Research Article

Related GMR Articles

11/22/2013
Cytokines; Gold nanoparticles; In vivo toxicity; Inflammation; Rats

Most studies have used in vitro systems to test inflammatory responses of nanoparticles; these may not reflect the real biological response of body organs. In fact, certain nanoparticles have provoked opposite effects under in vitro and in vivo conditions. Current understanding of the biocompatibility of gold nanoparticles is controversial. We studied the acute ... more

H.A. Khan; M.A.K. Abdelhalim; A.S. Alhomida; M.S.Al Ayed
08/28/2014
Interleukin; Peroxisome proliferator-activated receptor; Rats; Tumor necrosis factor-α

The objective was to study peroxisome proliferator-activated receptor gamma (PPARγ) agonist pioglitazone regulation effect and its mechanism of expression of cytokines on acute gouty arthritis synovial in rats. Rats with unilateral ankle were injected with artificial monosodium urate (MSU) crystals to make the acute gouty arthritis model. Taking the synovium 48 h after the injection of ... more

R.C. Wang; D.M. Jiang
07/02/2014
Abnormal Savda syndrome; Ischemia-reperfusion injury; Munziq; Rats

To investigate the effects of different doses of abnormal Savda Munziq on myocardial ischemia-reperfusion injury (MI/RI) in rats with the abnormal Savda syndrome, 50 abnormal Savda animal models were randomly divided into a control group, a model group, a high-dose group, a middle-dose group, and a low-dose group, with each group containing 10 rats. The enzyme-linked immunosorbent assay ... more

A. Maimaitiaili; A. Shabiti; M. Abudureheman; Z. Musha; Q. Jun; G. Maimaitiaili; A. Aibibula; H. Upur
06/18/2015
Different stages; HIF-1α; Rats; Thromboangiitis obliterans

We investigated the expression and effects of hypoxia-inducible factor-1α (HIF-1α) in rat thromboangiitis obliterans (TO). Rats were divided into sham and model groups. The model group was further divided into groups based on observation duration. Lauric acid was injected below an artery clamp to simulate TO in the model group; saline was used in the sham group. Clamps were removed 15 min ... more

T. He; B.H. Qu; D.L. Wang; M. Hu
04/17/2015
Acute spinal cord injury; Interleukin-6; Ketamine; Malondialdehyde; Rats; Tumor necrosis factor-α

The aim of this study was to investigate the neuroprotective effects of ketamine during acute spinal cord injury in rats. Sprague Dawley (SD) rats (N = 70) were randomly divided into three groups: sham-operated (N = 10), control (N = 30), and treatment (N = 30) groups. The moderate spinal cord injury model was established. After injury, the sham-operated group received no drug, the ... more

S.H. Tang; J.G. Yu; J.J. Li; J.Y. Sun
04/10/2015
Ischemia preconditioning; Ischemia-reperfusion injury; Liver transplantation; Rats

We explored the protective effect of ischemia preconditioning (IP) on ischemia-reperfusion injury in rat liver transplantation. An orthotopic liver transplantation model was utilized in the study. A total of 54 Sprague-Dawley rats were divided into a control group (group A, no liver transplantation), liver transplantation group (group B, heparin Ringer’s lactate solution was perfused via ... more

Z.S. Qing; X.S. Zhang; C.C. Gao; W.D. Liu; T.F. Xia; K. Wu; L.Q. Pang
03/20/2015
Heat stress; HSP70; Myocardial cells; Rats

To investigate the mechanism of sudden death as a result of stress-induced damage to heart tissue and myocardial cells and to investigate the cardioprotective role of Hsp70 during heat stress, the distribution and expression of Hsp70 was evaluated in the heart cells of heat-stressed rats in vivo and heat-stressed H9c2 cells in vitro. After exposure to heat stress at 42°C ... more

H.B. Chen; X.C. Zhang; Y.F. Cheng; A. Abdelnasir; S. Tang; N. Kemper; J. Hartung; E.D. Bao
02/13/2015
Free radical; Nimodipine; Peroxidase; Propylene glycol; Rats; Spinal cord injury

We evaluated the potentially protective effect of nimodipine on rat spinal cord injury. Sprague-Dawley rats received spinal cord injury, and were separated into nimodipine (N = 12) and saline groups (N = 12). Within 1 h of the injury, rats were treated intraperitoneally with nimodipine (1.0 mg/kg) or an equal amount of saline. Treatment was performed 3 times a day for 1 week. Operation ... more

Y.F. Jia; H.L. Gao; L.J. Ma; J. Li
07/19/2012
C-reactive protein; Inflammatory reaction; Intracerebral hemorrhage; Polymorphism; Resistin

We examined a possible relationship -420C>G SNP of the resistin gene with plasma resistin and C-reactive protein concentrations in intracerebral hemorrhage. Three hundred and forty-four Chinese Han patients with intracerebral hemorrhage and 344 age- and gender-matched healthy controls were included in our study. Plasma resistin and C-reactive concentrations were measured and SNP -420C ... more

X.Q. Dong; Q. Du; W.H. Yu; Z.Y. Zhang; Q. Zhu; Z.H. Che; H. Wang; J. Chen; S.B. Yang; J.F. Wen