Research Article

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M. Martorell; J.A. Garcia-Garcia; D. Gomez-Cabrero; A. del Aguila
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We studied human papillomavirus (HPV) prevalence and genotype distribution among women in the Henan Province to provide epidemiological data as a means of preventing cervical cancer and developing a vaccine. A total of 14,873 samples were genotyped by using polymerase chain reaction reverse dot-blot. The overall HPV-positive rate in the sample was 23.98% (3566/14873), of which 69.01% ( ... more

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Cervical cancer; Genotyping; Human papillomavirus; Prophylactic vaccines

Human papillomavirus (HPV) has been extensively studied concerning genomic structure, infection mechanisms, and diversity of types, as well as disease progression stages and development of vaccines. HPV type prevalence can differ in specific populations in different countries, according to ethnicity. This is the first report of an integrated project to evaluate the incidence of HPV types ... more

M.F.P.T.Baldez da Silva; B.S. Chagas; V. Guimarães; L.M.C. Katz; P.M. Felix; P.M. Miranda; A.A. Lima; L.C. Arraes; D.B.G. Martins; J.L.Lima Filho; R.C. Stocco; S. Crovella; A.C. Freitas; W. Beçak
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Amazon region; Cervical cancer; HPV; PCR

Infection by human papillomavirus (HPV) is one of the primary causes of mortality by cancer in northern Brazil. Sexually active women from Manaus, Amazonas, without cytological alterations and women with pre-malignant and malignant cytological alterations were examined for HPV virus, identified via PCR and sequencing. The target region for this study was part of the L1 capsid gene of HPV ... more

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The methylation of tumor suppressor genes has been shown to be involved in many human cancers. 5-Aza-2’-deoxycytidine (5-Aza-CdR) can reactivate the expression of methylated tumor suppressor genes. In our study, 2 human cervical cancer cell lines, HeLa and SiHa, were treated with different concentrations (20, 10, 5, and 2.5 μM) of 5-Aza-CdR for 24, 48, and 72 h. After incubation, cells ... more

T.T. Yao; S.M. Mo; L.Y. Liu; H.W. Lu; M.L. Huang; Z.Q. Lin
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This study aimed to investigate the inhibition of vascular endothelial growth factor (VEGF) by small hairpin RNA (shRNA) interference combined with radiotherapy on the growth of cervical cancer SiHa cell xenografts in nude mice. The effective pVEGF-shRNA plasmid was screened by reverse transcription-polymerase chain reaction (RT-PCR), and the cell apoptosis rate was estimated by flow ... more

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Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and is considered essential for tumor growth and progression. However, the function of FOXO1 in human cervical cancer remains unclear. In this study, we investigated the role of FOXO1 in cervical cancer. Our results showed that FOXO1 expression was lower in cervical cancer than in cervical ... more

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Dysplasia prognosis factor; HPV viral load; Human papillomavirus

Persistent infection with human papillomavirus (HPV) has been recognized as the main etiological factor of morbimortality in cervical cancer. Several factors have been associated with the development of cervical disease, but viral load has recently been proposed as an indicator of cervical neoplasia. Therefore, a single measurement of viral load could be a suitable biomarker. We examined ... more

A.E. Bencomo-Álvarez; I. Limones-Perches; A.E. Suarez-Rincon; L.J. Ramírez-Jirano; E. Borrayo-Carbajal; J. Sánchez-Corona; H. Montoya-Fuentes
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We examined the prevalence of human papillomavirus (HPV) infection in a sample of Brazilian women presenting normal cervical cytology. Possible interactions between patient characteristics and HPV infection were analyzed in order to provide background data to improve cervical cancer screening and prophylaxis. Cervical samples of 399 women, received for routine evaluation in the Health ... more

P.M. Miranda; B.C.V. Pitol; M.S. Moran; N.N.T. Silva; P.M. Felix; J.L. Lima-Filho; C.M. Carneiro; I.D.C.G. Silva; R.F. Carvalho; A.A. Lima; W. Beçak; R.C. Stocco
10/31/2014
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We examined the prevalence of human papillomavirus (HPV) infection in Brazilian women with cervical intraepithelial neoplasia. Our goal was to identify the types of HPV and their association with risk factors. This prospective cross-sectional study included 97 samples collected from women aged 14-79 years at the public health units of gynecological care in São Luís, MA, Brazil. HPV ... more

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