Research Article

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11/12/2012
Gastric cancer; Meta-analysis; Polymorphism; susceptibility; XRCC1

Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a ... more

B.M. Liu; T.M. Liu; B.S. You; H.Y. You; J. Yang; L. Li; Y.C. He
09/26/2012
Bladder cancer; Genetic susceptibility; hOGG1; Meta-analysis; Polymorphism

The functional polymorphism Ser326Cys (rs1052133) in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in bladder cancer risk. However, reports of this association between the Ser326Cys polymorphism and bladder cancer risk are conflicting. In order to help clarify this relationship, we made a meta-analysis of seven case-control studies, summing 2521 cases ... more

D.Y. Zhong; H.Y. Chu; M.L. Wang; L. Ma; D.N. Shi; Z.D. Zhang
09/25/2012
Colorectal cancer; Interleukin-10; Meta-analysis; Polymorphism

In order to make a comprehensive assessment of the potential association between two genetic variants in the IL-10 gene promoter, -1082 A>G (rs1800896) and -592 C>A (rs1800872), and colorectal cancer (CRC) risk, we conduced a meta-analysis of seven epidemiological studies, which included 1469 colorectal cancer cases and 2566 controls. Neither of the two polymorphisms had any ... more

Y.M. Zhang; X.C. Zhou; Z. Xu; C.J. Tang
08/13/2012
Gastric cancer; Meta-analysis; NQO1 gene; Polymorphism; Risk

The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95% confidence interval (95 ... more

Y. Zhang; Z.T. Wang; J. Zhong
12/04/2014
Alzheimer’s disease; Meta-analysis; MicroRNA; Oxidized low density lipoprotein receptor 1; Polymorphism

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that contributes to dementia in the elderly population. Genome-wide linkage analysis has identified chromosome 12p as the AD-susceptible region, which includes lectin-like oxidized low-density lipoprotein receptor 1 (OLR1). The OLR1 +1073 C/T single-nucleotide polymorphism is located in the 3'- ... more

Y. Kong; J.B. Wu; X. Wang; J.F. Zhao; H. Song; L.D. Yuan
12/04/2014
Meta-analysis; Microsomal transfer protein; Non-alcoholic fatty liver disease; Polymorphism

Several studies have found that microsomal transfer protein (MTP) may be important in the development and progression of non-alcoholic fatty liver disease (NAFLD). In this meta-analysis, we evaluated the relationships between a common polymorphism (-493G>T, rs1800591 G>T) in the MTP gene and NAFLD risk. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, ... more

L. Li; S.J. Wang; K. Shi; D. Chen; H. Jia; J. Zhu
10/20/2014
Atrial fibrillation; KCNE1; Meta-analysis; Polymorphism; susceptibility

KCNE1, a membrane protein that spans the membrane once is responsible for modulating potassium channel functions and plays an important role in the etiology of arrhythmia. Emerging evidence indicates that a common polymorphism (112G>A; rs1805127 G>A) in the KCNE1 gene contributes to atrial fibrillation (AF) risk; however, these studies showed inconclusive results. In this ... more

H.G. Han; H.S. Wang; Z. Yin; H. Jiang; M. Fang; J. Han
10/07/2014
Angiotensin-converting enzyme; Association; Meta-analysis; Polymorphism; Systemic sclerosis

The purpose of this study was to examine whether the insertion (I) or deletion (D) polymorphism of the angiotensin-converting enzyme gene (ACE) is associated with susceptibility to systemic sclerosis (SSc). A meta-analysis examining the associations between the ACE I/D polymorphism and SSc was conducted in overall and European populations using 1) allelic contrast (D ... more

G.G. Song; Y.H. Lee
10/07/2014
EGF; Liver cancer; Meta-analysis; Meta-regression; Polymorphism

Emerging evidence suggests that a common functional polymorphism, rs4444903 (A>G), in the EGF gene might impact an individual’s susceptibility to liver cancer; however, individually published results are inconclusive. This meta-analysis aimed to derive a more precise estimation of the relationship between the EGF rs4444903 polymorphism and liver cancer risk. A ... more

Y.L. Li; Z. Tian; L. Zhao; C.L. Zhang
08/25/2014
ADAM33; COPD; Meta-analysis; Polymorphism

Numerous studies have evaluated the association between polymorphisms of a disintegrin and metalloproteinase 33 (ADAM33) gene and chronic obstructive pulmonary disease (COPD) risk; however, the results remain conflicting. The aim of this study was to investigate whether ADAM33S2 and -T1 polymorphisms are associated with susceptibility to COPD risk in the Chinese population. Publications ... more

D.D. Li; S.J. Guo; L.Q. Jia; F.Q. Wen

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