Research Article

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Oxidative stress, which poses a threat to reproductive health, causes many serious female reproductive diseases. In this study, we investigated whether proanthocyanidins (PC) have a protective effect against oxidative stress-induced ovarian damage. Forty female ICR mice were randomized into 4 groups: a control group, a control plus PC group, a 3-nitropropionic acid (3-NPA) group, and a 3- ... more

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Lactation; Leptin; Pregnancy; Rat; Virgin

Leptin is expressed in various tissues, suggesting that this protein is effective not only at the central nervous system level, but also peripherically. Recent studies have shown leptin production by other tissues, including the placenta, stomach, and mammary tissues, but there is no information available concerning expression levels of leptin in the rat mammary gland at different activation ... more

Y.Y. Wang; Y.L. Wang; H.P. Li; H.S. Zhu; Q.D. Jiang; L. Zhang; L.F. Wang; L.Q. Han; K. Zhong; Y.J. Guo; W.F. Lu; H.J. Li; G.Y. Yang
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To understand the mechanism underlying the sudden animal death caused by acute heart failure during heat stress, the relationships among the heat-induced pathological changes and apoptosis and the variations in the levels of protective Hsp90α and its mRNA in the heat-stressed primary myocardial cells of neonatal rats in vitro were studied by cytopathological observation, ... more

A. Islam; Y.J. Lv; A. Abdelnasir; B. Rehana; Z.J. Liu; M. Zhang; S. Tang; Y.F. Cheng; H.B. Chen; J. Hartung; E.D. Bao
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Duodenum; FoxO; IGF-1; Rat; Signaling pathway

The insulin growth factor 1/phosphatase and tensin homologue deleted on chromosome 10/Akt/forkhead box (IGF-1/PTEN/Akt/FoxO) signaling pathway reportedly exhibits gastroprotective effects by reducing water immersion and restraint stress (WRS)-induced gastric mucosal cell apoptosis. We examined the expression and localization of IGF-1, PTEN, Akt, and FoxO proteins, caspase-3 activity, and ... more

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Heat stress; Hsp60; In vivo and in vitro cell culture; Myocardial cell; Rat

To investigate the protective role of Hsp60 against stress damage and its role in the sudden death of stressed animals, changes in the levels of Hsp60 protein and hsp60 mRNA of myocardial cells in vivo and in vitro were studied. In addition, the relationship between Hsp60 expression and heat-induced damage was also studied. Rats were exposed to a temperature of ... more

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Cardiovascular protection; Hyperlipidemia; Intermedin; Ischemia-reperfusion injury; Myocardial; Rat

Hyperlipidemia is a well-established risk factor for the development of coronary atherosclerosis, while intermedin (IMD) has been identified as a novel calcitonin/calcitonin gene-related peptide family member involved in cardiovascular protection. However, whether IMD protects against hyperlipidemia-associated myocardial ischemia/reperfusion (MI/R) injury is unknown. We established a ... more

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Acrylonitrile; Apoptosis; Brain neuron; Neuron morphology; Rat

This study aimed to evaluate the effects of acrylonitrile (ACN) on neuronal morphology and apoptosis in rats. An ACN solution was administered to Wistar rats by gavage at doses of 0, 5, 10, or 20 mg/kg, 5 days a week for 13 weeks. The morphology of neurons and the presence of apoptosis was examined by light and electron microscope, DNA electrophoresis, immunohistochemistry, and terminal ... more

C.Z. Li; L.A. Tse; Y.L. Zhou; W. Fan; M. Li; I.T.S. Yu; T.Y. Jin
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ACE; ACE2; Kidney injury; Negative regulation; Rat

Angiotensin-converting enzyme 2 (ACE2), a newly discovered carboxypeptidase in the renin-angiotensin system (RAS), antagonizes ACE activity and plays an active role during tissue injury. Yet the mechanism of its action is not well known. Using a streptozotocin (STZ)-induced renal injury rat model, we investigated the relationship between renal injury and the antagonism between ACE and ... more

C. Ma; H. Xin; X.Y. Jiang; Y.X. Wang; Y.S. Zhang

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