Research Article

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10/27/2014
Body measurement; Genetic variability; meat quality; Single nucleotide polymorphism; SIRT2

Silent information regulator 2 (SIRT2), a member of the Sirtuin family of class III nicotinamide adenine dinucleotide-dependent protein deacetylases, plays an important role in senescence, metabolism, and apoptosis. This study was conducted to detect potential polymorphisms of the bovine SIRT2 gene and explore their relationships with meat quality and body measurement traits ( ... more

L.S. Gui; W.C. Yang; C.P. Zhao; S.J. Wei; Z.D. Zhao; L.S. Zan
10/31/2014
Chemotherapy; Excision repair cross-complementation group 1; Non-small cell lung cancer; Single nucleotide polymorphism; Survival time

We conducted a cohort study to investigate the role of 3 single-nucleotide polymorphisms of the excision repair cross-complementation group 1 (ERCC1) gene on the response to chemotherapy and clinical outcomes of non-small cell lung cancer (NSCLC). A total of 163 patients with newly diagnosed and histopathologically confirmed primary NSCLC were examined in our study and were ... more

H. Gao; R.C. Ge; H.Y. Liu; Y. Wang; S. Yan
10/20/2014
Capra hircus; Cytokine; Gastrointestinal infection; Single nucleotide polymorphism

Cytokines are small cell-signaling proteins that play an important role in the immune system, participating in intracellular communication. Four candidate genes of the cytokine family (IL2, IL4, IL13, and IFNG) were selected to identify Single Nucleotide Polymorphisms (SNPs) that might be associated with resistance to gastrointestinal endoparasites in ... more

F.A. Bressani; P.C. Tizioto; R. Giglioti; S.L.C. Meirelles; R. Coutinho; C.L. Benvenuti; W. Malagó-Jr.; M.A. Mudadu; L.S. Vieira; L.G. Zaros; E. Carrilho; L.C.A. Regitano
04/03/2014
Case-control study; DKK1; Single nucleotide polymorphism; Tooth agenesis

Tooth agenesis is one of the most common anomalies of human dentition. Recent genetic studies have provided information regarding a number of genes related to both syndromic and non-syndromic forms of hypodontia. In a previous study, we found that polymorphism in rs11001553 of DKK1 was associated with hypodontia in the Chinese Han population. In this study, we extended this ... more

H.C. Liu; J. Zhang; S. Wong; D. Han; H.S. Zhao; H.L. Feng
08/25/2014
Blanco Orejinegro; Genome-wide association study; Growth traits; Romosinuano; Single nucleotide polymorphism

Whole genome selection represents an important tool for improving parameters related to the production of livestock. In order to build genomic selection indexes within a particular breed, it is important to identify polymorphisms that have the most significant association with a desired trait. A genome-wide marker association approach based on the Illumina BovineSNP50 BeadChipTM ... more

R. Martínez; Y. Gómez; J.F.M. Rocha
08/07/2014
Gastric cancer; Interleukin-1b; Single nucleotide polymorphism

The aim of this study was to examine the interleukin-1B (IL-1B) gene promoter region -31 (IL-1B-31) polymorphism distribution characteristic of Hakka gastric cancer patients in Guangdong Province and to explore its association with gastric cancer. We used the 1:1 case-control method, matrix-assisted laser desorption ionization flight time mass spectrometry, and MassARRAY-IPLEX technology ... more

B. Qiu; H.Y. Zou; Y.H. Yang; C.F. Lai
07/04/2014
Insulin-induced gene 2; Obesity; Single nucleotide polymorphism

A genome-wide association study showed that the tagging single nucleotide polymorphism (SNP) rs7566605 in the insulin-induced gene 2 (INSIG2) was associated with obesity. Attempts to replicate this result in different populations have produced inconsistent findings. We aimed to study the association between the rs7566605 SNP with obesity and other metabolic parameters in ... more

Y.D. Apalasamy; F.M. Moy; S. Rampal; A. Bulgiba; Z. Mohamed
05/16/2014
Association study; BRCA2; Cardiovascular disease; HapMap; Saudi Arabian population; Single nucleotide polymorphism

Abnormalities in the breast cancer tumor suppressor genes (BRCA1 and BRCA2) are associated with breast and ovarian cancer. Recently, two single nucleotide polymorphisms (SNPs; rs11571836 and rs1799943) were identified, both located in untranslated regions of chromosome 13, associated with cardiovascular disease (CVD) in a multi-ethnic population. We examined the ... more

M. Alanazi; N.P. Reddy; J.P. Shaik; S.A. Ajaj; A.A.A. Jafari; H. Saeed; Z. Khan; A.P. Khan
05/09/2014
Colorectal cancer; Gastric cancer; Single nucleotide polymorphism; susceptibility

Evidence suggests that some genetic variants are risk factors for both colorectal cancer (CRC) and gastric cancer (GC). Thus, we selected 12 reported single nucleotide polymorphisms (SNPs) from genome-wide association studies of CRC and conducted this case-control study to assess the associations between these SNPs and the risk for GC in a southern Chinese population. All SNPs were ... more

C.P. Zhou; H.Z. Pan; F.X. Li; N.Y. Hu; M. Li; X.X. Yang
02/27/2014
Apolipoprotein E; Chinese Hui population; Essential hypertension; Single nucleotide polymorphism

In the present study, the correlation of polymorphisms of the apolipoprotein E (apoE) gene with the susceptibility of essential hypertension (EH) was investigated. Single nucleotide polymorphisms of the apoE gene at the -491 A>T, +969 C>G, and +2836 G>A sites were determined in 221 non-EH individuals and 109 subjects with EH of Chinese Hui ethnicity using ... more

Y. Yang; J.R. Xu; X.M. Liu; J. Zhou; B. Yang; M. Li; Y.J. Wang

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