Research Article

Related GMR Articles

Meta-analysis; Myocardial infarction; Polymorphism; TNF-β

Tumor necrosis factor-β (TNF-β) is an important mediator of inflammation and may play a role in the pathogenesis of myocardial infarction (MI). While several published studies have investigated the association between the C804A polymorphism in the TNF-β gene and MI risk, their results are controversial and ambiguous. In this study, we evaluated the contribution of the ... more

D.W. Suo; Q. Hu; J. Chen; Q.H. Sun; H. Guo
Alzheimer’s disease; Angiotensin-converting enzyme gene; Low-density lipoprotein receptor-related protein gene; Meta-analysis; Polymorphism; Presenilin 1 gene

The objective of this study was to assess the associations of presenilin 1 (PS1) 1/2, angiotensin I-converting enzyme (ACE) insertion/deletion (I/D), and low-density lipoprotein receptor-related protein (LRP) C/T polymorphisms with the risk of Alzheimer’s disease (AD) in the Chinese population. PS1 1/2, ACE I/D, and LRP C/T, which are commonly investigated polymorphisms, were evaluated to ... more

L. Yang; H.H. Zhou; Y.F. Ye; X.W. Fan; Y.J. Wang; Y. Meng
ADAM33; Asthma; Meta-analysis; Polymorphism

In this study, we evaluated the associations between the V4 (rs2787094 G>C) polymorphism in a disintegrin and metalloproteinase domain 33 (ADAM33) gene and asthma risk. We searched Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through August 2013, without language restrictions. Meta-analysis was performed using the STATA 12.0 ... more

W. Zheng; L. Wang; X. Su; X.F. Hu
Meta-analysis; Polymorphism; Primary biliary cirrhosis risk; VDR

The vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene encodes a protein that functions in the transcriptional regulation of vitamin D-responsive genes and plays a role in innate immunity and adaptive immune responses. In this study, we investigated the relationship between VDR polymorphisms (BsmI, ApaI, and TaqI) and primary biliary ... more

F. Fang; J. Wang; J. Pan; G.H. Su; L.X. Xu; G. Li
Insulin resistance; Meta-analysis; Obesity; Polymorphism; TNF-α

Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conf‍‍licting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE and EMBASE). No evidence of ... more

H.G. Wang; J. Yang; H. Han; F. Xu; Y. Bian; H. Zhang; J.L. Wang
Caspase; Gene polymorphisms; Lung cancer; Meta-analysis

The caspase (CASP) gene family is known to be involved in apoptosis, cytokine maturation, cell growth, and differentiation. A large number of single nucleotide polymorphisms (SNPs) in the CASP gene family have been increasingly recognized as important regulators in the development of lung cancer. However, this specific association is still controversial. In this Human Genome Epidemiology ... more

Z.Y. Zhang; Y. Xuan; X.Y. Jin; X. Tian; R. Wu
Lung cancer; Meta-analysis; T241M polymorphism; XRCC3

Numerous studies have evaluated the association between the X-ray repair cross-complementing group 3 (XRCC3) T241M polymorphism and lung cancer risk; however, the actual association is controversial. We examined whether the T241M polymorphism confers a lung cancer risk in China. We searched the PubMed, Google Scholar, and China National Knowledge Infrastructure databases to ... more

J.H. Zhang; Q.L. Wen; C. Yang; A.L. Li; Y. Liu; X.S. Li
Chemotherapy; Gene polymorphism; Lung cancer; Meta-analysis; Platinum; XRCC1

X-ray repair cross complementing group 1(XRCC1) polymorphisms have been implicated in interindividual variability of efficacy of platinum chemotherapy for treating non-small cell lung cancer (NSCLC); however, results of different studies have been inconsistent. We conducted a meta-analysis to investigate the association between polymorphisms in the XRCC1 gene and ... more

L. Li; C. Wan; F.Q. Wen
Genetic polymorphism; Lung cancer; Meta-analysis; rs401681 (G>A); TERT-CLPTM1L

A genome-wide association study revealed that a single nucleotide polymorphism, CLPTM1L - rs401681 (G>A), located at the 5p15.33 locus was significantly associated with increased risk of various cancers; however, its association with lung cancer is currently inconclusive. In order to explore the relationship between this polymorphism and lung cancer risk more precisely, we ... more

X.L. Zhang; X.J. Zhang; Y. Chen; Y.M. Zhang; Q. Zhang; C.X. Cao; D.Y. Gu; J.F. Shi; Y.L. Gong; J.F. Chen; C.J. Tang
Gene polymorphism; Interleukin-6; Lung cancer; Meta-analysis

The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphism and lung cancer by searching the ... more

Y. Liu; X.L. Song; G.L. Zhang; A.M. Peng; P.F. Fu; P. Li; M. Tan; X. Li; M. Li; C.H. Wang