Research Article

Related GMR Articles

08/21/2013
GSEA; Osteoarthritis; PPAR signaling pathway; Rheumatoid arthritis

Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives are still being sought. We applied gene set-enrichment analysis to microarray datasets of RA and OA to look for regulatory mechanisms. We ... more

C.Q. Yi; C.H. Ma; Z.P. Xie; Y. Cao; G.Q. Zhang; X.K. Zhou; Z.Q. Liu
03/13/2013
MicroRNA network; Osteoarthritis; PPI network; Protein-protein interaction

Osteoarthritis is the most common form of arthritis among elderly adults. Herein, we performed protein-protein interaction (PPI) and miRNA network analysis to evaluate the global correlation between miRNA regulation and the PPI network in human osteoarthritis. Our results showed that desmoplakin (DSP), cystatin A (CSTA), calmodulin 1, tyrosine kinase endothelial, insulin-like growth ... more

M. Wang; C. Liu; Y. Zhang; Y. Hao; X. Zhang; Y.M. Zhang
04/26/2013
Differentially expressed gene; Disc degeneration; Dysfunctional pathway

Disc degeneration is strongly associated with back or neck pain, sciatica, and disc herniation or prolapse. It places an enormous economic burden on society and can greatly affect quality of life. Alternative treatment approaches, such as genetic therapies, are urgently needed to slow or reverse the disc degeneration process. We downloaded gene expression data from Gene Expression Omnibus ... more

Y. Chen; K. Chen; M. Li; C. Li; H. Ma; Y.S. Bai; X.D. Zhu; Q. Fu
01/08/2014
Differentially expressed gene; Function enrichment analysis; Microarray; Preadipocytes

We looked for differentially expressed genes at different stages of preadipocyte differentiation and examined their functions, based on DNA microarrays of preadipocytes obtained from healthy subjects undergoing cosmetic liposuction. We downloaded gene expression profile GSE25910 from the Gene Expression Omnibus database and identified the differentially expressed genes with packages in R ... more

J.Y. Du; H. Yang; D.R. Tian; Q.M. Wang; L. He
06/18/2015
cDNA-SRAP; Differentially expressed gene; Real-time qPCR; Sporisorium scitamineum; Sugarcane

Sugarcane smut, caused by the fungus Sporisorium scitamineum, is one of the main diseases that affect sugarcane worldwide. In the present study, the cDNA-SRAP technique was used to identify genes that are likely to be involved in the response of sugarcane to S. scitamineum infection. In total, 21 bands with significant differential expression during cDNA-SRAP ... more

N. Huang; Y.Y. Zhang; X.H. Xiao; L. Huang; Q.B. Wu; Y.X. Que; L.P. Xu
11/07/2013
ADAMTS14; Osteoarthritis; PCR-RFLP; rs4747096; Thai population

Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. This disease is characterized by breakdown and loss of articular cartilage due to genetic, mechanical and environmental factors. Although the pathophysiology of OA is not completely known, several candidate genes have been reported to be associated with OA susceptibility. We assessed the association between ... more

T. Poonpet; S. Honsawek; N. Tammachote; S. Kanitnate; R. Tammachote
12/12/2014
HIF-1a; Osteoarthritis; Radiographic severity; Synovial fluid

Osteoarthritis (OA) is primarily characterized by articular cartilage degradation. Hypoxia-inducible factor-1a (HIF-1a), a subunit of the basic helix-loop-helix-containing PER-ARNT-SIM (PAS) domain transcription factors, plays a vital role in the survival of articular chondrocytes to the hostile hypoxic microenvironment and complicates the progression of OA. In this study, we examined ... more

H. Chu; Z.M. Xu; H. Yu; K.J. Zhu; H. Huang
11/14/2014
ADAMTS; MMP; Osteoarthritis

We compared serum levels of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, ADAMTS-5, matrix metalloproteinase (MMP)-1, and MMP-3 in patients with different stages of knee osteoarthritis (OA), and investigated the clinical significance of diagnosing OA in early stages. OA patients were divided into 2 groups: early OA group (44 cases), intermediate and advanced ... more

W. Li; C. Du; H. Wang; C. Zhang
10/18/2013
DEGs; Function analysis; Osteoporosis; Protein-protein interaction network

This study used DNA microarray data to identify differentially expressed genes of osteoporosis and provide useful information for treatments of the disease. We downloaded gene expression data of Osteoporosis GSE35956 from the Gene Expression Omnibus database, which included five normal and five osteoporosis samples. We then identified the differentially expressed genes between normal and ... more

X.M. Wu; X. Ma; C. Tang; K.N. Xie; J. Liu; W. Guo; Y.L. Yan; G.H. Shen; E.P. Luo
10/10/2013
Differential expression; Duchenne muscular dystrophy; Protein-protein interaction network

Duchenne muscular dystrophy (DMD), which is caused by mutations in the X-linked dystrophin gene, is a severe and progressive neuromuscular disease with no available cure. By integrating 2 microarray datasets from the Gene Expression Omnibus, we identified differentially expressed genes in 2 stages of DMD and systematically explored their potential disease-related mechanisms using a ... more

D. Wang; Z.J. Wang; X.X. Song; L.H. Pu; X. Li; Y. Wang

Pages