Research Article

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The guinea pig is an excellent animal model for studying reproductive biology of adult humans and most domestic animals. Yet, whether this animal might serve as a good model for embryonic stage investigations and determinations of signals affecting or directing ovary development remains unknown. These questions were addressed by examining morphological evolution and the expression of ... more

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Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and is considered essential for tumor growth and progression. However, the function of FOXO1 in human cervical cancer remains unclear. In this study, we investigated the role of FOXO1 in cervical cancer. Our results showed that FOXO1 expression was lower in cervical cancer than in cervical ... more

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Apoptosis; Cell proliferation; FAS ligand (FASLG); Liver regeneration; MicroRNA-21 (miR-21)

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DNA damage; DNA repair; Drug metabolism; Escherichia coli mutagenesis; Oxidative stress; Yeast

The sensitivity responses of seven pso mutants of Saccharomyces cerevisiae towards the mutagens N-nitrosodiethylamine (NDEA), 1,2:7,8-diepoxyoctane (DEO), and 8-hydroxyquinoline (8HQ) further substantiated their allocation into two distinct groups: genes PSO1 (allelic to REV3), PSO2 (SNM1), PSO4 (PRP19), and PSO5 ... more

C. Pungartnik; J. Picada; M. Brendel; J.A.P. Henriques
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Chromobacterium violaceum is a Gram-negative β-proteobacterium that inhabits a variety of ecosystems in tropical and subtropical regions, including the water and banks of the Negro River in the Brazilian Amazon. This bacterium has been the subject of extensive study over the last three decades, due to its biotechnological properties, including the characteristic violacein ... more

F.Teixeira Duarte; F.Marques de Carvalho; U.Bezerra e Silva; K.Castanho Scortecci; C.Alfredo Ga Blaha; L.Fassarella Agnez-Lima; S.Regina Bat de Medeiros
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DNA repair; Escherichia coli; Functional complementation

The bacteria Escherichia coli has been widely employed in studies of eukaryotic DNA repair genes. Several eukaryotic genes have been cloned by functional complementation of mutant lineages of E. coli. We examined the similarities and differences among bacterial and eukaryotic DNA repair systems. Based on these data, we examined tools used for gene cloning and ... more

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Cell cycle; DNA repair; DNA replication; Paracoccidioides brasiliensis; Recombination; Transcriptome

DNA replication, together with repair mechanisms and cell cycle control, are the most important cellular processes necessary to maintain correct transfer of genetic information to the progeny. These processes are well conserved throughout the Eukarya, and the genes that are involved provide essential information for understanding the life cycle of an organism. We used computational ... more

V.Castelo Br Reis; F.Araripe Go Torres; M.José Poças-Fonseca; M.Teixeira De-Souza; D.Paulo de Souza; J.Ricardo Mo Almeida; C. Marinho-Silva; N.Skorupa Parachin; Ada Silva Dantas; T.Machado Mello-de-Sousa; L.Maria Pepe de Moraes
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Base excision repair; DNA damage; DNA repair; Genome maintenance; Heterologous complementation; Nucleotide excision

Nucleotide excision repair (NER) acts on a broad spectrum of large lesions, while base excision repair removes individual modified bases. Although both processes have been well studied in human cells, novel genes involved in these DNA repair pathways have been described. Using a heterologous complementation approach, we identified a fetal human cDNA that complemented two Escherichia coli ... more

D.O. Lopes; F.C. Falconi; A.M. Goes; Y. Canitrot; J.S. Hoffmann; C. Cazaux; G.R. Franco; A.M. Macedo; S.D.J. Pena; C.R. Machado
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checkpoint; DNA repair; DNA replication; Proliferating cell nuclear antigen; Rad17/Mec3/Ddc1; Saccharomyces cerevisiae

DNA damage activates several mechanisms such as DNA repair and cell cycle checkpoints. The Saccharomyces cerevisiae heterotrimeric checkpoint clamp consisting of the Rad17, Mec3 and Ddc1 subunits is an early response factor to DNA damage and activates checkpoints. This complex is structurally similar to the proliferating cell nuclear antigen (PCNA), which serves as a sliding clamp ... more

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DNA repair; Endometriosis; Polymorphism; XRCC3 Thr/Thr

Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. We investigated the association of polymorphisms in the DNA repair genes XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys with endometriosis risk. Genotypes were determined by PCR-RFLP assays in 52 patients with endometriosis and 101 age- ... more

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