Research Article

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ADRB2 gene polymorphisms; Body mass index; Obesity; Obstructive sleep apnea syndrome; Restriction fragment length polymorphism; Turkish population

We determined the distribution of the Arg16Gly and Gln27Glu polymorphisms of the beta-2 adrenergic receptor gene (ADRB2) in patients with obstructive sleep apnea syndrome as well as a control group in Northeastern Turkey. A total of 52 patients diagnosed with obstructive sleep apnea in a sleep laboratory and 78 control subjects were examined. Peripheral blood samples were taken ... more

İ. Gök; İ. Çelebi; N. Hüseyinoğlu; C. Özic
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Leptin; obese gene; Polymerase chain reaction; Quantitative trait loci; Restriction fragment length polymorphism

The aim of the present study was to identify polymorphisms in the leptin gene of 112 pigs and compare the maternal and paternal lineage of Pietrain and Large White breeds that underwent a divergent selection for over 30 years. DNA samples extracted from the blood of these animals were amplified by polymerase chain reaction and genotyped by restriction fragment length polymorphism ... more

A.C.P. Silveira; R.C. Antunes; J.F. Almeida; T.F. Braga; P.F.A. Freitas; A.S.M. César; A.S.M. César; E.C. Guimarães
03/11/2008
composite heifers; Follicle-stimulating hormone receptor; Luteinizing hormone receptor; Restriction fragment length polymorphism; Sexual precocity

The purpose of the present research was to investigate the effects of polymorphisms of luteinizing hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR) genes, evaluated by polymerase chain reaction-restriction fragment length polymorphism in European-Zebu composite beef heifers from six different breed compositions. The polymorphism site analysis from digestion with Hha ... more

E.P. Marson; J.B.S. Ferraz; F.V. Meirelles; J.C.C. Balieiro; J.P. Eler
08/26/2011
Cathechol-o-methyltransferase; Dopamine D3 receptor; Polymerase chain reaction; Restriction fragment length polymorphism; Schizophrenia; Single nucleotide polymorphism

Molecular components of the dopamine D3 receptor (DRD3) may play an important role in the pathophysiology of schizophrenia. Previous studies have demonstrated an association between DRD3 Ser9Gly and cathechol-o-methyltransferase (COMT, SNP = rs165656) polymorphisms and schizophrenia but the results were inconclusive. We investigated this apparent association between Ser9Gly (A/G) ... more

S.F. Tee; P.Y. Tang; H.C. Loh
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BDNF; DARPP; Restriction fragment length polymorphism; Schizophrenia; SNP

A number of studies have pointed to the association of BDNF (brain-derived neurotrophic factor) and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) with schizophrenia. The purpose of this study was to determine whether these two genes are involved in the pathogenesis of schizophrenia in the Malay population. Two single nucleotide polymorphisms Val66Met of ... more

H.C. Loh; P.Y. Tang; S.F. Tee; T.J. Chow; Y.C. Cheah; S.S.J. Singh
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CYP1A1; CYP1A1m1; Glaucoma; Polymorphism; Primary open-angle glaucoma; Restriction fragment length polymorphism

The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage. The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I. As a result, this polymorphism has been related to several diseases that are influenced by ... more

N.B. Costa; C.T.X. Silva; A.B. Frare; R.E. Silva; K.K.V.O. Moura
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FGD1; Intellectual developmental disorders; Restriction fragment length polymorphism; Single nucleotide polymorphism; Single-strand conformation polymorphism

FGD1 encoding a guanine nucleotide exchange factor, specifically activates Rho GTPase cell division cycle 42 (Cdc42). Dysfunction of FGD1 causes Aarskog-Scott syndrome (MIM #305400), an X-linked disorder that may affect bone and intellectual development. However, the relationship between FGD1 and intellectual developmental disorders (IDD) remains unclear. The purpose of this study was to ... more

J.L. Li; Y.J. Li; K.J. Zhang; L. Lan; J.G. Shi; X. Yang; M.J. Zhang; F.C. Zhang; X.C. Gao
08/15/2014
Epilepsy; Retention rates; Sodium valproate

This study aimed to investigate the prevalence and treatment gaps of epilepsy, as well as the clinical effects, drug safety, and retention rates of sodium valproate (VPA) for treating epilepsy. Physicians received supervised training to use the survey form recommended by the Chinese Association Against Epilepsy while screening for suspected or confirmed epilepsy cases. These cases were ... more

D.H. Huang; J.O. Zheng; J. Chen; L. Yu
10/28/2008
C1236T; MDR1; Polymorphism; Turkish population

Human P-glycoprotein (P-gp) is encoded by the MDR1 gene, which is located on chromosomal region 7q21 and consists of 28 exons. To date, over 50 single nucleotide polymorphisms (SNPs) have been reported for the MDR1 gene. The effect of these polymorphisms on P-gp function or their clinical impact is in most cases unknown, but some of the SNPs are known to be of functional ... more

G. Gümüş-Akay; A.R. üstemoğlu; A. Karadağ; A. Sunguroĝlu; A. Sunguroĝlu
12/12/2014
Angiotensin converting enzyme; Chronic obstructive pulmonary disease; Renin angiotensin system; Turkish population

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow obstruction that occurs as a result of the normal inflammatory process to protect against harmful irritants and chemicals. Another physiological regulatory process, the renin angiotensin system (RAS), plays an important role in the pathology of many diseases. Angiotensin converting enzyme (ACE) is a key ... more

C. Ayada; Ü. Toru; O. Genç; A. Yerlikaya; S. Sahin; S. Turgut; G. Turgut