Research Article

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NPP1; Ossification; Polymorphism; Posterior longitudinal ligament; Postoperative progression

Ossification of the posterior longitudinal ligament (OPLL) is a condition of the spine that can cause paralysis by compressing the spinal cord. The aim of this study was to evaluate the possible role of nucleotide pyrophosphatase phosphodiesterase 1 gene (NPP1) polymorphism in the etiology and pathology of the OPLL in Chinese patients. DNA from patients with OPLL (N = 95) and ... more

Z. He; H. Zhu; L. Ding; H. Xiao; D. Chen; F. Xue
ATP-sensitive potassium channels; Dilated cardiomyopathy; E23K; I337V; Polymorphism

ATP-sensitive potassium channels play an important role in myocardial electrical activity. Genetic disruption of these channels predisposes the myocardium to cardiac diseases. Herein we investigated whether two polymorphisms, E23K and I337V, located in the Kir6.2 subunit of ATP-sensitive potassium channels are associated with dilated cardiomyopathy (DCM) in a Chinese population. Blood was ... more

H.L. Xi; J.F. Liu; L. Li; J. Wan
Cancer; Meta-analysis; MiR-499; Polymorphism

An A/G polymorphism (rs3746444) has been identified in the miR-499 gene that can change the conformation of the secondary gene structure and thereby directly affect binding to target mRNAs and the microRNA (miRNA) maturation process, thus altering protein expression and potentially contributing to cancer susceptibility. Numerous studies investigating the associa­tion between the ... more

N. Wang; Z.Q. Tian; Y. Li; R.M. Zhou; G.Y. Wang
Coronary artery disease; Meta-analysis; Polymorphism

The G403A polymorphism in the RANTES (regulated on activation normal T cell expressed and secreted) gene has a key role in the expression of RANTES, which has been detected in a range of cells in atherosclerotic plaque. However, the association of this polymorphism with the risk of coronary artery disease (CAD) remains controversial. A meta-analysis was performed to assess the association ... more

K. Cui; X.Y. Ge; H.L. Ma
EST-SSR; Grape vine; Polymorphism; Segregation

The objectives of this investigation were to develop and validate the expressed sequence tag (EST)-simple sequence repeat (SSR) markers from large EST sequences, and to study the segregation and distribution of SSRs within two grapevine parental lines. In total, 94 F1 lines crossed between "Early Rose" and "Red Globe" were studied. Approximately 2100 EST-SSR sequences of ... more

E. Kayesh; Y.Y. Zhang; G.S. Liu; N. Bilkish; X. Sun; X.P. Leng; J.G. Fang
Epithelial ovarian cancer; Gene expression; Nuclear factor-kappa B; Polymorphism; β-transducin repeat-containing protein

Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological cancers. Nuclear factor-kappa B (NF-κB) is involved in carcinogenesis and in the development of EOC. The β-transducin repeat-containing protein (β-TrCP) is a positive regulator of the NF-κB signaling pathway. Recent studies have indicated that the -94 ins/del ATTG polymorphism in the promoter region of ... more

Z.H. Huo; H.J. Zhong; Y.S. Zhu; B. Xing; H. Tang
Genetic relationship; Lolium; Polymorphism; RAPD markers; Taxonomy

The genus Lolium is one of the most important groupings of temperate forage grasses, including about eight recognized species that are native to some temperate and subtropical regions of the northern hemisphere. We examined genetic relationships among 18 accessions representing all Lolium species using RAPD markers. Among 50 random primers that we screened, 13 gave ... more

X. Ma; X.Y. Gu; T.T. Chen; S.Y. Chen; L.K. Huang; X.Q. Zhang
Endothelial nitric oxide synthase; Intervertebral disc degeneration; Polymorphism; Vascular endothelial growth factor

Disturbances in blood flow to intervertebral discs (IVD) play an important role in IVD degeneration. Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) are extremely important angiogenic factors for vasodilation and neovascularization. We investigated the relationship between single nucleotide polymorphisms (SNPs) of the VEGF and eNOS ... more

I.B. Han; A.E. Ropper; Y.D. Teng; D.A. Shin; Y.J. Jeon; H.M. Park; D.E. Shin; Y.S. Park; K.N. Kim; N.K. Kim
Association signal; Colorectal cancer; IL6 gene; Meta-analysis; Polymorphism

Interleukin 6 (IL6) is a pleiotropic cytokine involved in physiological processes and in a variety of human malignancies. It is thus a logical candidate for being a causative factor underlying colorectal cancer (CRC). The association between the IL6 -174G>C polymorphism and CRC has been widely evaluated; yet, there is a lack of agreement between studies on the role of ... more

J.J. Hu; Z.T. Wang; J. Zhong
Polymorphism; Saudi; Tumor necrosis factor; Vitiligo

Vitiligo is an acquired depigmentary disorder of the skin, characterized by multiple susceptibility loci and genetic heterogeneity. The etiology of vitiligo is unknown but several hypotheses, including an autoimmune origin, have been proposed. Tumor necrosis factor (TNF)-α, a pleiotropic proinflammatory cytokine, has been shown to play a critical role in several autoimmune diseases ... more

F. Al-Harthi; A. Zouman; M. Arfin; M. Tariq; A. Al-Asmari