Research Article

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Toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP; also known as MAL) is an essential adaptor molecule in Toll-like receptor signaling, involved in activating the innate immune response during infection. Genetic variations in the TIRAP gene may influence human susceptibility to infectious disease. To date, in the Chinese population, a possible ... more

Y.X. Zhang; Y. Xue; M.Y. Zhao; H.J. Wang; J.C. Li; J.Y. Liu; F.J. Li; J.M. Zhou
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Disease susceptibility; MD-2; Single-nucleotide polymorphisms; Tuberculosis

Myeloid differentiation-2 (MD-2) is an essential component of the CD14-TLR4/MD-2 receptor complex involved in microbial cell wall component recognition during infection. Genetic variations in the MD-2 gene may influence human susceptibility to infectious diseases. To date, a predisposition of MD-2 gene variants to contract tuberculosis has not been reported. We investigated whether MD-2 ... more

Y. Xue; Z.Q. Zhao; D. Hong; M.Y. Zhao; Y.X. Zhang; H.J. Wang; Y. Wang; J.C. Li
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Diagnosis; Pulmonary; Sputum; Surfactant protein-A; Tuberculosis

The aim of this study was to explore the diagnostic and differential diagnosis value of surfactant protein-A (SP-A) in the serum and sputum for pulmonary tuberculosis. A total of 101 patients with pulmonary tuberculosis, 85 healthy volunteers, and 30 chronic obstructive pulmonary disease (COPD) patients were divided into pulmonary tuberculosis group, healthy control group, and COPD group ... more

H. Hu; G.L. Teng; L.Z. Gai; Y. Yang; C.J. Zhu
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P2X7; Polymorphism; Tuberculosis

Susceptibility to tuberculosis may be influenced by variations in human genes. The P2X7 receptor is an ATP-gated cation channel expressed in immune cells, and it influences the release of proinflammatory cytokines from monocytes and macrophages. In the present study, we aimed to evaluate the impact of P2X7 gene rs2393799 (-762T/C) and rs1718119 (Thr348Ala) polymorphisms ... more

G. Bahari; M. Hashemi; M. Taheri; M. Naderi; A. Moazeni-Roodi; H.R. Kouhpayeh; E. Eskandari-Nasab
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CD14; Chinese Han; SNPs; Tuberculosis

Although the role of CD14 in mediating signals from Toll-like receptors to recognize Mycobacterium tuberculosis is known, how polymorphisms in this gene affect the susceptibility to develop tuberculosis are still not clear. We examined whether single nucleotide polymorphisms at positions -1145 and -159 in the promoter region of the CD14 gene are associated with tuberculosis in a ... more

M.Y. Zhao; Y. Xue; Z.Q. Zhao; F.J. Li; D.P. Fan; L.L. Wei; X.J. Sun; X. Zhang; X.C. Wang; Y.X. Zhang; J.C. Li
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Polymorphism; PTPN22; Tuberculosis

The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, which encodes an intracellular lymphoid-specific phosphatase, is considered an important regulator of T-cell activation. We investigated a possible association between the PTPN22 C1858T (R620W) polymorphism and pulmonary tuberculosis in an Iranian population. Single nucleotide polymorphisms of PTPN22 C1858T (rs2476601) ... more

H.R. Kouhpayeh; M. Hashemi; S.A. Hashemi; A. Moazeni-Roodi; M. Naderi; B. Sharifi-Mood; M. Taheri; M. Mohammadi; S. Ghavami
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Meta-analysis; Monocyte chemoattractant protein-1; Tuberculosis

Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and the risk of tuberculosis (TB). However, the results have been inconsistent and inconclusive. In this study, we performed a meta-analysis to evaluate the association between the MCP-1 -2518A/G polymorphism and TB. The ... more

G. Tian; X. Li; H. Li; X. Wang; B. Cheng

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