Research Article

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Diffuse gastric cancer; Epithelial cadherin; Genetic susceptibility; Meta-analysis; Polymorphism

Several previous studies have investigated whether the -160C/A epithelial cadherin promoter polymorphism confers an increased risk of diffuse gastric cancer (DGC), but conflicting results have been reported. To explore further the association of this polymorphism with DGC susceptibility, we performed an extensive search of relevant studies and conducted a meta-analysis to obtain a more ... more

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EPHX1; Esophageal cancer; Meta-analysis; Polymorphism

Microsomal epoxide hydrolase 1 (EPHX1) is an important biological phase II metabolic enzyme that is extensively involved in the metabolism of diverse environmental carcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Many articles have reported the association between EPHX1 (Tyr113His and His139Arg) polymorphisms and esophageal cancer risk, but the results are ... more

X. Tan; W.W. He; Y.Y. Wang; L.J. Shi; M.W. Chen
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COX-1; Gene; Polymorphism

Variation in the gene encoding cyclooxygenase-1 (COX-1) is involved in the process of aspirin resistance. This study investigated the genetic variations in the COX-1 gene. The 4 coding regions of the human COX-1 gene in 90 pediatric patients (median age of 6.5 months, 55% males) with cardiovascular anomalies were screened using DNA sequencing. Twenty coding-region variants causing amino ... more

I. Coskun; Y. Colkesen; F. Ayik; A. Berdeli; Y. Atay
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Cancer; Disparities; IL-6; Polymorphism; Prostate

Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation could be linked to genetic factors, including genetic polymorphism ... more

S. Mandal; F. Abebe; J. Chaudhary
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Asthma; Meta-analysis; ORMDL3; Polymorphism; rs7216389

While increasing scientific evidence suggests that the ORMDL3 rs7216389 polymorphism may contribute to a higher susceptibility to asthma, many of the current studies have yielded inconclusive results. This meta-analysis aimed to assess the association between the ORMDL3 rs7216389 polymorphism and the risk of asthma. An extensive literature search for relevant studies was ... more

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Gastric cancer; IL-17A; IL-17F; Polymorphism

We conducted a meta-analysis of eligible studies to estimate the association between gastric cancer risk and rs2275913G>A IL-17A and rs763780T>C IL-17F polymorphisms. We searched the relevant studies in both Chinese and English through PubMed, the Web of Science, the Cochrane Library, and EMBASE up to January 1, 2014, including 3939 cases and 5407 controls. Seven eligible case- ... more

Z. Li; Y. Liu; D. Cao; M. Jiang; F. Luo
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Cytokine gene; IL-10; IL-1β; IL-8; Invasive Candida infection; Polymorphism

The aim of this study was to investigate the role of cytokine genes in the susceptibility to Candida infection. A total of 275 consecutive patients diagnosed with Candida infection were selected between May 2010 and May 2011, along with 305 uninfected controls. Genotyping of the IL-1β gene polymorphisms (IL1β) rs1143634, IL1βrs16944 ... more

R.T. Sun; W.J. Tian; X.W. Xing; S.H. Gao; S.B. Wang
06/18/2015
Interleukin gene; Polymorphism; Recurrent oral ulceration

We conducted a case-control study to investigate the association between the functional IL-1β+3954 (C/T), IL-6-174 (G/C), IL-10-1082 (G/A), and IL-10-819C/T genetic polymorphisms and risk of recurrent oral ulceration (ROU) in a Chinese population. Polymorphisms of IL-1β+3954C/T, IL-6-174G/C, IL-10-1082A/G and IL-10-819C/T were assessed by polymerase chain reaction-restriction fragment ... more

C. Jing; J.Q. Zhang
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Alzheimer’s disease; Apolipoprotein E; Meta-analysis; Polymorphism; PPARγ

We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferator-activated receptor gamma (PPARγ) gene are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between the PPARγ Pro12Ala and His447His polymorphisms and AD in subjects. The meta-analysis was performed according to the ... more

Y.H. Lee; G.G. Song
06/18/2015
Acute pancreatitis; Inflammatory cytokines; Polymorphism

We assessed the possible correlation between genetic polymorphisms in interleukin (IL)-1β, IL-8, and IL-10 and risk of acute pancreatitis. Polymorphisms of IL-1β+3954C/T (rs1143634), IL-1β-511C/T (rs16944), IL-8 -251T/A (rs4073), IL-10 -1082A/G (rs1800896), and IL-10 -819C/T ( ... more

D. Li; J. Li; L. Wang; Q. Zhang

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