Research Article

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Hepatocellular carcinoma; Molecular marker; Single nucleotide polymorphism; susceptibility; XRCC1 gene

The human X-ray repair cross-complementing protein 1 (XRCC1) gene is a potentially gene determining hepatocellular carcinoma (HCC) susceptibility. The purpose of this study was to evaluate the association between XRCC1 and susceptibility to HCC. The association of XRCC1 polymorphisms with HCC susceptibility was investigated in 460 HCC patients and 463 controls ... more

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Neovascular age-related macular degeneration; Polypoidal choroidal vasculopathy; Single nucleotide polymorphism; TLR3

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FGD1; Intellectual developmental disorders; Restriction fragment length polymorphism; Single nucleotide polymorphism; Single-strand conformation polymorphism

FGD1 encoding a guanine nucleotide exchange factor, specifically activates Rho GTPase cell division cycle 42 (Cdc42). Dysfunction of FGD1 causes Aarskog-Scott syndrome (MIM #305400), an X-linked disorder that may affect bone and intellectual development. However, the relationship between FGD1 and intellectual developmental disorders (IDD) remains unclear. The purpose of this study was to ... more

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Hepatocellular carcinoma (HCC) is one of the most life-threatening malignancies worldwide. Defects in DNA repair genes may increase the risk of HCC. X-ray cross-complementing group 1 gene (XRCC1) is a major DNA repair gene involved in base excision re­pair. Recently, several studies have indicated that an association exists between XRCC1 polymorphism and HCC, ... more

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Growth trait; IAG gene; Oriental river prawn; Single nucleotide polymorphism

Increasing evidence suggests that the insulin-like andro­genic gland hormone (IAG) gene plays an important role in male sexual differentiation, metabolism, and growth in crustaceans. In the present study, we isolated the full-length genome sequence of IAG by genome walking based on the cDNA sequence in Macrobrachium nipponense. Four novel single nucleotide ... more

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Cyclin D1; Multiple myeloma; Single nucleotide polymorphism

Cyclin D1 is an important cell cycle regulator implicated in the pathogenesis of many cancer types. In particular, translocation and overexpression of cyclin D1 are common events in multiple myeloma (MM), suggesting that it may drive the initiation and progression of this malignancy. However, the association between genetic polymorphisms of cyclin D1 and the risk for developing MM remains ... more

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Korean native pig; MHC class I; Single nucleotide polymorphism; SLA-3

We investigated the phylogenetic relationships between pig breeds, compared the genetic similarity between humans and pigs, and provided basic genetic information on Korean native pigs (KNPs), using genetic variants of the swine leukocyte antigen 3 (SLA-3) gene. Primers were based on sequences from GenBank (accession Nos. AF464010 and AF464009). Polymerase chain reaction analysis ... more

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Average daily gain; Beef cattle; Feed efficiency; Genome-wide association study; Nellore; Single nucleotide polymorphism

Weight gain is a key performance trait for beef cat­tle; however, attention should be given to the production costs for better profitability. Therefore, a feed efficiency trait based on per­formance can be an interesting approach to improve performance without increasing food costs. To identify candidate genes and ge­nomic regions associated with residual body weight gain (RWG), we ... more

M.H.A. Santana; R.C. Gomes; Y.T. Utsunomiya; H.H.R. Neves; F.J. Novais; M.N. Bonin; H. Fukumasu; J.F. Garcia; P.A. Alexandre; G.A.Oliveira Junior; L.L. Coutinho; J.B.S. Ferraz

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