Research Article

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10/05/2007
Genetic polymorphism; Leptin; Leptin receptor; Obesity; β3-adrenergic receptor

Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors. The adrenergic receptor β3 (β3-AR), leptin (LEP) and leptin receptor (LEPR) genes have been intensively evaluated in the search of variants that could be related to obesity and its cardiometabolic complications. The results of most of these studies have ... more

S.F.P. Duarte; E.A. Francischetti; V.A. Genelhu; P.H. Cabello; M.M.G. Pimentel
09/09/2011
Aging; Apolipoprotein E; Brazilian-Japanese elderly; Cardiovascular risk; Longevity; Obesity

Study of immigrant populations may contribute to a better understanding of the epidemiology of diseases associated with the aging process. We examined the prevalence of cardiovascular risk factors, including apolipoprotein E (ApoE) polymorphism, in elderly subjects who were born in Japan, migrated to South Brazil and have lived in that region for over 40 years, versus a group of elderly, ... more

N. Terra; Y. Moriguchi; L. Bittencourt; R.S. Trois; J.E.C. Piccoli; I.B.M. Cruz
06/07/2011
BMI; Leptin; MC4R gene; Obesity

Mutations in the melanocortin-4 receptor (MC4R) are associated with severe obesity, independent of their effect on cortisol or thyroid-stimulating hormone levels. We examined a morbidly obese male (BMI = 62 kg/m2) with a binge-eating disorder and eight family members for mutations in the MC4R gene and potential differences in leptin levels. Fifty healthy individuals served as ... more

S. Buchbinder; U. Bärtsch; M. Müller; M. Zorn; P.P. Nawroth; T. Schilling
07/20/2010
Adiponectin; Adrenergic receptor; Cardiometabolic risk factor; Obesity; Polymorphism

We determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers ... more

V.A. Genelhu; E.A. Francischetti; S.F.P. Duarte; B.M.J. Celoria; R.C. Oliveira; P.H. Cabello; M.M.G. Pimentel
12/19/2013
Angiotensin-I coverting enzyme; Hyperlipidemia; Multifactorial disease; Obesity; Smoking

Coronary artery disease (CAD) is a multifactorial disease influenced by genetic and environmental factors. Major risk factors of CAD are hypertension, hyperlipidemia, smoking, family history and obesity. Also polymorphisms in the angiotensin-I converting enzyme (ACE) gene can associate with CAD. The relationship between ACE polymorphisms and other risk factors is not well ... more

A.I. Güney; D. Ergec; D. Kırac; H. Ozturhan; M. Caner; G. Koc; C. Kaspar; K. Ulucan; M. Agirbasli
11/18/2013
-308G>A; Breast cancer; Mexican population; Obesity; Risk factor; Tumor necrosis factor alpha

The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with ... more

G. Flores-Ramos; E. De Dios; A.M. Puebla-Pérez; L.E. Figuera-Villanueva; A. Ramos-Silva; R. Ramírez-Patiño; J.I. Delgado-Saucedo; E. Salas-González; G.M. Zúñiga-González; A. Alonzo-Rojo; I. Gutiérrez-Hurtado; M.P. Gallegos-Arreola
09/27/2013
Exercise; Genetic risk factor; Nutritional intervention; Obesity

We evaluated the response of individuals with metabolic syndrome to lifestyle modification intervention and examined the influence of the 48867A>C (Asp358Ala) IL6R (rs2228145) polymorphism on this response. Participants were randomly divided into two groups: NI, nutritional intervention; NIE, nutritional intervention and exercise practice. Intervention lasted three months and ... more

V.R.A. Vargas; S.L. Bonatto; F.E. Macagnan; A.M.P. Feoli; C.S. Alho; N.D.V. Santos; V.M. Schmitt
05/13/2013
Adipose tissue; Evodiamine; Lipid; Liver; Mice; Obesity

Evodiamine is the main active alkali of Wu Zhuyu, a widely distributed Chinese herb. It plays an important role in the regulation of body fat deposition. In this study, we aimed to investigate the effect of evodiamine administration on the expression of genes involved in lipid metabolism in the liver and adipose tissue. Fasted mice were subcutaneously injected with evodiamine (37°C, 20 ... more

D.F. Jiang; X.G. Zhang; H.L. Yang; C. Sun
09/03/2012
Developmental delay; GPC5; Obesity; Overgrowth; SH2B1

Chromosome microarray analysis of patients with developmental delay has provided evidence of small deletions or duplications associated with this clinical phenotype. In this context, a 7.1- to 8.7-Mb interstitial deletion of chromosome 16 is well documented, but within this interval a rare 200-kb deletion has recently been defined that appears to be associated with obesity, or ... more

A.M. George; J. Taylor; D.R. Love
08/31/2012
Cell cycle; Coexpression network; Obesity; Pathway enrichment analysis

The aim of this study was to identify related genes and the underlying molecular mechanisms in obese patients who show a series of clinical and metabolic abnormalities known as metabolic syndrome. We identified expression profiles through a coexpression network. In addition, a similarity matrix and expression modules were constructed based on domain and pathway enrichment analysis. The ... more

J.F. Zhang; G.Y. Yao; Y.H. Wu

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