Research Article

Related GMR Articles

Autoimmune diseases; IRF5; Meta-analysis

In this study, we investigated the association between 5 interferon regulatory factor-5 (IRF5) single nucleotide polymorphisms (SNPs) and autoimmune diseases using the Medline citation index. Twenty-eight studies with 74 comparisons, including 16 rheumatoid arthritis (RA), 43 systemic lupus erythematous (SLE), 2 juvenile idiopathic arthritis (JIA), 6 multiple sclerosis (MS), and 5 ... more

L. Tang; B. Chen; B. Ma; S. Nie
Bibliometric network; Glaucoma; LC cells; Meta-analysis; Target genes

Elevated intraocular pressure is recognized as the principal risk factor for development of optic nerve head (ONH) injury. Lamina cribrosa (LC) cells and astrocytes are two types of cells in the ONH. We attempted to identify more target genes and predict their underlying molecular mechanisms. In this study, we performed meta-analysis of the data from two microarray sets containing samples ... more

L.Y. Dong; M. Yin; X.L. Kang
Hepatocellular carcinoma; Meta-analysis; Single nucleotide polymorphism; XRCC1-Arg280His

Hepatocellular carcinoma (HCC) is one of the most life-threatening malignancies worldwide. Defects in DNA repair genes may increase the risk of HCC. X-ray cross-complementing group 1 gene (XRCC1) is a major DNA repair gene involved in base excision re­pair. Recently, several studies have indicated that an association exists between XRCC1 polymorphism and HCC, ... more

W. Xu; S. Liu; L. Li; Z.Y. Shen; Y.L. Wu
GSTP1; Hepatocellular carcinoma; Meta-analysis; Promoter methylation

Epigenetic silencing of the GSTP1 gene by promoter methylation has been associated with increased risk and shortened survival in patients with hepatocellular carcinoma (HCC). We therefore conducted a meta-analysis to obtain a more precise estimate of this association. By searching the Cochrane Library, CBM, EMBASE, PubMed, and the Web of Science, we tabulated and analyzed ... more

Q.F. Li; Q.Y. Li; A.R. Gao; Q.F. Shi
Cancer; Cytosolic serine hydroxymethyltransferase C1420T; Meta-analysis; Single nucleotide polymorphism

Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 23 published studies that included 14,409 cancer cases and 16,996 controls. A comprehensive search was ... more

T.T. Zhao; L.L. Shen; X.L. Zhang; D.Y. Gu; Q. Zhang; X.Y. Huo; C.J. Tang; J.F. Chen
Follicle-stimulating hormone receptor; Idiopathic infertility; Male infertility; Meta-analysis; Single nucleotide polymorphisms

Male infertility is a complex multifactorial and polygenic disease, and genetic factors play an important role in its formation and development. Recently, the association between follicle stimulating hormone receptor (FSHR) gene polymorphisms and male infertility risk has attracted widespread attention due to the unique biological functions of FSH. The aim of this study was to ... more

X.Q. Wu; S.M. Xu; Y.Q. Wang; Q. Li; Z.Q. Wang; C.L. Zhang; Y. Shen
Bladder cancer; CYFRA21-1; Meta-analysis

The proteolytic region of cytokeratin-19, referred to as CYFRA21-1, is a soluble molecule present in the serum and other body fluids, and is considered a tumor marker in several neoplastic diseases. To examine whether urinary or serum samples containing CYFRA21-1 can be used as biomarkers for bladder cancer, we conducted a comprehensive meta-analysis of 3 case-control studies. In all ... more

L.I. Kuang; W.J. Song; H.M. Qing; S. Yan; F.L. Song
Cancer; DNA (cytosine-5)-methyltransferase 3A; Meta-analysis; Single nucleotide polymorphism

Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies ... more

C.H. Liu; T. Tao; L. Jiang; B. Xu; L. Zhang; K. Lu; X.W. Zhang; S.Q. Chen; D.C. Liu; M. Chen
Genetic polymorphism; Meta-analysis; Overactive bladder risk; β3-adrenoceptor genes

Genetic variations in the human β3-adrenoceptor (β3-AR) gene are known to be involved in insufficient relaxation of the bladder muscle during urine storage. The Trp64Arg polymorphism in the β3-AR gene has been found to be an important regulator of the development of overactive bladder (OAB). However, the association between this polymorphism and OAB remains controversial. Therefore, we ... more

H.C. Qu; W. Zhang; Y.L. Liu; P. Wang
Ischemic stroke; Meta-analysis; β-fibrinogen

To clarify the relationship between the β-fibrinogen (FGB) genetic polymorphism (-148C>T) and ischemic stroke, we identified studies by searching PubMed, EMBASE, and the Chinese National Knowledge Infrastructure (CKNI) databases. Data from eligible studies were extracted and subjected to meta-analysis. Publication bias was tested using a funnel plot. We identified 12 ... more

X.F. Zhang; T.Y. Luo