Research Article

Related GMR Articles

04/25/2013
ACE gene; Chronic obstructive pulmonary disease; Polymorphism

An insertion/deletion (I/D) polymorphism was identified in intron 16 of the gene encoding the human angiotensin I-converting enzyme (ACE), a candidate gene for chronic obstructive pulmonary disease (COPD). We investigated the relationship between this polymorphism in the ACE gene and the risk of developing COPD. Sixty-six COPD in-patients and 40 non-smoking control individuals ... more

S. Simsek; S. Tekes; D. Oral; A. Turkyılmaz; B. Isik; M.R. Isik; H. Akkoc
04/02/2013
Cattle; Gene; mutations; Polymorphism; Sequence; TNF-RII

Tumor necrosis factor receptor type II (TNF-RII) is a surface glycoprotein that can form a complex with TNF-α and participate in the body's immune response. Functions of TNF-RII are impaired in the pathogenesis of viral diseases. We analyzed sequences in the regulatory region of the TNF-RII gene in cattle. An attempt was also made to identify mutations that would have the greatest effect ... more

A. Stachura; E. Kaczmarczyk; B. Bojarojć-Nosowicz
04/02/2013
Goat; Growth traits; Myostatin gene (MSTN); PCR-SSCP; Polymorphism

Mutations in the myostatin (MSTN) gene can inactivate its expression and result in a non-functional protein, which leads to dramatic muscularity and a “double-muscling” phenomenon in many species. Using gene sequencing and polymerase chain reaction-single-strand conformation polymorphism methods, polymorphisms of the MSTN gene were investigated as a candidate marker for ... more

Z.J. Zhang; Y.H. Ling; L.J. Wang; Y.F. Hang; X.F. Guo; Y.H. Zhang; J.P. Ding; X.R. Zhang
03/13/2013
Cattle; Hanwoo; Phospholipid transfer protein; Polymorphism; SNP

Phospholipid transfer protein (PLTP) regulates high-density lipoprotein metabolism. The gene encoding PLTP is located on bovine chromosome 13. The objective of this study was to identify single nucleotide polymorphisms (SNPs) in the Hanwoo (Bos taurus coreanae) PLTP gene to detect novel mutations affecting economically important traits. Five SNPs were identified in the coding ... more

J. Seong; J.D. Oh; H.K. Lee; G.J. Jeon; H.S. Kong
03/15/2013
IL-18; Polymorphism; Prostate cancer

Interleukin-18 (IL-18) has been implicated in a wide variety of cellular functions that affect the biological response to tumors. However, there is insufficient evidence to prove that IL-18 gene variants are associated with risk of prostate cancer. We examined a possible association between two promoter polymorphisms, -137G/C (rs187238) and -607C/A (rs1946518), in the IL-18 ... more

J.M. Liu; J.N. Liu; M.T. Wei; Y.Z. He; Y. Zhou; X.B. Song; B.W. Ying; J. Huang
02/27/2013
Chicken; Cloning; Expression; Nramp1 gene; Nramp2 gene; Polymorphism

Natural resistance-associated macrophage protein 1 and 2 encoding genes (Nramp1 and Nramp2) are related to many diseases. We cloned the cDNA of chicken Nramp1 and Nramp2 genes, characterized their expression and polymorphisms, and investigated the association of some SNPs with resistance to salmonellosis. The Nramp1 cDNA was 1746 bp long and the ... more

X.M. He; M.X. Fang; Z.T. Zhang; Y.S. Hu; X.Z. Jia; D.L. He; S.D. Liang; Q.H. Nie; X.Q. Zhang
02/08/2013
IRAP; ISSR; Mating-type; Musa sp; Polymorphism

The fungus Mycosphaerella fijiensis is the causative agent of black sigatoka, which is one of the most destructive diseases of banana plants. Infection with this pathogen results in underdeveloped fruit, with no commercial value. We analyzed the distribution of the M. fijiensis mating-type system and its genetic variability using M13 phage DNA markers. We found a 1:1 ... more

C.B. Queiroz; E.C. Miranda; R.E. Hanada; N.R. Sousa; L. Gasparotto; M.A. Soares; G.F. Silva
01/24/2013
P2X7; Polymorphism; Tuberculosis

Susceptibility to tuberculosis may be influenced by variations in human genes. The P2X7 receptor is an ATP-gated cation channel expressed in immune cells, and it influences the release of proinflammatory cytokines from monocytes and macrophages. In the present study, we aimed to evaluate the impact of P2X7 gene rs2393799 (-762T/C) and rs1718119 (Thr348Ala) polymorphisms ... more

G. Bahari; M. Hashemi; M. Taheri; M. Naderi; A. Moazeni-Roodi; H.R. Kouhpayeh; E. Eskandari-Nasab
02/07/2013
Polymorphism; Rheumatoid arthritis; Toll-like receptor

We investigated whether Toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis and whether they influence clinical characteristics of rheumatoid arthritis. Studies were considered relevant for our meta-analysis if at least two comparisons of an issue were available. Eleven studies with 2078 patients with rheumatoid arthritis and 2581 controls were ... more

Y.H. Lee; S.C. Bae; G.G. Song
12/17/2012
Early growth traits; Hu sheep; MC4R gene; Polymorphism

The melanocortin-4 receptor (MC4R) has important roles in regulating food intake, energy balance, and body weight in mammals. In pigs and cattle, MC4R mutations have been identified as genetic markers for growth and traits. Compared with abundant research conducted on other livestock species, little is known about mutations of the ovine MC4R gene. We investigated the ... more

X.M. Song; J.F. Jiang; G.Z. Zhang; F.X. Shi; Y.Q. Jiang

Pages