Research Article

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11/02/2008
Gene expression profile; Myelodysplastic syndrome; Refractory anemia with excess blasts; Serial analysis of gene expression methodology

The molecular pathogenesis of myelodysplastic syndromes (MDS) is poorly understood. In order to expand our knowledge of genetic defects in MDS, we determined the overall profile of genes expressed in bone marrow from patients with refractory anemia with excess blasts (RAEB) by serial analysis of gene expression (SAGE). The present report describes a partial transcriptome of RAEB bone marrow ... more

C.F. Mendiburu; W.A. Silva; O. Ricci; C.R. Bonini-Domingos; A.C. Fett-Conte
12/08/2011
Gene expression profile; Liver cancer; Physiological activity; Systems biology

Liver cancer (LC) is generally characterized by malignant cell proliferation and growth; it normally develops in stages that progress from non-specific injury of the liver to liver fibrosis, liver cirrhosis, dysplasia nodules, and liver carcinoma. We used a rat model of diethylnitrosamine (DENA)-induced LC; a Rat Genome 230 2.0 Array was used to detect gene expression profile of liver ... more

C.S. Xu; G.P. Wang; L.X. Zhang; C.F. Chang; J. Zhi; Y.P. Hao
12/19/2013
Bioinformatic analysis; Capsicum annuum L.; Gene expression profile; TAF10; TAF13

We isolated two TATA-binding protein-associated factor (TAF) genes, TAF10 and TAF13, from pepper (Capsicum annuum). The complete coding sequences were amplified using reverse transcriptase-PCR on the basis of conserved sequence information of eggplant and several other plant species. Nucleotide sequence analysis of these two genes revealed that the pepper ... more

J.F. Wen; J.L. Huo; H.X. Chen; C.H. Ma; H. Jiang; H.S. Zhu; H. Zhou; M.H. Deng
12/11/2013
Fatty acid accumulation; Gene expression profile; Tung oil; Vernicia fordii; VfDGAT2

The tung tree (Vernicia fordii Hemsl.; Vf) has great potential as an industrial crop owning to its seed oil that has multiple uses. Diacylglycerol acyltransferases (DGATs) catalyze the last and most committed step of triacylglycerol (TAG) biosynthesis. In order to examine the physiological role of the VfDGAT2 gene in the tung tree, we characterized its ... more

Q.Q. Cui; Y.C. Chen; X.J. Han; Z.Y. Zhan; L.Y. Lin; L.L. Si; Y.D. Wang
04/17/2013
ArcA1; Capsicum annuum L.; Gene expression profile; Heterotrimeric G protein beta 2 subunit

We isolated two transcription factor genes, heterotrimeric G protein beta 2 subunit (Gβ2) and ArcA1, from pepper (Capsicum annuum). The complete coding sequences were amplified using reversed transcriptase PCR based on conserved sequence information of Solanum lycopersicum and several other plant species. Nucleotide sequence analysis of these two genes revealed that the ... more

M.H. Deng; J.L. Huo; H.S. Zhu; H. Zhou; J.F. Wen
11/11/2014
Benign and malignant breast cancer; Gene expression profile; Gene-regulatory network; Network topological properties

The aim of this study was to explain the pathogenesis and deterioration process of breast cancer. Breast cancer expression profile data GSE27567 was downloaded from the Gene Expression Omnibus (GEO) database, and breast cancer-related genes were extracted from databases, including Cancer-Resource and Online Mendelian Inheritance In Man (OMIM). Next, h17 transcription factor data were ... more

D.B. Chen; H.J. Yang
01/17/2014
AN2; Bioinformatic analysis; Capsicum annuum L.; Gene expression profile; UPA20

The complete coding sequences (CDSs) of “Yunnan Purple Pepper No.1” (Capsicum annuum L.) AN2 and UPA20 genes were amplified using the reverse transcriptase polymerase chain reaction on the basis of the conserved sequence information of some Solanaceae plants and known highly homologous pepper expressed sequence tags. The nucleotide sequence analysis of these 2 ... more

H.X. Chen; H. Jiang; J.L. Huo; J.F. Wen; H.S. Zhu; C.H. Ma; H. Zhou; J.H. Lv; M.H. Deng
05/29/2015
Gene expression profile; Gene synergistic effect; Hepatocyte growth; Phospholipase C signaling pathway; Rat liver regeneration

In general, the phospholipase C (PLC) signaling pathway is involved in many physiological activities, including cell growth. However, little is known regarding how the PLC signaling pathway participates in regulating hepatocyte (HC) growth during liver regeneration (LR). To further explore the influence of the PLC signaling pathway on HCs at the cellular level, HCs of high purity and ... more

G.G. Xu; Z. Geng; X.C. Zhou; Y.G. He; T.T. He; J.X. Mei; Y.J. Yang; Y.Q. Liu; C.S. Xu
11/22/2013
Age; Breed; Chicken; Cholesterol content; Egg yolks; Layer

The objective of this study was to investigate the deposition rule of yolk cholesterol in Lushi Green-shelled and Silky Fowl layers. A total of 90 layers of each breed were selected at an age of 15 to 51 weeks. Productive performance was recorded on a weekly basis, whereas yolk cholesterol was determined at 4-week intervals from 21 to 51 weeks of age. The average yolk cholesterol content ... more

P.K. Yang; Y.D. Tian; G.R. Sun; R.R. Jiang; R.L. Han; X.T. Kang
12/17/2012
Chicken; DNA polymorphism; Egg production traits; PRLR gene

The identification and utilization of potential candidate genes with significant effects on economically important traits have become increasingly important in poultry breeding programs. The prolactin (PRLR) receptor is a specific receptor for prolactin, which is an anterior pituitary peptide hormone involved in various physiological activities and is essential for reproductive success. ... more

L. Zhang; D.Y. Li; Y.P. Liu; Y. Wang; X.L. Zhao; Q. Zhu

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