Research Article

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02/02/2015
Gestational diabetes; Macrophage migration inhibitory factor; Polymorphism; rs1007888; Single-nucleotide polymorphism

We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study. Differences in the MIF rs1007888 genotype and allele ... more

Y. Zhan; C. Li; J. Chen; S. Yu; Q. Gao; Y.P. Wang; S.G. Liu
01/26/2015
Insulin resistance; Meta-analysis; Obesity; Polymorphism; TNF-α

Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conf‍‍licting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE and EMBASE). No evidence of ... more

H.G. Wang; J. Yang; H. Han; F. Xu; Y. Bian; H. Zhang; J.L. Wang
01/23/2015
Fatty liver; L-FABP gene; Landes geese; Polymorphism; Tissue expression

Liver weight is an important economic trait in the fatty goose liver industry. Liver-type fatty acid binding protein (L-FABP) is involved in the formation and metabolism of fatty acids. Thus, we hypothesized that sequence polymorphisms in L-FABP were associated with fatty liver weight in goose. We first isolated, sequenced, and characterized the goose L-FABP gene, which ... more

Z. Song; D. Shao; X.X. Sun; J.W. Niu; D.Q. Gong
01/15/2015
Microsatellites; Polymorphism; Sinonovacula constricta

The razor clam, Sinonovacula constricta, is an important commercial bivalve and a popular mollusca food in China. Twelve polymorphic microsatellite markers were isolated from the razor clam using a partial genomic library enriched for tandem repeat sequences of (CA)16, (GA)16. Polymorphisms of these loci were evaluated in a wild population of 30 individuals ... more

H.T. Ma; H.B. Jiang; X.Q. Liu; X.P. Wu; X.M. Wei
01/15/2015
Gene; Liver X receptor a; Polymorphism; Stroke

We examined the relationship between the liver X receptor a gene (LXRα) rsl2221497 polymorphism and the susceptibility to ischemic stroke in a Chinese population. The polymerase chain reaction-restriction fragment length polymorphism technique was used to detect the genotype of rsl2221497 in the LXRαgene of 300 stroke patients and 300 healthy control ... more

H.X. Wang; K. Zhang; L. Zhao; J.W. Tang; L.Y. Gao; Z.P. Wei
08/03/2010
Chinese Han population; Rheumatoid arthritis; Single-nucleotide polymorphism; Suppressor of cytokine signaling-3 (SOCS-3)

Suppressor of cytokine signaling (SOCS)-3 is a key negative regulator of cytokine signaling that inhibits the JAK/STAT signal transduction pathway; there are reports describing its role in attenuating arthritis through SOCS-3 overexpression. We examined the relationship between polymorphisms in the coding sequence and promoter region of SOCS-3 and rheumatoid arthritis (RA) in a ... more

L.P. Sun; X.L. Ma; H.X. Liu; Y.S. Wang; X.F. Li
12/17/2012
Breast cancer; Chinese Han population; MHC class-III; Single nucleotide polymorphism

Polymorphisms of the major histocompatibility complex (MHC) have been linked to many diseases, especially autoimmune disorders. Previous studies have shown that genetic variants in MHC class III are associated with breast cancer. To determine if there is an association between MHC class III and breast cancer risk in the Chinese Han population, we carried out a hospital-based case-control ... more

Q. Pan; Y. Ning; L.Z. Chen; S. Zhang; Z.Z. Liu; X.X. Yang; W. Wei; H. Wei; Q.G. Li; H.N. Yue; J.X. Wang
09/23/2013
Chinese Hui population; eNOS gene; Essential hypertension; Polymorphisms

We investigated a possible association of polymorphism of the eNOS gene and essential hypertension in the Chinese Hui population; polymorphisms of rs2070744 (T>C), rs1799983 (G>T), rs1800780 (A>G), and rs3918181 (A>G) loci of the eNOS gene were examined. We found that the genotypic frequencies at rs1799983 and rs1800780 loci differed significantly between patients with ... more

B. Yang; J.R. Xu; X.M. Liu; Y. Yang; X.F. Na; M. Li; Y.J. Wang
06/11/2015
FokI polymorphism; Tuberculosis; Vitamin D receptor

Numerous studies have evaluated the association between FokI polymorphisms in the vitamin D receptor (VDR) gene and tuberculosis risk. However, the specific association remains controversial. In this study, we performed a meta-analysis to assess the association between the VDR gene FokI polymorphism and tuberculosis. Published studies from the PubMed and Embase ... more

Y.P. Sun; Q.S. Cai
09/28/2015
Case-control study; Dental caries; Gene polymorphism; Vitamin D receptor

Environmental influences on the development and progression of dental caries are well known; however, there is little evidence of a genetic component imparting susceptibility to dental caries. The aim of this study was to investigate the relationship between a single nucleotide polymorphism in the vitamin D receptor TaqI locus and dental caries susceptibility in a Chinese ... more

X.P. Hu; Z.Q. Li; J.Y. Zhou; Z.H. Yu; J.M. Zhang; M.L. Guo

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