactive species is important to ... more

É.G. Campos; Ada Silva Dantas; Mde Macedo Brigido; Mde Macedo Brigido; M.Sueli S. Felipe; R.Santos Amo Jesuino
12/19/2011
hOGG1; Oxidative stress; Polymorphisms; XPD

Knee replacement surgery is an ischemia/reperfusion model, as it uses tourniquet applied to the knee area to stop the blood flow during the operation. Fifty patients that were undergoing elective arthroscopic knee surgery were included in our study. Human 8-oxoguanine glycosylase 1 (hOGG1) is an enzyme to repair specific DNA lesions and a good marker of hydroxyl radical damage to DNA. XPD ... more

O. İsbir; U. Gormus; H.A. Ergen; B. Cakmakoglu; Ö.T. Kahraman; N. Baykan
10/19/2010
Antioxidant; Lipid metabolism genes; Oxidative stress; Thai black sticky rice

Anthocyanins, which are found in some food, including Thai black sticky rice, are reported to have health-promoting properties. Oxidative stress plays a major role in the pathogenesis of many degenerative diseases induced by free radicals, such as cardiovascular disease, stroke and cancer. We evaluated the anthocyanin-rich extract (ARE) from Thai black sticky rice for antioxidative and ... more

W. Sangkitikomol; T. Tencomnao; A. Rocejanasaroj
07/25/2014
Glucose metabolism; Glucose transport; hydrogen peroxide; Oxidative stress; Schizosaccharomyces pombe; Thiamine

The relationship between glucose repression and the oxidative stress response was investigated in Schizosaccharomyces pombe wild type cells (972h-) and glucose repression resistant mutant type cells (ird11). We aimed to reveal the mechanism of simultaneous resistance to glucose repression and oxidative stress in ird11 mutants. ... more

B. Palabiyik; J. Ghods; O. Ucar
05/11/2015
Ascorbate peroxidase; H2O2; Jatropha curcas; Oxidative stress; Salt stress

Ascorbate peroxidase (APX) plays a central role in the ascorbate-glutathione cycle and is a key enzyme in cellular H2O2 me­tabolism. It includes a family of isoenzymes with different character­istics, which are identified in many higher plants. In the present study, we isolated the APX gene from Jatropha curcas L, which is similar with other ... more

Y. Chen; J. Cai; F. .X.Yang; B. Zhou; L.R. Zhou
10/25/2011
CYP2D6*4; HLA-B27; Mutation; Real-time PCR

We analyzed distribution of HLA-B27 and CYP2D6*4 mutations in 249 patients from Tokat province in Turkey with symptoms of arthritis, sacroiliac, joint and back pain, using a LightCycler 480 II Real-Time PCR thermal cycler. The Genes-4U was applied for studying HLA-B27 mutation, and the Tib-Molbiol commercial kit was used to examine the CYP2D6*4 mutation. Among the 249 patients, 18.5% had ... more

S. Sahin; L. Aydogan; I. Benli; H. Ozyurt

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