Research Article

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01/29/2008
Ataxia; FMR1; FXTAS; Parkinsonism; Premutation; Tremor

A late onset neurological syndrome in carriers of premutation in FMR1 gene was recently described. The condition was named fragile-X-associated tremor/ataxia syndrome (FXTAS) and includes intentional tremor, cerebellar ataxia, parkinsonism, and cognitive deficit. We ascertained the contribution of FMR1 premutation to the phenotypes ataxia, tremor and/or parkinsonism. Sixty-six men over 45 ... more

A.H.O. Reis; A.C.S. Ferreira; K.B. Gomes; M.J.B. Aguiar; C.G. Fonseca; F.E. Cardoso; V.C. Pardini; M.R.S. Carvalho
10/03/2013
Animal model; Cyclin D1; Granulocyte macrophage colony generation; Jianpi Bushen Prescription; Radiation damage; Wnt3a

The effects of the traditional Chinese drug Jianpi Bushen Prescription (JBP) were investigated on expressions of Wnt3a and Cyclin D1 genes in radiation-damaged mice. The radiation damage model was induced in Kumming mice by single total body irradiation treatment for 9 days. Mice were divided into the radiation group, low-dose (100%) JBP group, high-dose (200%) JBP group ... more

D.C. He; J.J. Xiao; Y. Zhang; H. Lin; X.J. Ding; Y. Tu
02/17/2012
Animal model; Brain; Energy metabolism; Ethanol; Extended amygdala

We examined a possible relationship between genes responsible for energy metabolism of the brain and addictive behavior in an animal model. We used non-inbred, Swiss mice exposed to a three-bottle free-choice model [water, 5% (v/v) ethanol, and 10% (v/v) ethanol] over a 16-week period, consisting of four phases: acquisition, withdrawal, reexposure, and quinine-adulteration. The mice were ... more

A.F. Ribeiro; D. Correia; R. Boerngen-Lacerda; A.L. Brunialti-Godard
08/07/2014
Animal model; Bax; Bcl-2 gene; Chemical damage; Jianpi Bushen Prescription; SHP-1

We investigated the effect of Jianpi Bushen prescription (JBP) on the expression of the SHP-1 and apoptosis-related genes in chemically damaged model mice and a compound e-jiao slurry (EJS) group (positive control). Kunming mice received an abdominal injection of 100 mg/kg cyclophosphamide once a day for 3 consecutive days to induce chemical damage. The mice underwent lavage at a ... more

D.C. He; J.J. Xiao; Y. Zhang; H. Lin; X.J. Ding; Y. Tu
09/30/2005
Feature selection; Gene expression; Genetic algorithms; Microarrays; Multi-class SVM

Microarrays are a new technology that allows biologists to better understand the interactions between diverse pathologic state at the gene level. However, the amount of data generated by these tools becomes problematic, even though data are supposed to be automatically analyzed (e.g., for diagnostic purposes). The issue becomes more complex when the expression data involve multiple ... more

B.Feres de Souza; A.Ponce de L. de Carvalho
05/15/2013
Ex vivo expansion; Hematopoietic stem cell; Microarrays; Umbilical cord blood

The low number of hematopoietic stem cells (HSC) in umbilical cord blood (UCB) is directly related to increased risk of transplant failure. Effective ex vivo expansion of HSC has been tried for many years, with conflicting results because of the inability to reproduce in vitro HSC proliferation in the same way it occurs in vivo. We compared freshly isolated HSC ... more

D.L. Zanette; J.C.C. Lorenzi; R.A. Panepucci; A.R.D. Santos; G.A. Molfetta; A.G. Araujo; W.A.Silva Junior; M.A. Zago
09/05/2014
Broiler pigment; Expressed genes; Microarrays; Regulation mechanism of pigments

Chicken is an important model organism that unites the evolutionary gap between mammals and other vertebrates and provide major source of protein from meat and eggs for all over the world population. However, specific genes underlying the regulatory mechanism of broiler pigmentation have not yet been determined. In order to better understand the genes involved in the mechanism of ... more

T.M. Tarique; S. Yang; Z. Mohsina; J. Qiu; Z. Yan; G. Chen; A. Chen
05/18/2010
Animal model; Carcass yield; Heritability; Likelihood ratio test; Maternal effect

The effect of genetic and non-genetic factors for carcass, breast meat and leg weights, and yields of a commercial broiler line were investigated using the restricted maximum likelihood method, considering four different animal models, including or excluding maternal genetic effect with covariance between direct and maternal genetic effects, and maternal permanent environmental effect. ... more

J.L.B.M. Grosso; J.C.C. Balieiro; J.P. Eler; J.B.S. Ferraz; E.C. Mattos; M. Filho
07/07/2014
Allergic rhinitis; Aluminum adjuvant; Animal model; Colloid chemistry; Foreign body granuloma

This study evaluated different dosage forms of aluminum adjuvant in generating allergic rhinitis animal models. Forty female BALB/c mice were assigned to four groups, including three dosage forms of aluminum adjuvant [powder, gel, and hydrosolvent of aluminum hydroxide, Al(OH)3] mixed with ovalbumin to simulate the symptoms of allergic rhinitis and one control group. Although ... more

L. Xi; E. Fan; Y. Zhao; Y. Li; Y. Zhang; L. Zhang