Research Article

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06/12/2015
Apelin; Chinese; Hpertension; Losartan; Polymorphism

We determined whether the blood pressure response to losartan in an older Chinese population with essential hypertension was associated with apelin gene polymorphisms. We genotyped the -1860T>C polymorphism of the apelin gene in a case-control study of 222 patients with hypertension and 250 controls. Following 24 weeks of treatment with losartan (50 mg/day), reductions in systolic ... more

J. Jia; C. Men; K.T. Tang; Y.Y. Zhan
06/11/2015
Coronary heart disease; Meta-analysis; Polymorphism; PPARD; rs2016520

PPARD encodes peroxisome proliferator-activated re­ceptor delta, which has been shown to play an important role in control­ling lipid metabolism and atherosclerosis. In this case-control study, we explored the relationship between PPARD rs2016520 polymorphism and coronary heart disease (CHD) in a Han Chinese population. A to­tal of 657 CHD cases and 640 controls were included in the ... more

H.D. Ye; Y.R. Li; Q.X. Hong; A.N. Zhou; Q.L. Zhao; L.M. Xu; M.Q. Xu; X.T. Xu; L.L. Tang; D.J. Dai; D.J. Jiang; Y. Huang; D.W. Wang; S.W. Duan
06/11/2015
Breast cancer; MicroRNA; Polymorphism

Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide polymorphisms (mir-499 rs3746444 A> ... more

P. Qi; L. Wang; B. Zhou; W.J. Yao; S. Xu; Y. Zhou; Z.B. Xie
06/11/2015
Microsatellite; Odontobutis potamophila; Polymorphism

We characterized 16 novel polymorphic loci isolated from a partial genomic DNA library of Odontobutis potamophila enriched for CA repeats. We tested the variability of these microsatellites on 51 unrelated individuals collected in China. All loci were polymorphic. The average allele number was 14.6 per locus, ranging from 2 to 27. The observed heterozygosity ranged from 0.35 to ... more

Y.B. Shen; D. Li; J.L. Li; R.Q. Wang; Y.F. Xuan
06/01/2015
Arg389Gly; Gene; Heart failure; Meta-analysis; Polymorphism; β1 adrenergic receptor

Numerous studies have evaluated the association between Arg389Gly polymorphism in the β1 adrenergic receptor gene and heart failure risk. However, the specific association is still controversial. We performed a meta-analysis of all case-control studies that evaluated the association between Arg389Gly polymorphism and heart failure in humans. Studies were identified in the PubMed, Embase, ... more

S.T. Ma; W. Zhao; B. Liu; R.Y. Jia; C.J. Zhao; L.Q. Cui
06/11/2015
GSTT1; Neoplasia; Polymorphism; Pterygium

Pterygium is an inflammatory and degenerative ocular surface disease in which the conjunctiva on the cornea grows to form a fibrous tissue in the shape of a triangle. The disorder may be characterized by cell proliferation, inflammatory processes, fibrosis, angiogenesis, and destruction of the extracellular matrix. The anomaly is considered a degenerative eye disease and is erroneously ... more

G.Mdos Reis; deP.R. Júnior; K.S.Fe Silva; D.A. Rodrigues; M.C.S. Gomes; J.V.M. Martins; I.R. da Costa; G.A. Freitas; K.K.O. Moura
06/11/2015
GST; GSTM1; Polymorphism; Pterygium

The first reports about pterygium date back to Hip­pocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascular­ized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea. Many physical and biological factors are associated with the pathogenesis of pterygium ... more

deP.R. Júnior; G.Mdos Reis; K.S.Fe Silva; D.A. Rodrigues; M.C.S. Gomes; J.V.M. Martins; I.R. da Costa; G.A. Freitas; K.K.V.O. Moura
06/01/2015
Chinese bayberry; EST-SSR; Myrica rubra; Polymorphism; RNA-seq

Most plant expressed sequence tag-simple sequence repeats (EST-SSRs) are not polymorphic, and it is important to learn the characteristics of highly polymorphic EST-SSRs. In this study, 357 compound and 5557 non-compound EST-SSRs, identified from the transcriptome of the Chinese bayberry (Myrica rubra ‘Biqi’), were divided into 11 types based on their characteristics. ... more

S.Y. Zhang; C. Feng; C.J. Xu; C.Q. Zhu; K.S. Chen
05/29/2015
Cross-amplification; Microsatellite markers; Paramisgurnus dabryanus; Polymorphism

The large-scale loach, Paramisgurnus dabryanus, is a small freshwater fish of major economic importance in many Asian countries, particularly China and South Korea. Fifteen polymorphic microsatellite (simple sequence repeat) markers were obtained through cross-species amplification between this loach and a related species, Misgurnus anguillicaudatus (GenBank accession numbers: KC117456 to ... more

G. Chen; S. Huang; J. Gao; X. Bai; W. Wang; X. Cao
05/25/2015
Arctic fox; Leptin gene; Leptin receptor gene; Polymorphism; Production performance

The polymerase chain reaction-single-strand conforma­tion polymorphism technique was employed to measure mononucleo­tide diversity in the coding region of the leptin and leptin receptor genes in the Arctic fox. The relationships between specific genetic mutations and reproductive performance in Arctic foxes were determined to im­prove breeding strategies. We found that a leptin gene ... more

M. Zhang; X.J. Bai

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