Research Article

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Acute kidney injury; Bone marrow-derived mesenchymal stem cells; Cell differentiation; Cytokines; Erythropoietin

We investigated the effect of erythropoietin (EPO) on differentiation and secretion of bone marrow-derived mesenchymal stem cells in an acute kidney injury microenvironment. Acute kidney injury mouse models were prepared. Both renal cortices were then immediately collected to produce the ischemia/reperfusion kidney homogenate supernatant. The morphological and ultrastructural changes in ... more

N.M. Liu; J. Tian; W.W. Wang; G.F. Han; J. Cheng; J. Huang; J.Y. Zhang
11/22/2013
Cytokines; Gold nanoparticles; In vivo toxicity; Inflammation; Rats

Most studies have used in vitro systems to test inflammatory responses of nanoparticles; these may not reflect the real biological response of body organs. In fact, certain nanoparticles have provoked opposite effects under in vitro and in vivo conditions. Current understanding of the biocompatibility of gold nanoparticles is controversial. We studied the acute ... more

H.A. Khan; M.A.K. Abdelhalim; A.S. Alhomida; M.S.Al Ayed
12/17/2012
Cytokines; Gingiva; Periodontitis; Real-time polymerase chain reaction

Periodontal disease is one of the most prevalent oral diseases. An association between this disease and pregnancy has been suggested, but available findings are controversial. We evaluated the expression levels of interleukins (IL-1β and IL-6), tumor necrosis factor-alpha (TNF-α), and inducible nitric oxide synthase (iNOS) in pregnant women with and without periodontal disease in ... more

C.C.M. Otenio; I. Fonseca; M.F. Martins; L.C. Ribeiro; N.M.S.P. Assis; A.P. Ferreira; R.A. Ribeiro
01/21/2014
BMMSCs; Cytokines; Hepatic differentiation; Hepatocyte; MAPK

Our research demonstrated the potential for mouse bone marrow mesenchymal stem cells (mBMMSCs) to differentiate into hepatocytes in vitro and in vivo. However, the exact mechanism of this process remains unknown. In this study, we investigated the role of the mitogen-activated protein kinase (MAPK) cell-signaling pathway in the differentiation of mBMMSCs into hepatocytes ... more

T. Lu; C. Yang; H. Sun; J. Lv; F. Zhang; X.J. Dong
02/03/2015
Cattle; Cross-reactivity; Cytokines; Goat; Human; Sheep

Eleven commercially available PE-labeled anti-human (IL-1-α, IL-6, IL-8, TNF-α, IL-17A, IL-5, IL-10, IL-12 and IL-13) and anti-mouse (IL-10, TNF-α) cytokine monoclonal antibodies (mAbs) were tested for cross-reactivity with cattle, goat, and sheep cytokines. Cross-reactivity was assessed by comparative analysis with the standard reactivity of the target species. Our data demonstrated ... more

E.M.S. Dorneles; M.S.S. Araújo; A. Teixeira-Carvalho; O.A. Martins-Filho; A.P. Lage
03/31/2003
Antigens; Cytokines; Lactococcus lactis; Mucosal vaccine; Secretion

Lactic acid bacteria (LAB), widely used in the food industry, are present in the intestine of most animals, including humans. The potential use of these bacteria as live vehicles for the production and delivery of heterologous proteins of vaccinal, medical or technological interest has therefore been extensively investigated. Lactococcus lactis, a LAB species, is a potential ... more

S. Nouaille; L.A. Ribeiro; A. Miyoshi; D. Pontes; Y. Le Loir; S.Costa Oliveira; S.Costa Oliveira; P. Langella; V. Azevedo
10/08/2014
Cytokines; GILZ; Glucocorticoid; Protein metabolism; Sepsis

Sepsis is a complex inflammatory response to infection, associating with dramatic metabolic disorders. Although the mechanisms of immune response during sepsis have been largely clarified, current studies rarely pay attention to the disordered protein metabolism in sepsis. In this study, L6 rat skeletal muscle cells treated with serum from septic rats were used as an in vitro ... more

J. Xiong; L. Xu; W.M. Qu; Z.L. Li; Z.H. Shang; Y.H. Li; S.H. Yang; Z.H. Yang
04/17/2015
C-Jun N-terminal kinase; Cytokines; Extracellular receptor kinase; Jurkat; Silver-gold nanoparticles; U937

Silver nanopaticles (AgNPs) and gold nanoparticles (AuNPs) have various applications in medical healthcare and various biological properties such as anti-inflammation, anti-cancer, and anti-angiogenesis. In this study, we investigated the effect of AgNPs and AuNPs on cytokine production via the mitogen-activated protein kinase pathway in leukemic cell lines (T-lymphocytic Jurkat and ... more

C. Parnsamut; S. Brimson
12/19/2013
Cyclosporine A; Liver transplantation; Th1/Th2

In this study, early expressions of peripheral blood Th1 and Th2 cells were documented following rat liver transplantation and related to immune status. Rats were divided into 3 groups: group A (control): syngeneic transplantation (Brown Norway (BN) → BN); group B: allogeneic transplantation + cyclosporine A (CsA); group C: allogeneic transplantation (Lewis → BN). Flow cytometry was used ... more

Z.L. Yang; K. Cheng; H.G. Sun; W.W. Zou; M.M. Wu
09/27/2013
Interleukin-10; Liver regeneration; Liver transplantation; Tumor necrosis factor

To study the impact of cold ischemia on tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) expression after liver transplantation, a stable model of partial liver transplantation in rats was established. The experimental animals were divided into the following groups: a partial hepatectomy control group, a group that received partial liver transplantation after 30 min of cold ... more

Q.A. Qi; Z.Y. Yang; K.S. Ma; Q. Lu; S.G. Wang; X.W. Li; F. Xia; W. Liu; P. Bie

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