Research Article

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05/23/2014
Apoptosis; Bcl-2/Bax; Caspase-8; Fas/FasL; Nonalcoholic fatty liver disease

The aim of this study was to investigate the roles of Fas/FasL, Bcl-2/Bax, and Caspase-8 mRNA expressions in nonalcoholic fatty liver disease (NAFLD). The apoptosis percentage was measured by flow cytometry, the immunohistochemical assay was performed for the determination of Fas, FasL, Bcl-2, and Bax expressions, and a real-time polymerase chain reaction (PCR) assay was performed to ... more

C.P. Li; J.H. Li; S.Y. He; P. Li; X.L. Zhong
05/23/2014
Apoptosis; Cancer; Cytotoxicity; MCF-7; Saudi Arabia

This study investigated the in vitro anticancer activities of a total of 14 wild angiosperms collected in Saudi Arabia. The cytotoxic activity of each extract was assessed against human breast adenocarcinoma (MCF-7) cell lines by using the MTT assay. Among the plants screened, the potential cytotoxic activity exhibited by the extract of Lavandula dentata (Lamiaceae) was ... more

M.A. Ali; A. Farah; F.M. Al-Hemaid; F.M. Abou-Tarboush
02/13/2014
Apoptosis; Hela cells; Mechanism; Menispermum dauricum

Menispermum dauricum DC possesses a wide range of pharmacological effects. In this study, the mechanism of apoptosis induced by active components of M. dauricum was investigated in the human cervical carcinoma HeLa cell line. HeLa cells were treated with different M. dauricum concentrations over different time periods. The proliferation-inhibitory rate and ... more

J.Y. Wang; S. Sun; L. Liu; W.S. Yang
05/09/2014
Apoptosis; Bortezomib; NFkB pathway; Prostate cancer; Trichostatin A

Prostate cancer is one of the most common types of urological cancers. Despite the implementation of effective radiotherapy and chemotherapy methods, prostate cancer cells can still show resistance to treatment. In recent years, a combination of proteasome and histone deacetylase inhibitors has been used to treat various malignancies. In this study, we examined the cytotoxic and apoptotic ... more

I. Kiliccioglu; E. Konac; N. Varol; S. Gurocak; Y. Bilen
04/17/2014
A7r5 cells; Apoptosis; Caspase-3; Caspase-9; Low-frequency ultrasound

Ultrasound, a non-invasive therapy method, is a potential tool for medical applications, but its biological effects on vascular smooth muscle cells (VSMCs) have not been characterized. The aim of this study was to explore the effect and possible apoptotic mechanism of VSMCs that were induced by low-frequency ultrasound (LFU). Cell viability and apoptosis of A7r5 cells were evaluated after ... more

B. Zhang; H.S. Zhou; Q. Cheng; L. Lei; B. Hu
01/14/2014
Apoptosis; Granulosa cells; INHBB; miR-34a

During ovarian follicular growth and development, only a few follicles actually ovulate. Recently, it was found that follicular atresia is triggered by granulosa cell apoptosis, but the molecular mechanism of follicular atresia was not understood. Using flow cytometry, we found that miR-34a promotes granulosa cell apoptosis in pig ovarian follicles. In addition, inhibin beta B was found ... more

F. Tu; Z.X. Pan; Y. Yao; H.L. Liu; S.R. Liu; Z. Xie; Q.F. Li
03/24/2014
Apoptosis; Cell cycle; Gax; Migration; Proliferation; VSMCs

The Gax gene has been implicated in a variety of cell-developmental and biological processes, and aberrant Gax expression is linked to many diseases. In this study, to provide important insights for Gax-based gene therapy in vein graft restenosis and its anti-restenotic mechanism, we used rabbit vascular smooth muscle cells (VSMCs) to investigate the effects of ... more

H. Zheng; S. Xue; Z.L. Hu; J.G. Shan; W.G. Yang
03/12/2014
Apoptosis; Cell proliferation; Embryo; Guinea pig; Ovary

The guinea pig is an excellent animal model for studying reproductive biology of adult humans and most domestic animals. Yet, whether this animal might serve as a good model for embryonic stage investigations and determinations of signals affecting or directing ovary development remains unknown. These questions were addressed by examining morphological evolution and the expression of ... more

S.Y. Sun; W. Zhang; X. Han; R.H. Huang; F.X. Shi
01/21/2014
Apoptosis; Doxorubicin; Marsdenia tenacissima extract

Marsdenia tenacissima extract (MTE) is a new plate-derived biotechnology product that is frequently used, but occasionally reported, in the field of chemotherapy. In this study, we assessed the antitumor activity and related mechanisms of MTE by various biotechnological methods. The survival rates of MG63 osteosarcoma cells treated with MTE and doxorubicin were measured, ... more

T. Huang; W.H. Gong; C.P. Zou; X.C. Li; G.J. Jiang; X.H. Li; H. Qian
01/14/2014
Apoptosis; Endothelial progenitor cells; Ginkgo biloba extract; Superoxide dismutase

Although ginkgo biloba extract (GBE) was shown to have antioxidant effects, little has been reported on the ability to GBE to help endothelial progenitor cells (EPCs) resist oxidative stress. The present study evaluated the influence of different concentrations of GBE on superoxide dismutase (SOD) and apoptosis of diabetic peripheral blood EPCs. Twenty-five diabetic patients without any ... more

M. Zhao; X.X. Wang; W.H. Wan

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