Research Article

Related GMR Articles

03/12/2014
5-HT; Haplotype; Paranoid schizophrenia; Serotonin; SNP; TPH2

In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nucleotide polymorphisms (SNPs) in the regulatory regions of TPH2 ... more

X.M. Xu; M. Ding; H. Pang; B.J. Wang
12/14/2011
Colorectal cancer risk; Genotype; Haplotype; MTHFR

Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer. We made a case-control study to analyze a possible association of MTHFR gene polymorphisms C677T and A1298C ... more

H. Li; W.L. Xu; H.L. Shen; Q.Y. Chen; L.L. Hui; L.L. Long; X.L. Zhu
12/08/2011
FMF; Haplotype; MDR1; Polymorphism; Turkey

The multidrug resistance (MDR1) gene encodes a P-glycoprotein that plays a key role in drug bioavailability and response to drugs in different human populations. More than 50 SNPs have been described for the MDR1 gene. Familial Mediterranean fever (FMF) is considered an autosomal recessive hereditary disease, associated with a single gene named the Mediterranean fever gene (MEFV). However ... more

A. Rüstemoglu; G. Gümüş-Akay; S. Yigit; T. Tasliyurt
12/10/2013
China (CHB); Chinese Han in Beijing; Haplotype; Linkage disequilibrium; Tibetan; UGT1A

As part of a series of pharmacogenomics studies of the Chinese population, we investigated genetic polymorphisms of some UGT1A regions. The three genes that were analyzed were UGT1A9, 1A7, and 1A1; we sequenced their exons, together with promoters, surrounding introns and 3'-untranslated regions (3ꞌUTR) in 100 unrelated-healthy Chinese Tibetan individuals. We compared the data with ... more

W. Yan; Y.W. Wang; F.F. Yang; M. Wang; X.Q. Zhang; J. Dong; E. Chen; J. Yang
12/06/2012
Haplotype; Male infertility; Single nucleotide polymorphism; UBE2B

The ubiquitin-conjugating enzyme 2B gene (UBE2B) is involved in the regular and symmetric organization of the fibrous sheath of sperm flagella. This study aimed to examine the relationship between single nucleotide polymorphisms (SNPs) in UBE2B and infertility in Northeast Chinese men. We carried out a polymerase chain reaction-restriction fragment length polymorphism ... more

Y. Hu; W. Wen; J.G. Yu; S.Q. Qu; S.S. Wang; J. Liu; B.S. Li; Y. Luo
10/09/2012
HAPE; Haplogroup; Haplotype; Hypoxia; Mitochondrial DNA; mtSNP

High-altitude pulmonary edema (HAPE) is a life-threatening condition caused by acute exposure to high altitude. Accumulating evidence suggests that genetic factors play an important role in the etiology of HAPE. However, conclusions from association studies have been hindered by limited sample size due to the rareness of this disease. It is known that mitochondria are critical for hypoxic ... more

Y.J. Luo; W.X. Gao; S.Z. Li; X.W. Huang; Y. Chen; F.Y. Liu; Q.Y. Huang; Y.Q. Gao
01/09/2012
Chinese Hui population; Haplotype; Polymorphism; Rheumatoid arthritis; TIM-1

The T-cell immunoglobulin and mucin domain 1 (TIM-1) is known to be associated with susceptibility to rheumatoid arthritis (RA). We investigated the association of four single-nucleotide polymorphisms (SNPs) in the promoter region of the TIM-1 gene with susceptibility to RA in a Chinese Hui ethnic minority group. Using RFLP or sequence specific primer-PCR, 118 RA patients and 118 non- ... more

J.R. Xu; Y. Yang; X.M. Liu; J.Y. Sun; Y.J. Wang
11/14/2014
Cattle; Haplotype; Polymorphism; Short tandem repeat; Y-chromosome

The aim of this study is to use Y-chromosome gene polymorphism method to investigate regional differences in genetic variation and population evolution history of the Chinese native cattle breeds. Six Y-chromosome short tandem repeat (Y-STR) loci (UMN0929, UMN0108, UMN0920, INRA124, UMN2404, and UMN0103) were analyzed using 1016 healthy ... more

Y.P. Xin; L.S. Zan; Y.F. Liu; W.Q. Tian; H.B. Wang; G. Cheng; A.N. Li; W.C. Yang
10/27/2014
Haplotype; Kazakh; Linkage disequilibrium; Metabolic syndrome; Polymorphism; PPARγ

We investigated the relationship between haplotype and linkage disequilibrium of the PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 and metabolic syndrome (MS) in the Kazakh people of Xinjiang Province. For PPARγ, rs3856806, rs12490265, rs1797912, and rs1175543 genotypes were detected in 489 subjects (including 245 MS patients and 244 controls) using matrix- ... more

S.X. Guo; H. Guo; R.L. Ma; Y.S. Ding; J.Y. Zhang; J.M. Liu; M. Zhang; Q. Niu; N. Qiang; S.G. Li; C.N. Qi
03/06/2015
Chicken; Haplotype; HSP70; Single nucleotide polymorphism

This study was designed to detect the sequence variation of the chicken heat shock protein 70 (HSP70) gene. A total of 102 individuals from 8 native Chinese breeds together with Dwarf White Chicken and Red Junglefowl were used to detect sequence variations. The coding regions of the chicken HSP70 gene from 102 individuals were cloned and sequenced. Thirty-six variations ... more

J.K. Gan; L.Y. Jiang; L.N. Kong; X.Q. Zhang; Q.B. Luo

Pages