Research Article

Related GMR Articles

09/23/2013
Anticytotoxicity; Antigenotoxicity; Bacteria; Lafoensia pacari; Mice; Pacari

Lafoensia pacari (Lythraceae), popularly known in Brazil as "pacari", is a small tree native to the Cerrado that is used in folk medicine to treat cancer and as an anti-inflammatory and cicatrizing agent. We evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of an ethanol extract of L. pacari stem bark (EESB) using the Ames test and the mouse ... more

D.C.S. Lima; C.R. Silva; B.L. Sampaio; J.R. de Paula; L. Chen-Chen
03/31/2004
Antibiotics; Chromobacterium violaceum; Resistance

Chromobacterium violaceum is a free-living bacterium commonly found in aquatic habitats of tropical and subtropical regions of the world. This bacterium is able to produce a large variety of products of biotechnological and pharmacological use. Although C. violaceum is considered to be non-pathogenic, some cases of severe infections in humans and other animals have been reported ... more

F. Fantinatti-Garboggini; R. de Almeida; Vdo Amaral Portillo; T.A.P. Barbosa; P.Beltramini Trevilato; C.Eduardo Ra Neto; R.Duarte Coêlho; L.Aparecida Bartoleti; E.Seixas Hanna; M. Brocchi; G.P. Manfio; D.Wanderlei Silva
12/12/2014
Antibiotics; Hypopituitarism; Pituitary abscess

Pituitary abscess is a rare intrasellar infectious disease. It is usually treated with a combination of surgical drainage and intravenous antibiotics. We describe the case of a 38-year-old man with headache, fever, left earache, subsequent diabetes insipidus, and anterior pituitary insufficiency due to pituitary abscess, which was confirmed on the basis of clinical symptoms, laboratory ... more

H. Zhu; X.M. Gu; J. Hong; F.X. Shen
08/19/2015
Antibiotics; Berberine; Dairy cow mastitis; Staphylococcus epidermidis

Berberine is a plant alkaloid with antimicrobial activity against a variety of microorganisms. In this study, the antimicrobial properties of berberine against multi-drug resistant field isolates of Staphylococcus epidermidis were investigated using berberine alone or in combination with a commonly used antibiotics in veterinary clinics, including penicillin, lincomycin, and ... more

X. Zhou; C. Yang; Y. Li; X. Liu; Y. Wang
06/30/2005
ATP binding cassette transporters; Drug resistance; Major facilitator superfamily; Paracoccidioides brasiliensis

In the struggle for life, the capacity of microorganisms to synthesize and secrete toxic compounds (inhibiting competitors) plays an important role in successful survival of these species. This ability must come together with the capability of being unaffected by these same compounds. Several mechanisms are thought to avoid the toxic effects. One of them is toxin extrusion from the ... more

Cda Silva Costa; F.Caixeta Albuquerque; R.Vieira Andrade; G.Camilo de Oliveira; M.Fernandes de Almeida; Mde Macedo Brigido; Mde Macedo Brigido; A.Queiróz Maranhão; A.Queiróz Maranhão
12/19/2014
CD4+ and CD25+ T cells; Colitis; Drug resistance; IL-8; Immune status; NOS activity

We examined the relationship among the multidrug resistance (MDR1) gene product P-glycoprotein (P-gp), ulcerative colitis, and immune status under ulcerative colitis. MDR1 P-gp expression and interleukin-8 levels in ulcerative colitis were determined using immunohistochemistry and a double-antibody sandwich avidin-biotin complex-enzyme-linked immunosorbent assay, respectively. ... more

Y.J. Zhang; J.J. Xu; P. Wang; J.L. Wang
07/24/2014
Drug resistance; Methotrexate; Osteosarcoma; Reduced folate carrier

Osteosarcoma is a primary malignant tumor in adolescents, associated with high mortality and morbidity. The high-dose methotrexate (MTX) chemotherapy used to treat this disease may induce primary or secondary drug resistance, resulting in a reduced effect of comprehensive treatment. In this study, the relationship between reduced folate carrier (RFC) gene expression and intracellular drug ... more

J.J. Wang; G.J. Li
05/25/2015
Autophagy; Doxorubicin; Drug resistance; Myeloma; RPMI8226

We investigated the effect of autophagy on drug resistance of multiple myeloma (MM) to doxorubicin (DOX). A DOX-resistant MM cell line (RPMI8226/DOX) was developed by progressively increasing the DOX concentration gradient. The drug resistance index was determined using the MTT method. Transmission electron microscopy, anti-light chain 3-fluorescein isothiocyanate immunofluorescence, and ... more

Y.Z. Pan; X. Wang; H. Bai; C.B. Wang; Q. Zhang; R. Xi
05/12/2015
Ancylostoma caninum; ARMS-PCR; Beta-tubulin; Drug resistance; Megaprimer-PCR

Single nucleotide polymorphisms at codons 167, 198, and 200 in the β-tubulin isotype 1 gene have been associated with benz­imidazole resistance. Until now, the only mutation observed in Ancy­lostoma caninum was at codon 200 of this gene. However, the standard­ized methodologies used to detect mutations in this species are faulty. The objective of this study was to standardize a ... more

L.F. Furtado; É.M. Rabelo
08/16/2011
Bacteria; RNA-seq; Transcriptome

The large number of microbial genomes deposited in databanks has opened the door for in-depth studies of organisms, including post-genomics investigations. Thanks to new generation sequencing technology, these studies have made advances that have lead to extraordinary discoveries in bacterial transcriptomics. In this review, we describe bacterial RNA sequencing studies that use these new ... more

A.C. Pinto; H.P. Melo-Barbosa; A. Miyoshi; A. Silva; V. Azevedo

Pages