Research Article

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10/15/2013
EPHX1 gene; Esophageal cancer; Meta-analysis; Polymorphism

Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the results have been contradictory. We investigated the association of EPHX1 Tyr113His and ... more

J.J. Hu; Z.T. Wang; B. Li
10/17/2013
Esophageal cancer; Flow cytometry; Gene transfection; MT-1E; MT-3; Proliferation

Metallothionein (MT)-3 has cell growth inhibitory activity, and is the only currently known MT subtype with unique physiological functions. The expression levels of MT-1E, a subtype of MT-1, were positively correlated with the degree of esophageal cancer malignancy. The present study aimed to investigate the effects of MT-3 and MT-1E gene transfection on the proliferation, cell cycle, and ... more

Z.Q. Tian; Y.Z. Xu; Y.F. Zhang; G.F. Ma; M. He; G.Y. Wang
01/16/2013
Esophageal cancer; Gene polymorphism; Meta-analysis; X-ray cross-complementing gene 1

We made a meta-analysis of the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and esophageal cancer (EC) risk. Statistical analysis was performed with the Review Manager version 4.2.8 software program and STATA version 11.0. We selected 16 case-control studies for this meta-analysis, including 3591 EC cases and 5752 controls. Overall, the ... more

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07/25/2014
Esophageal cancer; MicroRNA-197; Prognosis

The aim of this study was to investigate the significance of the microRNA miR-197 expression level in relation to clinicopathological factors and prognoses of esophageal cancer (EC). MicroRNA was extracted using the Taqman® MicroRNA Assay from 46 EC patients at the same tumor node metastasis (TNM) stage, but with different prognoses, who underwent surgery. Paracancerous normal ... more

T.Y. Wang; S.G. Liu; B.S. Zhao; B. Qi; X.G. Qin; W.J. Yao
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Esophageal cancer; Insulin-like growth factor; Lung cancer; Meta-analysis; Polymorphism

Recent evidence suggests that genetic variations in the insulin-like growth factor (IGF)-IGF receptor (IGFR)-IGF binding proteins (IGFBP) axis may impact an individual’s susceptibility to lung and esophageal cancer, but individually published results are inconclusive. Our meta-analysis aimed at providing a more precise estimation of these associations. An extensive literature search was ... more

X.P. Huang; W.H. Zhou; Y.F. Zhang
01/28/2014
EPHX1; Esophageal cancer; Meta-analysis; Polymorphism

Microsomal epoxide hydrolase 1 (EPHX1) is an important biological phase II metabolic enzyme that is extensively involved in the metabolism of diverse environmental carcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Many articles have reported the association between EPHX1 (Tyr113His and His139Arg) polymorphisms and esophageal cancer risk, but the results are ... more

X. Tan; W.W. He; Y.Y. Wang; L.J. Shi; M.W. Chen
06/12/2015
Esophageal cancer; Meta-analysis; miR-21; Prognosis

The present study aimed to explore the relationship between miRNA expression and survival in patients with esophageal cancer (EC) using meta-analysis. We searched PubMed, EMBASE, CNKI, Wanfang, and ISI Web of Science databases without time restrictions, and extracted relevant data, such as the name of first author, publication year, age, gender, number of case, etc. from the studies ... more

S.W. Wen; Y.F. Zhang; Y. Li; Z.X. Liu; H.L. Lv; Z.H. Li; Y.Z. Xu; Y.G. Zhu; Z.Q. Tian
03/30/2015
Collateral circulation; Esophageal cancer; Nutrition; Plasma lipid; Thoracic duct

The aim of this study was to determine the influence of thoracic duct ligation on the lipid metabolism of patients with esophageal carcinoma after esophagectomy. A total of 74 patients with esophageal carcinoma who underwent esophagectomy were divided into 2 groups according to whether or not their thoracic duct was ligated. Thirty-nine patients were in the thoracic duct ligation group ... more

J.P. Liu; Y.H. Zhang; B. Yang; Q. Chen; L. Cao
04/26/2013
CCND1 gene; Esophageal cancer; Genetic association; Meta-analysis; Polymorphism

The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the allelic/genotypic ... more

W. Cai; Z.T. Wang; J. Zhong; Y. Zhang
07/24/2014
Biomarkers; Curative effect; Esophageal cancer; National difference

This study aimed to explore some useful biomarkers to focus on the diagnosis and therapy response judgment in esophageal squamous cell carcinoma in Xinjiang. We used enzyme-linked immunosorbent method and immunohistochemistry to detect the expression of VEGF, EGFR, ES, HER-2, and NF-κBp in the serum and tissue with esophageal squamous cell carcinoma, and to analyze the relationship ... more

L. Zhang; J. Sun; J.Q. Zhang; M. Yang; G. Bai; X.L. Ma

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