Research Article

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07/07/2014
Apoptosis; Aspirin; Proliferation; Thy-1; Wnt/β-catenin

Cancer stem cells have been found to play important roles in carcinoma. Although thy-1 has been identified as a potential stem cell marker of liver cancer, whether the Wnt/β-catenin signaling pathway plays an important role in regulating hepatocarcinoma proliferation and apoptosis mediated by thy-1 remains unknown. Our results showed that high thy-1 expression caused hepG2 cells ... more

B.Q. Cheng; Y. Jiang; Q. Zhu; W.G. Lin
03/24/2014
Apoptosis; Cell cycle; Gax; Migration; Proliferation; VSMCs

The Gax gene has been implicated in a variety of cell-developmental and biological processes, and aberrant Gax expression is linked to many diseases. In this study, to provide important insights for Gax-based gene therapy in vein graft restenosis and its anti-restenotic mechanism, we used rabbit vascular smooth muscle cells (VSMCs) to investigate the effects of ... more

H. Zheng; S. Xue; Z.L. Hu; J.G. Shan; W.G. Yang
06/26/2015
Differentiation; Erythropoietin; Mesenchymal stem cell; Proliferation; Signaling pathways

We examined whether erythropoietin (EPO) can inhibit adipogenic differentiation of mesenchymal stem cells (MSCs) in the mouse bone marrow and its underlying mechanism. We separated and extracted mouse bone marrow MSCs and induced adipogenic differen­tiation using 3-isobutyl-1-methylxanthine, insulin, and dexamethasone. Different concentrations of EPO were added to the cells and observed ... more

G.X. Liu; J.C. Zhu; X.Y. Chen; A.Z. Zhu; C.C. Liu; Q. Lai; S.T. Chen
02/06/2015
Apoptosis; Curcumin; Invasion; Melanoma; Migration; Proliferation

Malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. Curcumin is extracted from Curcuma longa L.; curcumin has anti-tumor efficacy in multiple systemic malignancies. Here, we investigated the effect of curcumin on A375 human melanoma cells. A375 cells were cultivated, passaged, and treated with different concentrations of curcumin. We ... more

Y.P. Zhang; Y.Q. Li; Y.T. Lv; J.M. Wang
01/15/2015
Apoptosis; BPH-1 cells; Cell cycle; Croton membranaceus; Proliferation

Croton membranaceus aqueous root extract (CMARE) is among the widely used phytotherapeutics in Ghana for the management of benign prostatic hyperplasia (BPH) and prostate cancer. However, the mechanism of action of CMARE remains to be elucidated. This study aimed to establish whether apoptosis is involved in the antiproliferative effect of CMARE on human BPH-1 cells. We ... more

D.K. Afriyie; G.A. Asare; K. Bugyei; J. Lin; J. Peng; Z. Hong
12/12/2014
Hypoxia; Lewis lung carcinoma cell; Renin-angiotensin system; Vascular endothelial growth factor-A

The renin-angiotensin system (RAS) influences cancer biology and is frequently dysregulated in malignancy. However, regulation of tumor local RAS remains poorly understood. Hypoxia is a hallmark of solid tumors and affects nearly every major aspect of cancer biology. Previous studies have shown that hypoxia can regulate RAS expression in somatic tissues and cells. The aim of this study ... more

L. Fan; Y. Feng; H.Y. Wan; L. Ni; Y.R. Qian; Y. Guo; Y. Xiang; Q.Y. Li
09/28/2015
Gene expression; Hypoxia; Muscle; Pig

Hypoxia influences many physiological processes, such as respiration, cardiovascular, neurophysiology, and digestion. Skeletal muscle is an important motor organ, which relies on oxygen of oxidation; however, the study of hypoxia in skeletal muscle is lacking. In order to understand the effect of hypoxia on skeletal muscle, we determined the expression level of four hypoxia-related genes ( ... more

J. Zhang; L. Chen; K.R. Long; Z.P. Mu

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