Research Article

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Colostrum; Goat; Mature milk; MicroRNA

Immune-related miRNAs in breast milk are extracellular miRNAs that are related to immune organ development and regulation of the immune function in infants and young animals. The goal of this study was to compare the expression levels of five immune-related miRNAs in breast milk in black goats, humans, and dairy cattle. The miRNAs from milk were extracted and the expression levels were ... more

R.S. Na; G.X. E; W. Sun; X.W. Sun; X.Y. Qiu; L.P. Chen; Y.F. Huang
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ABO blood group; ABO gene; Brazilian population; DNA polymorphism; Genetic polymorphism; Leukemia

The ABO blood group is the most important blood group system in transfusion medicine and organ transplantation. To date, more than 160 ABO alleles have been identified by molecular investigation. Almost all ABO genotyping studies have been performed in blood donors and families and for investigation of ABO subgroups detected serologically. The aim of the ... more

M.C.Z. Novaretti; A.E. Domingues; R. Manhani; E.M. Pinto; P.E. Dorlhiac-Llacer; D.A.F. Chamone
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Bioinformatics; Differentially expressed genes; Leukemia

The purpose of this study was to identify differentially expressed genes and analyze biological processes related to leukemia. A meta-analysis was performed using the Rank Product package of Gene Expression Omnibus datasets for leukemia. Next, Gene Ontology-enrichment analysis and pathway analysis were performed using the Gene Ontology website and Kyoto Encyclopedia of Genes and Genomes ... more

Z.Y. Zhang; R.Q. Xu; T.J. Guo; M. Zhang; D.X. Li; X.Y. Lu
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Dendritic cell; IL-10; IL-12; Leukemia; Tartary buckwheat lectin

The present study aims to purify and characterize lectin from tartary buckwheat seeds and study its properties as well as biological activities to determine its possible biomedical applications in promoting maturation and proliferation of peripheral blood DCs derived from healthy donors and to study the effect of inducing apoptosis in human leukemia U937 cells. A novel tartary buckwheat ... more

C.Z. Bai; H.J. Ji; M.L. Feng; X.L. Hao; Q.M. Zhong; X.D. Cui; Z.H. Wang
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MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression by translational repression or transcript degradation. A large number of miRNAs have been identified from model plant species; however, the character of conserved miRNAs is poorly understood. We studied 42 miRNA families that are conserved within the plant kingdom, using the miRBase database. Some conserved miRNA ... more

Z.J. Yin; F.F. Shen
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miR-212; miRNAs; Overexpression; Target genes

MicroRNAs (miRNAs) are a type of non-protein-coding single-stranded RNA, which are typically 20-25 nt in length. miRNAs play important roles in various biological processes, including development, cell proliferation, differentiation, and apoptosis. We aimed to detect the miRNA response to cocaine stimulations and their target genes. Using the miRNA expression data GSE21901 downloaded from ... more

L.F. Xu; J. Wang; F.B. Lv; Q. Song
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Computational prediction; Glycine max; MicroRNAs; Nodulation; Target genes

MicroRNAs (miRNAs) are small molecules, noncoding proteins that are involved in many biological processes, especially in plants; among these processes is nodulation in the legume. Biological nitrogen fixation is a key process, with critical importance to the soybean crop. This study aimed to identify the potential of novel miRNAs to act during the root nodulation process. We utilized a ... more

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Bibliometric network; Glaucoma; LC cells; Meta-analysis; Target genes

Elevated intraocular pressure is recognized as the principal risk factor for development of optic nerve head (ONH) injury. Lamina cribrosa (LC) cells and astrocytes are two types of cells in the ONH. We attempted to identify more target genes and predict their underlying molecular mechanisms. In this study, we performed meta-analysis of the data from two microarray sets containing samples ... more

L.Y. Dong; M. Yin; X.L. Kang
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Computational identification; MicroRNAs; Phaseolus vulgaris; Target genes

MicroRNAs (miRNAs) are a class of non-coding small RNAs that negatively regulate gene expression at the post-transcriptional level. Although thousands of miRNAs have been identified in plants, limited information is available about miRNAs in Phaseolus vulgaris, despite it being an important food legume worldwide. The high conservation of plant miRNAs enables the identification of ... more

J. Han; H. Xie; M.L. Kong; Q.P. Sun; R.Z. Li; J.B. Pan
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Differentially expressed genes; Epstein-Barr virus-positive nasopharyngeal carcinoma; Target genes; Typical miRNAs

This study aims to identify the crucial miRNAs in Epstein-Barr virus-positive nasopharyngeal carcinoma (NPC) and their target genes. Gene expression profile data (GSE12452) that included 31 NPC and 10 normal nasopharyngeal tissue specimens were downloaded. Differentially expressed genes (DEGs) were identified using significance analysis of microarrays. The underlying function of DEGs was ... more

L.H. Zhu; X.T. Miao; N.Y. Wang

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