Research Article

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12/17/2012
Early growth traits; Hu sheep; MC4R gene; Polymorphism

The melanocortin-4 receptor (MC4R) has important roles in regulating food intake, energy balance, and body weight in mammals. In pigs and cattle, MC4R mutations have been identified as genetic markers for growth and traits. Compared with abundant research conducted on other livestock species, little is known about mutations of the ovine MC4R gene. We investigated the ... more

X.M. Song; J.F. Jiang; G.Z. Zhang; F.X. Shi; Y.Q. Jiang
11/12/2012
Gastric cancer; Meta-analysis; Polymorphism; susceptibility; XRCC1

Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a ... more

B.M. Liu; T.M. Liu; B.S. You; H.Y. You; J. Yang; L. Li; Y.C. He
09/26/2012
Bladder cancer; Genetic susceptibility; hOGG1; Meta-analysis; Polymorphism

The functional polymorphism Ser326Cys (rs1052133) in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in bladder cancer risk. However, reports of this association between the Ser326Cys polymorphism and bladder cancer risk are conflicting. In order to help clarify this relationship, we made a meta-analysis of seven case-control studies, summing 2521 cases ... more

D.Y. Zhong; H.Y. Chu; M.L. Wang; L. Ma; D.N. Shi; Z.D. Zhang
09/25/2012
Colorectal cancer; Interleukin-10; Meta-analysis; Polymorphism

In order to make a comprehensive assessment of the potential association between two genetic variants in the IL-10 gene promoter, -1082 A>G (rs1800896) and -592 C>A (rs1800872), and colorectal cancer (CRC) risk, we conduced a meta-analysis of seven epidemiological studies, which included 1469 colorectal cancer cases and 2566 controls. Neither of the two polymorphisms had any ... more

Y.M. Zhang; X.C. Zhou; Z. Xu; C.J. Tang
09/17/2012
Hybrid identification; Inter-simple sequence repeat; Molecular marker; Polymorphism

Mungbean improvement via hybridization requires the identification of true F1 hybrids from controlled crosses before further generations of selfing/crossing and selection. We utilized inter-simple sequence repeat (ISSR) markers for identifying putative F1 hybrids from six cross combinations whose morphological characteristics were very similar to those of their ... more

P. Khajudparn; T. Prajongjai; O. Poolsawat; P.A. Tantasawat
09/03/2012
Colorectal cancer; CYP2E1; Polymorphism

We investigated a possible association between alcoholism, cigarette smoking, obesity and CYP2E1 RsaI and 96-bp insertion genetic polymorphisms with risk for colorectal cancer (CRC). Patients with CRC (70 women and 61 men) were matched for gender and age to 206 healthy controls. The mean age of the two groups was 62 years. Meat intake, cigarette smoking and alcohol drinking were ... more

T.D. Silva; A.V. Felipe; C.A.M. Pimenta; K. Barão; N.M. Forones
08/31/2012
Cancer susceptibility; Gender; miR-146a; Polymorphism; Smoking

Evidence has shown that miR-146a is involved in carcinogenesis, and a common G/C variant (rs2910164) in the pre-miR-146a gene has been associated with various types of cancer. We summarized the data from 22 published case-control studies on the association between rs2910164 and cancer risk and performed subgroup analyses by ethnicity, gender and smoking status. We found a ... more

A.X. Wang; B. Xu; N. Tong; S.Q. Chen; Y. Yang; X.W. Zhang; H. Jiang; N. Liu; J. Liu; X.N. Hu; G.Z. Sha; M. Chen
09/13/2012
GSTM1; Polymorphism; Primary open-angle glaucoma

Primary open-angle glaucoma (POAG) is characterized by loss of retinal ganglion cells, optic nerve damage and irreversible loss of visual field. Glaucoma is the second leading cause of blindness worldwide. It was estimated that in 2010 there were about 60.5 million glaucoma cases worldwide; among these patients, 4.5 million will become bilaterally blind. Glutathione S-transferases (GST) ... more

A.M. Barbosa; A.B. Frare; N.B. Costa; R.E. Silva; K.K.V.O. Moura
08/29/2012
ANAPC13; Body measurement traits; Cattle; PCR-SSCP; Polymorphism

Body measurement traits, influenced by genes and environmental factors, play numerous important roles in the value assessment of productivity and economy. There has been some indication that ANAPC13 influences adult height. We used PCR-SSCP and DNA sequencing technology to identify polymorphisms in the ANAPC13 gene. A polymorphism in intron 1 (A > G at base 17) was identified and an ... more

B.J. Jiang; X.L. Zhan; C.Z. Fu; H.B. Wang; G. Cheng; L.S. Zan
08/06/2012
EST-SSRs; Molecular markers; Musella; Polymorphism; Transferability

We assembled 31,308 publicly available Musa EST sequences into 21,129 unigenes; 4944 of them contained 5416 SSR motifs. In all, 238 unigenes flanking SSRs were randomly selected for primer design and then tested for amplification in Musella lasiocarpa. Seventy-eight primer pairs were found to be transferable to this species, and 49 displayed polymorphism. A set of 34 ... more

W.J. Li; H. Ma; Z.H. Li; Y.M. Wan; X.X. Liu; C.L. Zhou

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