Research Article

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10/06/2006
Gene polymorphisms; MHC; OLA; Ovar-Mhc; Review; Sheep; Structure

The major histocompatibility complex (MHC) in sheep, Ovar-Mhc, is poorly characterised, when compared to other domestic animals. However, its basic structure is similar to that of other mammals, comprising class I, II and III regions. Currently, there is evidence for the existence of four class I loci. The class II region is better characterised, with evidence of one DRA, four ... more

V.S.R. Dukkipati; H.T. Blair; D.J. Garrick; A. Murray
09/29/2009
Cattle; Effective population size; Inbreeding; Pigs; Sheep; Software

Genetic variation provides a basis upon which populations can be genetically improved. Management of animal genetic resources in order to minimize loss of genetic diversity both within and across breeds has recently received attention at different levels, e.g., breed, national and international levels. A major need for sustainable improvement and conservation programs is accurate ... more

E. Groeneveld; Bv.d. Westhuizen; A. Maiwashe; F. Voordewind; J.B.S. Ferraz
09/01/2009
Caseous lymphadenitis; Corynebacterium pseudotuberculosis; Goat; Sheep; Vaccine
F.A. Dorella
08/16/2012
Candidate gene; Domain; Homeodomain; Sheep; TTF-1

Thyroid transcription factor-1 (TTF-1), a member of the Nkx2 family of homeodomain-containing proteins, is involved in binding to and in activating the promoters of several important genes in the thyroid, lungs, and brain, and in regulating expression of these tissue-specific genes. We investigated potential roles of sheep (Ovis aries) TTF-1 in regulating cell fate and organ ... more

L.P. Zhang; B.Y. Ma; F.X. Han; H.L. Wan; J.P. Wu; L.H. Yu; X.R. Wang; J.Y. Zhu
06/21/2012
ARMS-PCR; Genotyping; mutations; PCR-SSCP; PRNP alleles; Sheep

Anti-scrapie breeding programs have been initiated to screen for scrapie-resistant sheep based on ovine prion protein gene (PRNP) genotypes at codons 136, 154 and 171 in many countries, especially European Union member states. However, investigation of sheep PRNP genotypes is limited in China, despite the large number of sheep breeds. We analyzed 432 sheep of five different breeds from ... more

C.L. Zhao; R. Wu; L. Liu; F.D. Li; X.L. Zhang; C. Wang; F. Wang; X.L. Diao; H.W. Guan; X. Wang; L. Zhou
04/03/2012
Gene expression; Hemi-nested PCR; Indirect immunofluorescence; Sheep

The CD44 family belongs to a larger group of hyaluronic acid-binding proteins and plays important roles in oocyte maturation, fertilization and preimplantational embryo development. We analyzed the CD44 receptor in sheep oocytes and embryos. Immature oocytes (N = 66) were obtained from a local abattoir; mature oocytes (N = 35) and embryos (N = 41) were obtained by laparotomy from adult ... more

J.V. Luz; A.S. Alcântara-Neto; R.I.T.P. Batista; J.M.G. Souza; D.I.A. Teixeira; L.M. Melo; V.J.F. Freitas
06/09/2014
Genetic diversity; Geographic distance; Pairwise distance; Sheep

This study investigated geographic and pairwise distances among seven Chinese local and four introduced sheep populations via analysis of 26 microsatellite DNA markers. Genetic polymorphism was rich, and the following was discovered: 348 alleles in total were detected, the average allele number was 13.38, the polymorphism information content (PIC) of loci ranged from 0.717 to 0.788, the ... more

J.B. Liu; Y.J. Yue; X. Lang; F. Wang; X. Zha; J. Guo; R.L. Feng; T.T. Guo; B.H. Yang; X.P. Sun
04/30/2014
Keratin-associated protein; Polymorphism; Sheep; Wool fiber diameter

High glycine-tyrosine proteins (HGTPs), also known as keratin-associated proteins (KAPs), play a key role in the major structures and mechanical properties of wool fiber. Sheep HGTPs consist of three multigene families: KAP6, KAP7, and KAP8 genes. Polymorphisms of these three genes have been proposed to have important effects on wool fiber traits. The aim of the present study was to ... more

Y.X. Liu; G.Q. Shi; H.X. Wang; P.C. Wan; H. Tang; H. Yang; F. Guan
03/30/2015
Colostrum; Fcgrt; Genetic polymorphism; IgG; Sheep

The neonatal Fc receptor (FcRn) plays an important role in regulating IgG homeostasis in the body and passive protection to the offspring. Changes in FcRn expression levels caused by genetic polymorphisms of Fcgrt, which encodes FcRn, may lead to inter-individual differences in colostrum IgG levels in sheep. In this study, we sequenced the FcRn partial heavy chain from 179 sheep ... more

Z.H. Tian; F. Shi; F.G. Zhong; D.P. Bai; X.Y. Zhang
02/06/2015
Gene expression; Sheep; Skeletal muscle; Transcriptome

The objectives of the present study were to identify additional genes that may play important roles in the regulation of skeletal muscle growth and development, and to provide fundamental information for understanding the underlying molecular mechanisms. Eighteen cDNA libraries were constructed from the longissimus muscle of Polled Dorset (PD) and Small-tailed Han (SH) fetuses. To reveal ... more

N. Liu; J.N. He; W.M. Yu; K.D. Liu; M. Cheng; J.F. Liu; Y.H. He; J.S. Zhao; X.X. Qu

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