Research Article

Related GMR Articles

05/12/2015
ATR; Cell cycle; Chk1; HL-60; Mangiferin

This study aimed to determine the effect of mangiferin on the cell cycle in HL-60 leukemia cells and expression of the cell cycle-regulatory genes Wee1, Chk1 and CDC25C and to further investigate the molecular mechanisms of the antileukemic action of mangiferin. The inhibitory effect of mangiferin on HL-60 leukemia cell proliferation was determined by the MTT assay. The impact of ... more

Z.G. Peng; Y.B. Yao; J. Yang; Y.L. Tang; X. Huang
11/16/2010
Gene expression analysis; Id1; mRNA; PBMCs; Proliferation; Psoriasis

Although the precise causes of psoriasis are unclear, it is widely accepted that psoriasis is a disorder in which factors in the immune system, enzymes, and other biochemical substances that regulate skin cell division are impaired, leading to rapid proliferation of keratinocytes and incomplete keratinization. Expression of the helix-loop-helix transcription factor Id1 (inhibitor of ... more

C. Ronpirin; M. Achariyakul; T. Tencomnao; J. Wongpiyabovorn; W. Chaicumpa
10/17/2013
Esophageal cancer; Flow cytometry; Gene transfection; MT-1E; MT-3; Proliferation

Metallothionein (MT)-3 has cell growth inhibitory activity, and is the only currently known MT subtype with unique physiological functions. The expression levels of MT-1E, a subtype of MT-1, were positively correlated with the degree of esophageal cancer malignancy. The present study aimed to investigate the effects of MT-3 and MT-1E gene transfection on the proliferation, cell cycle, and ... more

Z.Q. Tian; Y.Z. Xu; Y.F. Zhang; G.F. Ma; M. He; G.Y. Wang
05/15/2012
NANOG; Neural differentiation; NT2/D1; OCT4; Proliferation; SOX2

SOX2, a universal marker of pluripotent stem cells, is a transcription factor that helps control embryonic development in vertebrates; its expression persists in neural stem/progenitor cells into adulthood. Considering the critical role of the SOX2 transcription factor in the regulation of genes required for self-renewal and pluripotency of stem cells, we developed and ... more

D. Drakulic; A. Krstic; M. Stevanovic
12/04/2014
Hypoxia; Osteogenesis; Osteogenic differentiation; Periodontal ligament stem cells; Proliferation

Changes in oxygen concentration may influence various innate characteristics of stem cells. The effects of varying oxygen concentration on human periodontal ligament stem cells (HPDLSCs) has not been explored, particularly under hypoxia-related conditions. First, HPDLSCs were cultured from the periodontium of human teeth using the outgrowth method. STRO-1 and CD146 expression of HPDLSCs ... more

Q.B. Zhang; Z.Q. Zhang; S.L. Fang; Y.R. Liu; G. Jiang; K.F. Li
04/14/2014
Anchor-independent growth; Colorectal cancer LoVo cell; ETS-1; LINE-1 ORF-1p; Proliferation; Transcriptional activation

The human proto-oncogene long interspersed nucleotide acid element-1 (LINE-1) open reading frame-1 protein (ORF-1p) is involved in the progress of several cancers. The transcription factor ETS-1 can mediate the transcription of some downstream genes that play specific roles in the regulation of cancerous cell invasion and metastasis. In this study, the effects of LINE-1 ORF-1p on ETS-1 ... more

M.Y. Li; M. Zhu; F. Feng; F.Y. Cai; K.C. Fan; H. Jiang; Z.Q. Wang; E.Q. Linghu
08/25/2014
Mesenchymal stem cell; Osteoblast differentiation; Proliferation; Rifampicin

This study was designed to investigate the effect of different concentrations of rifampicin on osteogenic differentiation and proliferation of mesenchymal stem cells (MSCs) in human bone marrow. Rifampicin treatment at 0, 4, 8, 16, 32, 64, and 128 mg/mL was applied throughout the whole process, from stromal cells purified from human bone marrow to differentiated bone cells. The effect of ... more

Z. Zhang; X. Wang; F. Luo; H. Yang; T. Hou; Q. Zhou; F. Dai; Q. He; J. Xu
06/26/2015
Differentiation; Erythropoietin; Mesenchymal stem cell; Proliferation; Signaling pathways

We examined whether erythropoietin (EPO) can inhibit adipogenic differentiation of mesenchymal stem cells (MSCs) in the mouse bone marrow and its underlying mechanism. We separated and extracted mouse bone marrow MSCs and induced adipogenic differen­tiation using 3-isobutyl-1-methylxanthine, insulin, and dexamethasone. Different concentrations of EPO were added to the cells and observed ... more

G.X. Liu; J.C. Zhu; X.Y. Chen; A.Z. Zhu; C.C. Liu; Q. Lai; S.T. Chen
01/13/2012
Breast cancer; Migration; NM23H1; Sodium valproate

Breast cancer is a common cancer in women, with a highly variable course, from inoffensive to lethal. To find a more effective strategy for its treatment, sodium valproate has been tested as an anti-cancer drug; it is the only clinically available histone deacetylase inhibitor. However, data about the effects of sodium valproate on breast cancer are insufficient in both animals and ... more

G.F. Li; T.L. Qian; G.S. Li; C.X. Yang; M. Qin; J. Huang; M. Sun; Y.Q. Han
09/12/2014
Effective population size; Microsatellite; Migration; Nong-Han Lake; Whisker sheatfish

Nong-Han Lake, Thailand, sustains the whisker sheatfish (Micronema bleekeri Günther, 1864), which is a rare species of freshwater catfish. Wild-caught whisker sheatfish has been intensively harvested to meet market demand; yet, genetic information about this species remains unknown. To assist with the in situ conservation of whisker sheatfish populations in Nong-Han Lake ... more

P. Phongkaew; U. Arunyawat; A. Swatdipong; V. Hongtrakul

Pages