Research Article

Related GMR Articles

11/16/2010
CYP; GST; p53; Polymorphism; susceptibility; Thyroid disease

Specific genotypes appear to be related to the development of thyroid disease. We examined whether polymorphisms of the genes CYP1A1, GSTM1, GSTT1, and TP53 at codon 72 are associated with increased risk for thyroid nodules. Blood samples were obtained from 122 thyroid patients with nodules and from 134 healthy control individuals from Goiânia city, GO ... more

A.A.S. Reis; D.M. Silva; M.P. Curado; A.D. da Cruz
11/07/2013
Hepatocellular carcinoma; miR-146aG>C rs2910164; miR-499A>G rs3746444; susceptibility

We conducted a case-control study of a possible association of miR-499A>G rs3746444 and miR-146aG>C rs2910164 with risk of hepatocellular carcinoma. Samples from 172 hepatocellular carcinoma patients and 185 cancer-free controls were collected from October 2008 to December 2011. PCR-RFLP analysis was performed to determine the polymorphisms in each individual. The MAFs of miR-146aG ... more

Y.F. Shan; Y.H. Huang; Z.K. Chen; K.T. Huang; M.T. Zhou; H.Q. Shi; Q.T. Song; Z.P. Yu; A.M. Deng; Q.Y. Zhang
09/19/2013
Association analysis; Genetic polymorphisms; susceptibility; Toll-like receptor 4; Type 2 diabetes mellitus

Toll-like receptor 4 (TLR4) is potentially an important gene affecting the susceptibility to type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate whether genetic polymorphisms of the TLR4 gene are associated with T2DM susceptibility. This potential association was analyzed in 668 T2DM patients and 672 healthy controls by polymerase chain reaction- ... more

X.D. Fu; X.Q. Sun; H.Y. Wang; J.F. Guo; G.Z. Zhang; Q.H. Xu
05/21/2013
Ankylosing spondylitis; Genetic polymorphisms; Interleukin-1 receptor antagonist; Meta-analysis; susceptibility

We made a Human Genome Epidemiology review and meta-analysis to examine a possible association between interleukin-1 receptor antagonist (IL-1RN) polymorphisms and susceptibility to ankylosing spondylitis (AS). Studies of IL-1RN polymorphisms and susceptibility to AS were found by searching the Pubmed, Cochrane library, Embase, Web of Science, Springerlink, CNKI, and CBM databases. Data ... more

G.X. Jin; J.Z. Duan; W.L. Guo; L. Li; S.Q. Cui; H. Wang
05/13/2013
Cancer; Caspase 3; Genetic polymorphism; Meta-analysis; susceptibility

Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Therefore, we made a Human Genome ... more

S. Yan; Y.Z. Li; X.W. Zhu; C.L. Liu; P. Wang; Y.L. Liu
12/17/2012
Breast cancer; DNMT; Single nucleotide polymorphism; susceptibility

Patterns of DNA methylation are established and maintained by a family of DNA methyltransferases (DNMTs). Aberrant promoter DNA methylation of tumor suppressor genes is found in breast cancer. Association studies between DNMT gene polymorphisms and breast cancer in various populations have reported inconsistent results. This study assessed the associations of single nucleotide ... more

M.Y. Sun; X.X. Yang; W.W. Xu; G.Y. Yao; H.Z. Pan; M. Li
11/26/2012
Cancer; CASP-10; Genetic polymorphisms; Meta-analysis; susceptibility

We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529*T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). ... more

S. Yan; Y.Z. Li; J.W. Zhu; C.L. Liu; P. Wang; Y.L. Liu
11/12/2012
Gastric cancer; Meta-analysis; Polymorphism; susceptibility; XRCC1

Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a ... more

B.M. Liu; T.M. Liu; B.S. You; H.Y. You; J. Yang; L. Li; Y.C. He
06/29/2012
Keloid; Meta-analysis; p53 codon 72 polymorphism; susceptibility

Although there is evidence suggesting genetic susceptibility for keloids, studies investigating the association between Arg72Pro polymorphism in the P53 gene and tendency to form keloids have given variable results. We made a meta-analysis of the effects of P53 Arg72Pro polymorphism on keloid risk in the Chinese population by conducting searches of the published literature in ... more

Y. Wu; B. Wang; Y.H. Li; X.G. Xu; Y.J. Luo; J.Z.S. Chen; H.C. Wei; X.H. Gao; H.D. Chen
05/15/2012
Killer cell immunoglobulin-like receptor; Polymorphism; Pulmonary tuberculosis; susceptibility

Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese Han. We analyzed 15 KIR genes in 109 pulmonary tuberculosis ... more

C. Lu; Y.J. Shen; Y.F. Deng; C.Y. Wang; G. Fan; Y.Q. Liu; S.M. Zhao; B.C. Zhang; Y.R. Zhao; Z.E. Wang; C.Z. Zhang; Z.M. Lu

Pages