Research Article

Related GMR Articles

10/15/2013
EPHX1 gene; Esophageal cancer; Meta-analysis; Polymorphism

Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the results have been contradictory. We investigated the association of EPHX1 Tyr113His and ... more

J.J. Hu; Z.T. Wang; B. Li
09/12/2014
Breast cancer; EPHX1; Lung cancer; Meta-analysis; Polymorphism

The association between the microsomal epoxide hydrolase 1 gene (EPHX1) Tyr113His polymorphism and lung cancer and breast cancer risk has been reported in many recent studies, but there is no consensus among the results. Thus, we examined the association between the EPHX1 Tyr113His polymorphism and lung cancer through a meta-analysis. A comprehensive literature search was ... more

X. Tan; Y.Y. Wang; X.Y. Chen; L. Xian; J.J. Guo; G.B. Liang; M.W. Chen
01/28/2014
EPHX1; Esophageal cancer; Meta-analysis; Polymorphism

Microsomal epoxide hydrolase 1 (EPHX1) is an important biological phase II metabolic enzyme that is extensively involved in the metabolism of diverse environmental carcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Many articles have reported the association between EPHX1 (Tyr113His and His139Arg) polymorphisms and esophageal cancer risk, but the results are ... more

X. Tan; W.W. He; Y.Y. Wang; L.J. Shi; M.W. Chen
02/13/2015
GSTM1; Lung cancer; Meta-analysis; Polymorphism

The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform literature ... more

H. Liu; H.F. Ma; Y.K. Chen
04/26/2013
CCND1 gene; Esophageal cancer; Genetic association; Meta-analysis; Polymorphism

The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the allelic/genotypic ... more

W. Cai; Z.T. Wang; J. Zhong; Y. Zhang
06/12/2015
Esophageal cancer; Meta-analysis; miR-21; Prognosis

The present study aimed to explore the relationship between miRNA expression and survival in patients with esophageal cancer (EC) using meta-analysis. We searched PubMed, EMBASE, CNKI, Wanfang, and ISI Web of Science databases without time restrictions, and extracted relevant data, such as the name of first author, publication year, age, gender, number of case, etc. from the studies ... more

S.W. Wen; Y.F. Zhang; Y. Li; Z.X. Liu; H.L. Lv; Z.H. Li; Y.Z. Xu; Y.G. Zhu; Z.Q. Tian
12/08/2011
Colorectal cancer; Meta-analysis; Polymorphism; VEGF

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains controversial. We made a meta-analysis of the association ... more

L.P. Zhou; H. Luan; X.H. Dong; G.J. Jin; D.L. Man; H. Shang
12/08/2011
Endometrial cancer; Meta-analysis; p53 gene; Polymorphism; susceptibility

Polymorphisms of the p53 gene have been associated with susceptibility to endometrial cancer. However, whether there is a specific association is still controversial. We investigated a possible association between p53 codon 72 polymorphism and endometrial cancer risk by conducting a meta-analysis. Publications addressing this association were selected from the Pubmed, Embase and CBM ... more

Y. Gu; X. Zhou; S.L. Zhang
12/08/2011
Head and neck cancer; Meta-analysis; Polymorphism; XPD

Several studies have investigated the association between Lys751Gln polymorphism in the xeroderma pigmentosum group D (XPD) gene and risk of head and neck cancer; however, the published results are conflicting. We conducted a meta-analysis that comprised 15 published case-control studies examining the association of head and neck cancer risk with XPD Lys751Gln ... more

H. Yuan; Y.M. Niu; R.X. Wang; H.Z. Li; N. Chen
12/15/2011
Human leukocyte antigen; Meta-analysis; Polymorphism; Psoriasis; Risk

Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a meta-analysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 psoriasis patients and 3297 healthy controls. The associations ... more

D. Wu; Y. Wu; J.L. Liu; B. Wang; X.D. Zhang

Pages