Research Article

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05/15/2012
Cross-combination; Cyprinus carpio; DNA sequence; IGF2a; SNP

We studied whether two IGF2 transcripts in common carp are similar to those found in zebrafish. The full-length IGF2a cDNA contains a 5'-terminal untranslated region (UTR) of 105 bp, a 3'-terminal UTR of 1358 bp and an open reading frame of 612 bp, which encodes a 206-amino acid protein. A 6614-bp full-length IGF2a DNA molecule, including the 5'-flanking region ... more

S.Y. Su; Z.J. Dong; J.Q. Qu; Z.Y. Liang; J.Q. Zhang; L.X. Ma; W. Liu; P. Xu; X.H. Yuan
04/03/2012
meat quality; Mutation; Ryanodine receptor protein; SNP

Some genes affect meat quality in chickens. We looked for polymorphisms in the Gallus gallus α-RyR gene (homologous to RyR 1) that could be associated with PSE (pale, soft and exudative) meat. Because RyR genes are over 100,000 bp long and code for proteins with about 5000 amino acids, primers were designed to amplify a fragment of hotspot region 2, a region with a high density ... more

A.A. Droval; E. Binneck; S.R.R. Marin; F.G. Paião; A. Oba; A.L. Nepomuceno; M. Shimokomaki
03/16/2012
ATP1A1; Dairy cow; K+-ATPase; Mastitis; Na+; SNP; Somatic cell score

Mastitis affects the concentrations of potassium and sodium in milk. Since sodium-potassium adenosine triphosphatase (Na+, K+-ATPase) is critical for maintaining the homeostasis of these two ions, and is involved in cell apoptosis and pathogenesis, we presumed that polymorphism of the ATP1A1 gene, which encodes the bovine Na+, K+-ATPase ... more

Y.X. Liu; C.H. Xu; T.Y. Gao; Y. Sun
03/22/2012
BDNF; DARPP; Restriction fragment length polymorphism; Schizophrenia; SNP

A number of studies have pointed to the association of BDNF (brain-derived neurotrophic factor) and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) with schizophrenia. The purpose of this study was to determine whether these two genes are involved in the pathogenesis of schizophrenia in the Malay population. Two single nucleotide polymorphisms Val66Met of ... more

H.C. Loh; P.Y. Tang; S.F. Tee; T.J. Chow; Y.C. Cheah; S.S.J. Singh
01/31/2012
BMD; Genome-wide association studies; Osteoporotic fractures; SNP

Osteoporosis is a heritable disease characterized mainly by low bone mineral density (BMD) and/or osteoporotic fractures (OF). Most genome-wide association studies on osteoporosis have focused on BMD, whereas little effort has been expended to identify genetic variants directly linked to OF. To determine whether BMD-loci are also associated with OF risk, we performed a validation study to ... more

Y. Guo; J.T. Wang; H. Liu; M. Li; T.L. Yang; X.W. Zhang; Y.Z. Liu; Q. Tian; H.W. Deng
02/16/2012
CLPTM1L; Lung adenocarcinoma; Lung cancer; SNP; TERT

Recent studies have shown that 5p15.33 is one of the chromosomal regions that is most consistently altered in lung cancer; common variants that are located in this region have been genotyped in various populations. However, the genetic contribution of these variants to carcinogenesis is relatively unknown. A clinic-based case-control study in Shanghai was undertaken on 196 patients with ... more

X.F. Chen; S. Cai; Q.G. Chen; Z.H. Ni; J.H. Tang; D.W. Xu; X.B. Wang
08/07/2014
Gestational hypertension; LIPC gene; Lipid metabolism; Preeclampsia; SNP

We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. Clinically defined HDCP patients (N = 321) and healthy pregnant women (N = 331) were recruited and genotyped using polymerase chain reaction- ... more

H. Lin; Z. Yin; X.Y. Yu; N. Lin; Y. Lin; J. Chen; Y.Z. Chen; K.P. Lu; H.K. Liu
03/12/2014
Dopamine; DRD5; Haplotype; Paranoid schizophrenia; SNP

Dopamine (DA) has been implicated in the pathophysiol­ogy of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopa­mine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs) in the regulatory regions of DRD5 gene may affect ... more

Y. Zhao; M. Ding; H. Pang; X.M. Xu; B.J. Wang
03/12/2014
5-HT; Haplotype; Paranoid schizophrenia; Serotonin; SNP; TPH2

In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nucleotide polymorphisms (SNPs) in the regulatory regions of TPH2 ... more

X.M. Xu; M. Ding; H. Pang; B.J. Wang
01/14/2014
Association analysis; Pig; Reproductive trait; RFRP gene; SNP

RFamide-related peptide (RFRP) gene is a crucial gene of the hypothalamo-pituitary-gonadal axis and plays an important role in reproduction regulation. This study aimed to clone and characterize the pig RFRP gene. We obtained a 645-bp cDNA of pig RFRP gene comprising a 546-bp open reading frame, which encoded a peptide of 188 amino acids. The pig RFRP coding ... more

M.X. Fang; Y.S. Huang; J. Ye; W. Zhang; Y. Li; Q.H. Nie

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