Research Article

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12/19/2014
Apoptosis; Cytochalasin B; Glioma; mitosis

Cytochalasin B (CB) is known to inhibit a number of cancer types, but its effects on gliomas are unknown. We examined the in vitro effects of CB on the proliferation of human glioma U251 cells, as well as determined its mechanism of action. Cell proliferation was determined using CCK-8. The effect of CB on U251 cell morphology was observed under a transmission electron microscope ... more

Z.G. Tong; N. Liu; H.S. Song; J.Q. Li; J. Jiang; J.Y. Zhu; J.P. Qi
10/27/2014
Apoptosis; Apoptotic protein; Ischemia-reperfusion; NGAL; Tubular epithelial cells

This study aimed to determine the protective effect and mechanism of neutrophil gelatinase-associated lipocalin (NGAL) in rat kidney on ischemia/reperfusion injury (I/R). The rat I/R model was set up by cutting one kidney and clamping the contralateral renal pedicle for 45 min. Male SD rats were randomly divided into sham-operation, I/R and NGAL groups. Hematoxylin-eosin staining was ... more

X.J. Zang; S.X. An; Z. Feng; Y.P. Xia; Y. Song; Q. Yu
10/31/2014
Antigenotoxicity; Apoptosis; Necrosis; Tephrosia cinerea

Tephrosia cinerea L. (Pers.) is a tropical species that exhibits antileishmanial activity in Leishmania amazonensis promastigote cultures and is commonly used to treat infections, inflammations, ulcers, nervous conditions, and diarrhea. However, no studies have investigated its effects on genetic material. Therefore, we evaluated the genotoxic potential, antigenotoxic ... more

A.C.S. Dias; V.R. Moreira; L.P. Almeida; M.I.S. Lima; J.L. Bezerra; M.N.S. Ribeiro; F.R.F. Nascimento; S.R.F. Pereira
08/28/2014
Apoptosis; Gastric cancer; Small interfering RNA; Survivin

A pair of inverted repeated sequences of the gene survivin was designed for stable double-stranded RNA establishment. After stable transfection, the biological behaviors of gastric cancer cells were observed. The interference rates of survivin-targeting siRNA (siRNA-survivin) in BGC823, MKN45, SGC7901, and cisplatin-resistant SGC7901 groups were 55.363 ± 3.974 ... more

Y.H. Li; M. Chen; M. Zhang; X.Q. Zhang; S. Zhang; C.G. Yu; Z.M. Xu; X.P. Zou
08/28/2014
Apoptosis; Follicular atresia; Fox O1

Follicular atresia, a key phenomenon in follicle development, eliminates most of the follicles in mammalian ovaries. To investigate the molecular mechanism of follicular atresia in porcine ovaries, we investigated the mRNA expression of three important cell death ligand-receptor systems and Fox O1 in follicles with a diameter of 3-5 mm. The phosphorylation and subcellular localization of ... more

F. Lin; Y.H. Fu; J. Han; M. Shen; C.W. Du; R. Li; X.S. Ma; H.L. Liu
08/25/2014
Apoptosis; Apoptotic genes; Icariin; Nephrectomy

The aim of this study was to investigate the renal protective effect of icariin in 5/6 nephrectomized rats and the molecular mechanisms involved. Forty male Sprague-Dawley rats were randomly divided into 5 groups: sham-operated group, 5/6 nephrectomy model group, icariin groups (20 and 40 mg/kg), and benazepril group. After 12-weeks treatment, 24-h urine and serum were collected, and ... more

S.R. Liang; J.W. Bi; Z.L. Guo; Y. Bai; Z. Hu
07/29/2014
Acrylonitrile; Apoptosis; Brain neuron; Neuron morphology; Rat

This study aimed to evaluate the effects of acrylonitrile (ACN) on neuronal morphology and apoptosis in rats. An ACN solution was administered to Wistar rats by gavage at doses of 0, 5, 10, or 20 mg/kg, 5 days a week for 13 weeks. The morphology of neurons and the presence of apoptosis was examined by light and electron microscope, DNA electrophoresis, immunohistochemistry, and terminal ... more

C.Z. Li; L.A. Tse; Y.L. Zhou; W. Fan; M. Li; I.T.S. Yu; T.Y. Jin
07/24/2014
Apoptosis; Guanine nucleotide-binding protein; Pig; Thyroid gland

The Alpha subunit of the stimulatory guanine nucleotide-binding protein (GNAS) is a complex imprinted gene. The major product of the GNAS gene is the α-subunit of the guanine nucleotide-binding protein (Gas), which plays a key role in multiple signal transduction pathways. Gas is required for the production of the receptor-stimulated intracellular cyclic adenosine monophosphate ( ... more

J. Peng; Y.L. Li; Y.F. Shen; Y. Wang; N.Y. Xu
07/07/2014
Apoptosis; Aspirin; Proliferation; Thy-1; Wnt/β-catenin

Cancer stem cells have been found to play important roles in carcinoma. Although thy-1 has been identified as a potential stem cell marker of liver cancer, whether the Wnt/β-catenin signaling pathway plays an important role in regulating hepatocarcinoma proliferation and apoptosis mediated by thy-1 remains unknown. Our results showed that high thy-1 expression caused hepG2 cells ... more

B.Q. Cheng; Y. Jiang; Q. Zhu; W.G. Lin
05/30/2014
Apoptosis; Fas/FasL; Severe aplastic anemia

Fas/FasL protein expression of bone marrow hematopoietic cells was investigated in severe aplastic anemia (SAA) patients. Fas expression was evaluated in CD34+, GlycoA+, CD33+, and CD14+ cells labeled with monoclonal antibodies in newly diagnosed and remission SAA patients along with normal controls. FasL expression was evaluated in CD8+ ... more

C.Y. Liu; R. Fu; H.Q. Wang; L.J. Li; H. Liu; J. Guan; T. Wang; W.W. Qi; E.B. Ruan; W. Qu; G.J. Wang; H. Liu; Y.H. Wu; J. Song; L.M. Xing; Z.H. Shao

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