Research Article

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02/28/2014
Asthma; IL-4; Meta-analysis; Polymorphisms; Promoter

This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that the polymorphisms IL-4 C-33T and C-589T were significantly ... more

L. Tang; H.G. Lin; B.F. Chen
01/08/2014
Gene polymorphism; Head and neck carcinomas; Meta-analysis; p53 codon 72

Genetic factors have been shown to play a role in the development of head and neck cancers (HNCs). However, studies investigating the association between the TP53 Arg72Pro polymorphism and HNCs susceptibility have yielded conflicting results. Hence, we performed a meta-analysis of all eligible studies (up to January 1, 2012) to derive a more precise estimation of this association ... more

W.H. Ren; D.K. Jiang; Y. Pei; S.Q. Wang; X.M. Yang; L. Yu
06/12/2015
Esophageal cancer; Meta-analysis; miR-21; Prognosis

The present study aimed to explore the relationship between miRNA expression and survival in patients with esophageal cancer (EC) using meta-analysis. We searched PubMed, EMBASE, CNKI, Wanfang, and ISI Web of Science databases without time restrictions, and extracted relevant data, such as the name of first author, publication year, age, gender, number of case, etc. from the studies ... more

S.W. Wen; Y.F. Zhang; Y. Li; Z.X. Liu; H.L. Lv; Z.H. Li; Y.Z. Xu; Y.G. Zhu; Z.Q. Tian
05/25/2015
Meta-analysis; Monocyte chemoattractant protein-1; Tuberculosis

Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and the risk of tuberculosis (TB). However, the results have been inconsistent and inconclusive. In this study, we performed a meta-analysis to evaluate the association between the MCP-1 -2518A/G polymorphism and TB. The ... more

G. Tian; X. Li; H. Li; X. Wang; B. Cheng
05/18/2015
Ankylosing spondylitis; Gene expression; Meta-analysis; Pathway analysis

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Y.H. Lee; G.G. Song
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Angiotensinogen; Gene polymorphism; Meta-analysis; Myocardial infarction

Numerous studies have evaluated the association between the T174M polymorphism in the angiotensinogen (AGT) gene and myocardial infarction (MI) risk. However, the specific association remains controversial because of small sample sizes and varied study designs among different studies. We performed a meta-analysis to assess this correlation. A comprehensive search was conducted to ... more

P.Y. Hu; Y.W. Wang; X.H. Pang; H.W. Wang
03/27/2015
Autism; Differentially expressed genes; Expression data; Meta-analysis; Microarray

The purpose of this study was to identify differentially expressed (DE) genes and biological processes associated with changes in gene expression in autism. We performed a meta-analysis using new publicly available Gene Expression Omnibus (GEO) datasets of autism. We performed Gene Ontology (GO) enrichment analyses and pathway analysis using the Kyoto Encyclopedia of Genes and Genomes ( ... more

L.F. Ning; Y.Q. Yu; E.T. GuoJi; C.G. Kou; Y.H. Wu; J.P. Shi; L.Z. Ai; Q. Yu
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C-erbB-2; Gastric cancer; Meta-analysis; Prognosis

The prognostic role of c-erbB-2 in gastric cancer is controversial. We conducted a meta-analysis to evaluate the relationship between c-erbB-2 expression and the prognosis of gastric cancer. We evaluated 20 published studies assessing the relationship between c-erbB-2 and gastric cancer prognosis. The Revman 5.0 software was used to perform literature retrieval, article selection, data ... more

Z.Q. Wang; B.J. Sun
02/06/2015
FABP2; Meta-analysis; Metabolic syndrome; Obesity; Type 2 diabetes mellitus

Previous studies have reported associations between the functional FABP2 Ala54Thr (rs1799883) polymorphism and type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome in different populations with conflicting results. We investigated the association between the FABP2 Ala54Thr polymorphism and T2DM (235 cases, 431 controls), obesity (377 cases, 431 controls), and ... more

Y. Liu; G. Wu; L. Han; K. Zhao; Y. Qu; A. Xu; Q. Huang
10/30/2013
Aging; Atrial fibrillation; Growth-associated protein (GAP43); Han nationality; Tyrosine hydroxylase; Xinjiang Uygur

The aim of this study was to explore the changes in gene and protein expressions of tyrosine hydroxylase (TH) and growth-associated protein 43 (GAP43) in aging atrial fibrillation patients of Xinjiang Uygur and Han nationality, and the significance of the changes. Real-time polymerase chain reaction and Western blot analysis were used to detect gene and protein expressions of TH and GAP43 ... more

Y.D. Li; J.X. Li; B.P. Tang; T.Y. Gan; G.J. Xu; X.H. Zhou; H. Li; X. Guo; A. Mahemuti; Q. Sun; Y.Y. Zhang; J. Wang

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