Research Note

Related GMR Articles

03/22/2012
BDNF; DARPP; Restriction fragment length polymorphism; Schizophrenia; SNP

A number of studies have pointed to the association of BDNF (brain-derived neurotrophic factor) and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) with schizophrenia. The purpose of this study was to determine whether these two genes are involved in the pathogenesis of schizophrenia in the Malay population. Two single nucleotide polymorphisms Val66Met of ... more

H.C. Loh; P.Y. Tang; S.F. Tee; T.J. Chow; Y.C. Cheah; S.S.J. Singh
01/31/2012
BMD; Genome-wide association studies; Osteoporotic fractures; SNP

Osteoporosis is a heritable disease characterized mainly by low bone mineral density (BMD) and/or osteoporotic fractures (OF). Most genome-wide association studies on osteoporosis have focused on BMD, whereas little effort has been expended to identify genetic variants directly linked to OF. To determine whether BMD-loci are also associated with OF risk, we performed a validation study to ... more

Y. Guo; J.T. Wang; H. Liu; M. Li; T.L. Yang; X.W. Zhang; Y.Z. Liu; Q. Tian; H.W. Deng
02/16/2012
CLPTM1L; Lung adenocarcinoma; Lung cancer; SNP; TERT

Recent studies have shown that 5p15.33 is one of the chromosomal regions that is most consistently altered in lung cancer; common variants that are located in this region have been genotyped in various populations. However, the genetic contribution of these variants to carcinogenesis is relatively unknown. A clinic-based case-control study in Shanghai was undertaken on 196 patients with ... more

X.F. Chen; S. Cai; Q.G. Chen; Z.H. Ni; J.H. Tang; D.W. Xu; X.B. Wang
08/07/2014
Gestational hypertension; LIPC gene; Lipid metabolism; Preeclampsia; SNP

We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. Clinically defined HDCP patients (N = 321) and healthy pregnant women (N = 331) were recruited and genotyped using polymerase chain reaction- ... more

H. Lin; Z. Yin; X.Y. Yu; N. Lin; Y. Lin; J. Chen; Y.Z. Chen; K.P. Lu; H.K. Liu
05/09/2014
Radixin; Rheumatoid arthritis; SNP

Radixin (RDX) is part of the ezrin-radixin-moesin (ERM) protein family. It functions as a membrane-cytoskeletal linker in actin-rich cell surface structures and is thought to be essential for cortical cytoskeleton organization, cell motility, adhesion, and proliferation. An increase in phosphorylated ERM in fibroblast-like synoviocytes contributes to rheumatoid arthritis (RA) synovial ... more

H.K. Kim; J.S. Joo; H.Y. Lee; J.T. Kwon; D.R. Sohn; S.J. Hong; H.J. Kim
01/24/2014
FOLR1; Genotype; PCR-RFLP; PRLR; SNP

We investigated the polymorphisms of PRLR and FOLR1 genes in Xinong Saanen, Guanzhong, and Boer goat breeds by DNA sequencing and PCR–RFLP. Two novel SNPs were identified: KC109741: g.62130C>T in the 3ꞌ-UTR of goat gene PRLR, and KC136296: g.7884A>C in exon 3 of goat gene FOLR1. In the three goat breeds, the polymorphism information content was 0. ... more

J.X. Hou; F. Fang; X.P. An; Y. Yan; T. Ma; P. Han; F.X. Meng; Y.X. Song; J.G. Wang; B.Y. Cao
03/12/2014
Dopamine; DRD5; Haplotype; Paranoid schizophrenia; SNP

Dopamine (DA) has been implicated in the pathophysiol­ogy of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopa­mine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs) in the regulatory regions of DRD5 gene may affect ... more

Y. Zhao; M. Ding; H. Pang; X.M. Xu; B.J. Wang
03/12/2014
5-HT; Haplotype; Paranoid schizophrenia; Serotonin; SNP; TPH2

In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nucleotide polymorphisms (SNPs) in the regulatory regions of TPH2 ... more

X.M. Xu; M. Ding; H. Pang; B.J. Wang
01/14/2014
Association analysis; Pig; Reproductive trait; RFRP gene; SNP

RFamide-related peptide (RFRP) gene is a crucial gene of the hypothalamo-pituitary-gonadal axis and plays an important role in reproduction regulation. This study aimed to clone and characterize the pig RFRP gene. We obtained a 645-bp cDNA of pig RFRP gene comprising a 546-bp open reading frame, which encoded a peptide of 188 amino acids. The pig RFRP coding ... more

M.X. Fang; Y.S. Huang; J. Ye; W. Zhang; Y. Li; Q.H. Nie
01/10/2014
Breast cancer; Han nationality: PCR-SSCP; SNP; Trinucleotide-repeat-containing 9

A single nucleotide polymorphism (SNP) in the TNRC9 gene was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry. We investigated whether TNRC9 polymorphisms are associated with risk of breast cancer in Chinese women of the Han nationality. We genotyped the SNPs rs3803662, rs1362548, rs1123428 in 870 women, ... more

F. Chen; J. Zhou; Y. Xue; S. Yang; M. Xiong; Y. Li; Q. Liu

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