Research Article

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12/08/2011
Breast cancer; CYP2C19; Genetics; Polymorphism

Cytochrome P450 (CYP) 2C19 metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids, which significantly promote proliferation of cancer cells in vitro and in vivo. We looked for a possible association between human CYP2C19*3 gene polymorphism and breast cancer in the Chinese Han population. In a Chinese Han case-control study of breast cancer ... more

C.Q. Gan; X.Y. Wang; Y.D. Cao; W.X. Ye; H. Liu; Y.Y. Sun
12/08/2011
FMF; Haplotype; MDR1; Polymorphism; Turkey

The multidrug resistance (MDR1) gene encodes a P-glycoprotein that plays a key role in drug bioavailability and response to drugs in different human populations. More than 50 SNPs have been described for the MDR1 gene. Familial Mediterranean fever (FMF) is considered an autosomal recessive hereditary disease, associated with a single gene named the Mediterranean fever gene (MEFV). However ... more

A. Rüstemoglu; G. Gümüş-Akay; S. Yigit; T. Tasliyurt
12/08/2011
Alternative splicing variant; DRD2 gene; Expression; Pig; Polymorphism

The dopamine D2 receptor (DRD2) is a crucial mediator for normal physiological processes. We cloned the pig DRD2 gene, investigated its distribution in tissues and identified polymorphisms by RT-PCR, quantitative real-time PCR and direct sequencing. Two Yorkshire pigs from Guangdong Academy of Agricultural Sciences (Guangzhou, China) were selected to clone the gene and ... more

H.P. Xu; X.M. He; M.X. Fang; Y.S. Hu; X.Z. Jia; Q.H. Nie; X.Q. Zhang
12/08/2011
Head and neck cancer; Meta-analysis; Polymorphism; XPD

Several studies have investigated the association between Lys751Gln polymorphism in the xeroderma pigmentosum group D (XPD) gene and risk of head and neck cancer; however, the published results are conflicting. We conducted a meta-analysis that comprised 15 published case-control studies examining the association of head and neck cancer risk with XPD Lys751Gln ... more

H. Yuan; Y.M. Niu; R.X. Wang; H.Z. Li; N. Chen
11/17/2011
Malaysia; Polymorphism; RANTES; SDF; SLE

Regulated on activation, normal T-cell expressed and secreted (RANTES) and stromal cell-derived factor 1 (SDF-1) are members of the CC- and CXC-chemokine families, respectively. Both genes have been postulated to be involved in the pathogenesis of systemic lupus erythematosus (SLE). We analyzed position 28 of the RANTES gene promoter region, as well as the SNP observed in the 3' ... more

L.H. Lian; B.P. Kee; H.L. Ng; K.H. Chua
11/04/2011
AGPAT6 gene; Dairy goat; Milk traits; PCR-RFLP; Polymorphism

As one of the eight members in the 1-acylglycerol-3-phosphate-O-acyltransferase (AGPATs) family, AGPAT6 is a crucial enzyme for the biosynthesis of glycerolipids and triacylglycerol in eukaryotes, as well as catalyzing the conversion from lysophosphatidic acid to phosphatidic acid. AGPAT6 can be considered as a candidate gene for regulating milk composition. DNA ... more

C. He; C. Wang; Z.H. Chang; B.L. Guo; R. Li; X.P. Yue; X.Y. Lan; H. Chen; C.Z. Lei
10/13/2011
Lung cancer risk; Meta-analysis; p21; Polymorphism; Ser31Arg

The cyclin-dependent kinase inhibitor 1A (also known as p21) is thought to be involved in tumor development by mediating cell cycle arrest through the inhibition of cyclin/CDK activity. To explore the relationship of Ser31Arg polymorphism in the p21 gene with the risk of developing lung cancer, we performed an overall and stratified meta-analysis based on ethnicity, lung ... more

G. Lin; F. Fang; X.J. Yu; L. Yu
09/12/2011
Genetic marker; Larus saundersi; Microsatellite; Polymorphism; Saunders’s gull

Nine polymorphic microsatellite loci were isolated, using tetranucleotide repeat oligonucleotide probes from an enriched DNA library of the globally “vulnerable” Saunders’s gull (Larus saundersi), collected from the Yancheng coastal wetland, one of the three remaining breeding sites in China. Six breast muscle tissues and 16 blood samples from 22 gulls and eight eggshell membrane ... more

H.X. Jiang; S.L. Ren; Y.Q. Hou; M. Yang; X.B. Wu
09/09/2011
BMD; CYP17; CYP19; Estradiol; Osteoporosis; Polymorphism

Many clinical conditions, including osteoporosis, are associated with serum levels of sex steroids. Enzymes that regulate rate-limiting steps of steroidogenic pathways, such as CYP17 and CYP19, are also regarded as significant factors that may cause the development of these conditions. We investigated the association of two common polymorphisms, in the promoter region (T→C substitution) ... more

M.B. Yilmaz; A. Pazarbasi; A.I. Guzel; S. Kocaturk-Sel; H. Kasap; M. Kasap; I.F. Urunsak; S. Basaran; D. Alptekin; O. Demirhan
08/30/2011
Aggrecan gene; Disc degeneration; Lumbar; Polymorphism

We investigated a possible association between aggrecan gene polymorphism and lumbar degenerative disc disease in Turkish patients. One hundred 20-30-year-old patients with or without low back pain were selected for the study. Lumbar magnetic resonance imaging was performed on all patients. The patient group had low back pain clinically and degenerative disc disease ... more

O. Eser; B. Eser; M. Cosar; M.O. Erdogan; A. Aslan; H. Yıldız; M. Solak; A. Haktanır

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