Research Article

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11/16/2010
CYP; GST; p53; Polymorphism; susceptibility; Thyroid disease

Specific genotypes appear to be related to the development of thyroid disease. We examined whether polymorphisms of the genes CYP1A1, GSTM1, GSTT1, and TP53 at codon 72 are associated with increased risk for thyroid nodules. Blood samples were obtained from 122 thyroid patients with nodules and from 134 healthy control individuals from Goiânia city, GO ... more

A.A.S. Reis; D.M. Silva; M.P. Curado; A.D. da Cruz
11/30/2010
Crustacean; Macrobrachium; Phylogenetic relathionship; Polymorphism; Prawn; RAPD-PCR

The prawn genus Macrobrachium belongs to the family Palaemonidae. Its species are widely distributed in lakes, reservoirs, floodplains, and rivers in tropical and subtropical regions of South America. Globally, the genus Macrobrachium includes nearly 210 known species, many of which have economic and ecological importance. We analyzed three species of this genus (M. ... more

A.L. Guerra; A.V.B. Lima; F.G. Taddei; L. Castiglioni
10/26/2010
ACE gene; GSTM1; GSTT1; Polymorphism; Retinopathy of prematurity

One of the most frequently observed causes of blindness in infancy is the pathogenesis known as retinopathy of prematurity (ROP). Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system; it is involved in the development of cardiovascular system diseases linked to I/D polymorphism of the ACE gene. Glutathione-S-transferase enzyme (GST) is one of ... more

M. Yildiz; M. Karkucak; T. Yakut; O. Gorukmez; A. Ozmen
09/21/2010
Endothelial nitric oxide synthase; Essential hypertension; Meta-analysis; Polymorphism

We examined the effect of polymorphisms in the endothelial nitric oxide synthase gene on the risk for essential hypertension in a Han Chinese population through a meta-analysis of data from 15 studies. Associations between increased risk for essential hypertension and 4b/a were obtained in a dominant model and allele contrast (aa + ab vs bb: odds ratio (OR)FE = 1.26, ... more

H.G. Wang; J.L. Wang; P. Chang; F.L. Cao; X.C. Liu; Y.B. Ma; G.X. Zhai; H.Q. Gao
08/31/2010
Breast cancer; D‑loop; mtDNA; Polymorphism

A high incidence of somatic mtDNA polymorphisms has been reported in a wide variety of human cancers; some of them have been proposed as markers for the early detection of breast cancer. However, little attention has been paid to the potential of germline mitochondrial sequence variations as genetic risk factors for cancer. We performed a case-control study of 70 unrelated Tunisian women ... more

Y. Loueslati; W. Troudi; L. Cherni; K.B. Rhomdhane; L. Mota-Vieira
07/20/2010
Adiponectin; Adrenergic receptor; Cardiometabolic risk factor; Obesity; Polymorphism

We determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers ... more

V.A. Genelhu; E.A. Francischetti; S.F.P. Duarte; B.M.J. Celoria; R.C. Oliveira; P.H. Cabello; M.M.G. Pimentel
07/13/2010
Coronary artery disease; Inflammation; Polymorphism; PPAR-δ

Peroxisome proliferator-activated receptor delta (PPAR-δ) is a transcription factor implicated in metabolism and inflammation. The +294T/C polymorphism in the PPAR-δ gene is associated with risk of coronary artery disease (CAD) in dyslipidemic women and hypercholesterolemic men. Whether this polymorphism influences the risk of CAD in the absence of dyslipidemia was not known, so we ... more

I. Jguirim-Souissi; A. Jelassi; Y. Hrira; M. Najah; A. Slimani; F. Addad; M. Hassine; K.B. Hamda; F. Maatouk; M. Rouis; M.N. Slimane
07/06/2010
Inner Mongolia; Metabolic lipid disorders; Polymorphism; PPARg2-Pro12Ala; Primary hypertension

In order to determine whether Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 (PPARγ2) gene contributes to susceptibility to primary hypertension and metabolic lipid disorders, 482 unrelated subjects from Inner Mongolia were studied, including 137 healthy normotensive (controls) and 345 hypertensive subjects. PCR-RFLP was used to determine the genotypes of ... more

L. Gao; L. Wang; H. Yun; L. Su; X. Su
07/27/2010
Biomphalaria; Genetic variability; Polymorphism; RAPD-PCR; Schistosoma mansoni

Despite the implementation control programs, schistosomiasis continues to spread throughout the world. Among modern control strategies, vector control is currently being emphasized. Within this context, analysis of the genetic variability of intermediate host snails (Biomphalaria spp) is important because it allows identification of specific sequences of the genome of this ... more

A.L.D. Oliveira; D. Da Silva; B.C. Manzano; A.Z. Abdel-Hamid; M.Y. Marcelino; E.M. Zanotti-Magalhães; E.M. Zanotti-Magalhães; L.A. Magalhães; J.T. Ribeiro-Paes
06/11/2010
Breast cancer; Drug therapy; Genetic; Glutathione transferase; Polymorphism

The glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione. We examined whether GSTT1/GSTT1“null”, GSTM1/GSTM1“null” and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associated with different response rates to neoadjuvant ... more

A.L. Oliveira; F.F.O. Rodrigues; R.E. Santos; T. Aoki; M.N. Rocha; C.A. Longui; M.B. Melo

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