Research Article

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Association analysis; Bone mineral density; Osteoporosis; Osteoprotegerin gene; Postmenopausal women; Single nucleotide polymorphisms

Osteoporosis is an important and common complex health problem, particularly in postmenopausal women. It is characterized by a reduction in bone mineral density (BMD) and a deterioration of bone microarchitecture with a consequent increase of fracture risk. The osteoprotegerin (OPG) gene is considered to play an important role in the pathogenesis of osteoporosis. We analyzed SNPs ... more

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Bone mineral density; Genetic variants; Osteoporosis; Osteoprotegerin gene

The purpose of this study was to investigate the association of the g.27667T>A genetic variant in the osteoprotegerin (OPG) gene with bone mineral density (BMD) and osteoporosis. A total of 393 primary osteoporosis subjects and 402 healthy controls were recruited. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were evaluated by Norland XR-46 dual-energy ... more

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Bone mineral density; Genetic variant; Osteoprotegerin gene; Primary osteoporosis; Risk factor

Primary osteoporosis is a common health problem in postmenopausal women. This study aimed to detect the association of the g.19074G>A genetic variant in the osteoprotegerin gene (OPG) with bone mineral density (BMD) and primary osteoporosis. The created restriction site-polymerase chain reaction method was used to investigate the g.19074G>A genetic variant. The BMD of the ... more

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Bone mineral density; Osteoporosis; Postmenopausal women; VDR polymorphisms

We investigated associations between vitamin D receptor (VDR) gene polymorphisms, FokI T>C (rs2228570), BsmI G>A (rs1544410), ApaI G>T (rs7975232), and TaqI T>C (rs731236), with bone mineral density (BMD) in postmenopausal Mexican-Mestizo women. Three hundred and twenty postmenopausal women participated, who were classified ... more

A. González-Mercado; J.Y. Sánchez-López; J.A. Regla-Nava; J.I. Gámez-Nava; L. González-López; J. Duran-Gonzalez; A. Celis; F.J. Perea-Díaz; M. Salazar-Páramo; B. Ibarra
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aldosterone; cortisol; Genetic polymorphism; MDR1; menstrual cycle; P-glycoprotein

ABCB1, also known as MDR1/P-glycoprotein, can transport cortisol and aldosterone. We examined the effects of ABCB1 polymorphisms on serum levels of cortisol and aldosterone among different phases of the normal menstrual cycle in 51 non-pregnant healthy Japanese female volunteers (22 ± 1 years old). The menstrual cycle was divided into three phases: premenstrual phase (14 days preceding the ... more

T. Nakamura; N. Okamura; M. Yagi; H. Omatsu; M. Yamamori; A. Kuwahara; K. Nishiguchi; M. Horinouchi; K. Okumura; T. Sakaeda
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ABO blood group; ABO gene; Brazilian population; DNA polymorphism; Genetic polymorphism; Leukemia

The ABO blood group is the most important blood group system in transfusion medicine and organ transplantation. To date, more than 160 ABO alleles have been identified by molecular investigation. Almost all ABO genotyping studies have been performed in blood donors and families and for investigation of ABO subgroups detected serologically. The aim of the ... more

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Genetic polymorphism; Hypertension; Mongolian; Peroxisome proliferator-activated receptor gamma coactivator-1 alpha

We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cholesterol, and fasting plasma glucose were measured, and body mass ... more

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CCAAT/enhancer-binding protein alpha (C/EBPa) is an essential transcriptional factor regulating the differentiation of adipocytes. We report a novel single nucleotide polymorphism (C271A) of the C/EBPa gene in six indigenous Chinese cattle breeds using PCR-SSCP and DNA sequencing methods. Allele frequencies were investigated and evaluated by the χ2 test in 817 individuals; all ... more

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ESRD; Genetic polymorphism; Interleukin; VNTR

Variable number of tandem repeats (VNTR) polymorphism in the interleukin 4 (IL-4) gene has been associated with end-stage renal disease (ESRD) subjects in many different populations, although with conflicting results. We determined the 70 bp of VNTR polymorphism at intron 3 of the IL-4 gene in Malaysian ESRD subjects. Buccal cells were collected from 160 case and 160 control subjects; ... more

R. Vasudevan; M.N. Norhasniza; I. Patimah
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Association study; Genetic polymorphism; Psoriasis; Serotonin transporter; Serotonin transporter gene-linked polymorphic region; Thai population

The serotonin transporter (5-HTT) is of great significance in the control of the serotonergic system, and its expression is known to be upregulated in psoriasis, a chronic or recurrent inflammatory skin disease. We investigated a possible association between the 5-HTT gene-linked polymorphic region (5-HTTLPR) and psoriasis in a Thai population. One hundred and fifty-six psoriatic ... more

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