Research Article

Related GMR Articles

04/06/2010
DNA repair; Endometriosis; Polymorphism; XRCC3 Thr/Thr

Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. We investigated the association of polymorphisms in the DNA repair genes XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys with endometriosis risk. Genotypes were determined by PCR-RFLP assays in 52 patients with endometriosis and 101 age- ... more

R. Attar; C. Cacina; S. Sozen; E. Attar; B. Agachan
04/02/2013
Endometriosis; Meta-analysis; Polymorphism; VEGF

Endometriosis is a chronic gynecological disease defined as the presence of the endometrium outside the uterine cavity. Endometriosis is a multifactorial and polygenic disease in which angiogenesis may be implicated. Angiogenesis is under the control of numerous inducers, including vascular endothelial growth factor (VEGF). Many studies have reported that VEGF plays a role in the ... more

Y.Z. Li; L.J. Wang; X. Li; S.L. Li; J.L. Wang; Z.H. Wu; L. Gong; X.D. Zhang
05/15/2012
Codon 72; Endometriosis; Mexican population; Polymorphism; TP53 gene

The TP53 tumor suppressor gene plays an important role in cell cycle regulation; polymorphisms of this gene have been associated with endometriosis. We examined the role of TP53 codon 72 polymorphism by comparing genotypes of 235 healthy Mexican women (controls with surgically excluded endometriosis) with the genotypes of 151 Mexican women with endometriosis. The observed genotype ... more

M.P. Gallegos-Arreola; L.E. Figuera-Villanueva; A.M. Puebla-Pérez; H. Montoya-Fuentes; A.E. Suarez-Rincon; G.M. Zúñiga-González
08/02/2013
Endometriosis; GSTM1; GSTT1; Infertility

Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyzed the frequency of ... more

A.B. Frare; A.M. Barbosa; I.R. Costa; S.R. Souza; R.C.P.C. Silva; B.M. Bordin; C.L.Ribeiro Júnior; K.K.V.O. Moura
08/26/2014
Cell cycle; Endometriosis; Gene polymorphism; p53; TP53

We evaluated the association between TP53 gene polymorphisms and endometriosis in Brazilian women. Genomic DNA was extracted from swabs of buccal cells collected from hospital patients. TP53 gene polymorphisms were investigated at three codons: TP53*11 Glu/Gln or Lys (GAG->CAG or AAG), TP53*72 Arg/Pro (CCG->CCC), and TP53*248 Arg/Thr (CGG ... more

C.M. Camargo-Kosugi; P. D’Amora; J.P.F.O. Kleine; C.V. Carvalho; H. Sato; E. Schor; I.D.C.G. Silva
09/18/2002
Brazil; Glutathione S-transferase; Polymorphism

The glutathione S-transferase (GST) family of enzymes has a vital role in phase II of biotransformation of environmental carcinogens, pollutants, drugs and other xenobiotics. GSTs are polymorphic, with the type and frequency of polymorphism being ethnic dependent. Polymorphisms in GST genes have been shown to be associated with susceptibility to disease and disease outcome. We ... more

A. Rossini; D.C.M. Rapozo; L.M.F. Amorim; J.M.B. Macedo; R. Medina; J.F.N. Neto; C.V.M. Gallo; L.F.R. Pinto
03/28/2007
Dog breeds; Growth; Polymorphism; SNP; SOCS2

Suppressor of cytokine signaling 2 (SOCS2) is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. In an effort to identify polymorphisms in the SOCS2 gene that may be associated with body size in dogs, we characterized the canine SOCS2 gene and analyzed its genetic diversity among small and large dog breeds ... more

G. Rincón; A.E. Young; D.L. Bannasch; J.F. Medrano
03/14/2006
Alu; CEPH panel; Human population genetics; Polymorphism; X chromosome

We describe a novel polymorphic Alu insertion (DXS225) on the human X chromosome (Xq21.3) embedded into an L1 retrotransposon. The DXS225 polymorphism was genotyped in 684 males from the CEPH Human Genome Diversity Panel. This insertion was found in all regions of the globe, suggesting that it took place before modern humans spread from Africa ca. 100,000 ... more

R.Wellerson Pereira; S.Silva dos Santos; S.Danilo Jun Pena
01/05/2009
meningiomas; metastases; Methylation; Polymorphism; schwannomas; TP53

The p53 tumor suppressor gene is the most frequently mutated gene in human cancer; this gene is mutated in up to 50% of human tumors. It has a critical role in the cell cycle, apoptosis and cell senescence, and it participates in many crucial physiological and pathological processes. Polymorphisms of p53 have been suggested to be associated with genetically determined susceptibility in various ... more

L.O. Almeida; A.C. Custódio; G.R. Pinto; M.J. Santos; J.R.W. Almeida; C.A. Clara; J.A. Rey; C. Casartelli
02/17/2009
Bombyx mori multiple nucleopolyhedrovirus; Molecular markers; Polymorphism; Random amplified polymorphic DNA; Silkworm

The silkworm Bombyx mori L. is particularly susceptible to virus diseases, especially B. mori nucleopolyhedrovirus (BmNPV). Disease resistance, along with high productivity, are important selection criteria for developing commercial hybrids of B. mori. We used bioassays and molecular markers linked to susceptibility/resistance to baculovirus infection to analyze the ... more

L.F.C. Ribeiro; D.B. Zanatta; J.P. Bravo; R.M.C. Brancalhão; M.A. Fernandez

Pages