Research Article

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04/22/2015
Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism; Psoriasis

Previous studies investigating the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms and psoriasis risk have reported inconsistent results. The present meta-analysis aimed to comprehensively evaluate the association between MTHFR 677C/T polymorphism and psoriasis risk. The studies regarding the association between MTHFR 677C/T ... more

J.H. Qi; N. Shi; Y.J. Chen; G. Nie
04/17/2015
Angiotensin-converting enzyme; Meta-analysis; Polymorphism; Sarcoidosis

Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence ... more

R. Zhu; L.Q. Bi; H. Kong; S.L. Tilley; H. Wang; W.P. Xie
04/15/2015
Colorectal cancer; IGFBP-3; Meta-analysis; Meta-regression; Polymorphism

Recent evidence suggests that genetic variations in the IGFBP-3 gene may impact susceptibility to colorectal cancer, but individually published results are inconclusive. Our meta-analysis was aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 1, 2013. This meta-analysis was ... more

J. Xu; L. Xu; L.T. Li; Q. You; L.S. Cha
04/10/2015
Coronary artery disease; Interleukin-6; Polymorphism

We conducted a case-control study to investigate the association between IL-6 -174 G>C and -572 C>G polymorphisms and the risk of coronary artery disease (CAD). We genotyped IL-6 ˗174 G>C and -572 C>G in 402 patients with CAD and 402 control individuals. IL-6 -174 G>C (rs1800795) and -572 C>G (rs1800796) alleles were detected by polymerase chain ... more

K. Wang; P.S. Dong; H.F. Zhang; Z.J. Li; X.M. Yang; H. Liu
04/10/2015
Hanwoo cattle; IGF1 concentration; Polymorphism

In this study, we investigated the associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle. Polymerase chain reaction primers were based on GenBank accession No. AF404761 and amplified approximately 533-bp segments. Newly identified sequences were submitted to GenBank ... more

H.Y. Chung; Y.J. Choi; H.N. Park; M.E. Davis
03/31/2015
Asthma; Meta-analysis; Polymorphism; Single nucleotide polymorphism

The IL-4R Q576R polymorphism has been reported to increase susceptibility to asthma, but the results are controversial. Thus, we performed a meta-analysis to evaluate the association of the IL-4R Q576R polymorphism and asthma risk in the Chinese Han population. A total of sixteen eligible case-control studies that evaluated the relationship between the IL-4R ... more

Z.Y. Huang; B.J. Cheng; G.J. Cai; B.F. Zhang
03/31/2015
ERCC1; ERCC2; Glioma; Polymorphism

Several studies have examined the association between excision repair cross-complementation group 1 (ERCC1) C8092A and ERCC2 Lys751Gln polymorphisms and glioma risk, but the results have been inconclusive. We conducted a meta-analysis of 12 studies to determine the association between ERCC1 rs3212986 and ERCC2 rs13181 genes and glioma susceptibility. We searched for relevant studies in ... more

C.X. Zhou; J.H. Zhao
03/30/2015
Cardiovascular events; Hemodialysis; IL-6; Polymorphism

We aimed to investigate the role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis. Blood samples were collected from 216 patients receiving hemodialysis treatment. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype IL-6 -634C/G, -174G/C and -572C/G. By ... more

Y. Song; H.D. Gu; Y. He; J.W. Wang
03/30/2015
Fatty acid synthase gene; Meat quality traits; Polymorphism; Yak

Fatty acid synthase (FASN) is a key enzyme in fatty acid anabolism that plays an important role in the fat deposit of eukaryotic cells. Therefore, in this study, we detected 2 novel single-nucleotide polymorphisms (SNPs) in the FASN gene in 313 adult individuals of Datong yak using polymerase chain reaction-single strand conformation polymorphism and DNA sequencing techniques. SNP ... more

M. Chu; X.Y. Wu; X. Guo; J. Pei; F. Jiao; H.T. Fang; C.N. Liang; X.Z. Ding; P.J. Bao; P. Yan
03/30/2015
Ischemic stroke; miR-149; Polymorphism

Clinical and experimental data have demonstrated that genetic factors play an important role in determining the susceptibility to ischemic stroke (IS). The present study was performed to clarify the association between the pre-microRNA-149 (miR-149) single nucleotide polymorphism rs71428439 and the risk of IS in the Jiangsu Han population. Polymerase chain reaction and restriction ... more

Q.Y. Chen; N. Liu; J. Ma; Y. Fang; Y. Cao; H. Li; Y.C. Liu

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