Research Article

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01/19/2010
Elderly; HDL cholesterol; Lipoprotein lipase; Polymorphism; Triglycerides

Lipoprotein lipase is essential for triglyceride hydrolysis. The polymorphisms S447X in exon 9 and HindIII in intron 8 have been associated with lower triglyceride levels and lower cardiovascular risk in adult men. We examined the association of these lipoprotein lipase polymorphisms with high-density lipoprotein (HDL) and triglyceride levels in elderly men. Blood samples were ... more

L.M.Q. Araújo; M.S. Cendoroglo; C.O. Gigek; E.S. Chen; deA.C. Smith
12/19/2013
Cerebrovascular disease; Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism; Stroke

Several independent studies have reported the role of the methylenetetrahydrofolate reductase gene (MTHFR) A1298C polymorphism in strokes, but the results are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed in the present study. In this meta-analysis, a total of 13 studies, including 1974 cases and 2660 controls, were selected ... more

Q.Q. Lv; J. Lu; W. Wu; H. Sun; J.S. Zhang
12/13/2013
Mastitis; PCR-PIRA; PCR-RFLP; Percentage of fat; PGLYRP-2 gene; Polymorphism

Peptidoglycan recognition protein 2 (PGLYRP-2), which belongs to the PGRP family, is the only member that has no direct bactericidal activity but has N-acetylmuramoyl-l-alanine amidase activity. This feature of PGLYRP-2 indicates that it may play an important role in eliminating the pathogen associated molecular pattern (PAMP), such as peptidoglycan (PGN), which can reduce ... more

H.L. Wang; Z.X. Li; L. Chen; J. Yang; L.J. Wang; H. He; F.B. Niu; Y. Liu; J.Z. Guo; X.L. Liu
12/13/2013
Beef cattle; Carcass and meat quality traits; Myf6; MyoD1; PCR-RFLP; Polymorphism

Myogenic determination factor 1 (MyoD1) and myogenic factor 6 (Myf6) genes belong to the myogenic differentiation (MyoD) gene family, which play key roles in growth and muscle development. The study aimed to investigate the effects of variants in cattle MyoD1 and Myf6 on carcass and meat traits. We screened single nucleotide polymorphisms (SNPs ... more

X.H. Du; Q.F. Gan; Z.R. Yuan; X. Gao; L.P. Zhang; H.J. Gao; J.Y. Li; S.Z. Xu
04/26/2013
CCND1 gene; Esophageal cancer; Genetic association; Meta-analysis; Polymorphism

The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the allelic/genotypic ... more

W. Cai; Z.T. Wang; J. Zhong; Y. Zhang
12/11/2013
Growth traits; Insulin-like growth factor II; Polymorphism; Yak

Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth and is involved in stimulating fetal cell division, differentiation, and metabolic regulation. IGF-II is considered a candidate gene for genetic markers of growth and carcass traits. Therefore, in this study, the associations of single nucleotide polymorphisms (SNPs) in the IGF-II gene region with growth and ... more

Y.F. Zeng; X.Z. Ding; S.R. Cheng; S.J. Yu
01/04/2013
Hepatocellular carcinoma; MIF-794CATT; Polymorphism; Promoter

Hepatocellular carcinoma (HCC) is one of the most common worldwide malignancies. A relative complete diagnosis system for primary carcinoma of liver has already been established, but the surgical prognosis for HCC, which depends mainly on postoperative pathological classification and data of recurrence and metastasis, lacks valid experimental indicators. Macrophage migration inhibition ... more

T. Yuan; C. Tang; M. Chen; S. Deng; P. Chen
12/13/2013
CCND1; Esophageal squamous cell carcinoma; Polymorphism; PTEN

Cyclin D1 (CCND1) plays a significant role in G1-S transition of cell cycle, and phosphatase and a tensin homologue (PTEN) negatively regulate cell cycle through phosphatidylinositol 3-kinase (PI3K)/AKT signaling. CCND1 and PTEN genetic polymorphisms might induce susceptibility to the occurrence of esophageal squamous cell carcinoma (ESCC). Three hundred and four ESCC patients and 413 ... more

Y. Jang; S.A. Lu; Z.P. Chen; J. Ma; C.Q. Xu; C.Z. Zhang; J.J. Wang
12/10/2013
Microsatellite; Oplegnathus fasciatus; Polymorphism

The rock bream fish Oplegnathus fasciatus is one of the most popular aquaculture species in China. In the present study, 15 novel polymorphic microsatellite loci were isolated and characterized from a wild population of O. fasciatus from the Zhoushan coast of China. The number of alleles per polymorphic locus ranged from 4 to 9 in a sample of 30 individuals. Observed and ... more

X.X. Sun; D.D. Xu; B. Lou; S.L. Li; W. Zhan; Y.R. Zhang; J. Xin
12/10/2013
COMT; Endometrial cancer; Meta-analysis; Polymorphism

Catechol-O-methyltransferase (COMT) is a critical enzyme to detoxify the carcinogenic catechol estrogen and the Val158Met polymorphism of COMT could influence its enzymatic activity. Recent epidemiological studies have investigated the correlation of COMT Val158Met polymorphism with endometrial cancer risk; however, the results are inconsistent. To better evaluate the role of ... more

G. Lin; J. Zhao; J. Wu; A. O; W.H. Zhang; Y. Zhang; L. Yu

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