Research Article

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12/08/2011
Endometrial cancer; Meta-analysis; p53 gene; Polymorphism; susceptibility

Polymorphisms of the p53 gene have been associated with susceptibility to endometrial cancer. However, whether there is a specific association is still controversial. We investigated a possible association between p53 codon 72 polymorphism and endometrial cancer risk by conducting a meta-analysis. Publications addressing this association were selected from the Pubmed, Embase and CBM ... more

Y. Gu; X. Zhou; S.L. Zhang
11/12/2012
Gastric cancer; Meta-analysis; Polymorphism; susceptibility; XRCC1

Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a ... more

B.M. Liu; T.M. Liu; B.S. You; H.Y. You; J. Yang; L. Li; Y.C. He
10/20/2014
Atrial fibrillation; KCNE1; Meta-analysis; Polymorphism; susceptibility

KCNE1, a membrane protein that spans the membrane once is responsible for modulating potassium channel functions and plays an important role in the etiology of arrhythmia. Emerging evidence indicates that a common polymorphism (112G>A; rs1805127 G>A) in the KCNE1 gene contributes to atrial fibrillation (AF) risk; however, these studies showed inconclusive results. In this ... more

H.G. Han; H.S. Wang; Z. Yin; H. Jiang; M. Fang; J. Han
07/25/2014
Digestive tract cancer; Hypoxia inducible factor-1α; Meta-analysis; Polymorphism

Many existing studies have demonstrated that common polymorphisms in the hypoxia inducible factor-1α (HIF-1A) may contribute to the development of digestive tract cancers, but individually published studies showed inconclusive results. This meta-analysis aimed to derive a precise estimation of the relationships between HIF1A Pro582Ser polymorphism and the risk of ... more

J. Xu; L. Xu; L.T. Li; Q. You; L.S. Cha
12/08/2011
Colorectal cancer; Meta-analysis; Polymorphism; VEGF

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains controversial. We made a meta-analysis of the association ... more

L.P. Zhou; H. Luan; X.H. Dong; G.J. Jin; D.L. Man; H. Shang
12/08/2011
Head and neck cancer; Meta-analysis; Polymorphism; XPD

Several studies have investigated the association between Lys751Gln polymorphism in the xeroderma pigmentosum group D (XPD) gene and risk of head and neck cancer; however, the published results are conflicting. We conducted a meta-analysis that comprised 15 published case-control studies examining the association of head and neck cancer risk with XPD Lys751Gln ... more

H. Yuan; Y.M. Niu; R.X. Wang; H.Z. Li; N. Chen
12/15/2011
Human leukocyte antigen; Meta-analysis; Polymorphism; Psoriasis; Risk

Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a meta-analysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 psoriasis patients and 3297 healthy controls. The associations ... more

D. Wu; Y. Wu; J.L. Liu; B. Wang; X.D. Zhang
10/13/2011
Lung cancer risk; Meta-analysis; p21; Polymorphism; Ser31Arg

The cyclin-dependent kinase inhibitor 1A (also known as p21) is thought to be involved in tumor development by mediating cell cycle arrest through the inhibition of cyclin/CDK activity. To explore the relationship of Ser31Arg polymorphism in the p21 gene with the risk of developing lung cancer, we performed an overall and stratified meta-analysis based on ethnicity, lung ... more

G. Lin; F. Fang; X.J. Yu; L. Yu
09/21/2010
Endothelial nitric oxide synthase; Essential hypertension; Meta-analysis; Polymorphism

We examined the effect of polymorphisms in the endothelial nitric oxide synthase gene on the risk for essential hypertension in a Han Chinese population through a meta-analysis of data from 15 studies. Associations between increased risk for essential hypertension and 4b/a were obtained in a dominant model and allele contrast (aa + ab vs bb: odds ratio (OR)FE = 1.26, ... more

H.G. Wang; J.L. Wang; P. Chang; F.L. Cao; X.C. Liu; Y.B. Ma; G.X. Zhai; H.Q. Gao
12/19/2013
Cerebrovascular disease; Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism; Stroke

Several independent studies have reported the role of the methylenetetrahydrofolate reductase gene (MTHFR) A1298C polymorphism in strokes, but the results are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed in the present study. In this meta-analysis, a total of 13 studies, including 1974 cases and 2660 controls, were selected ... more

Q.Q. Lv; J. Lu; W. Wu; H. Sun; J.S. Zhang

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