Research Article

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03/20/2015
Angiotensin-converting enzyme; Coronary artery disease; Polymorphism

We investigated whether the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and serum ACE levels are associated with traditional risk factors of coronary artery disease (CAD). We enrolled 250 individuals without CAD and 750 individuals suffering from CAD who were angiographically diagnosed. Biochemical risk factors, the ACE (I/D) gene ... more

S. Sahin; K. Ceyhan; I. Benli; H. Ozyurt; E. Naseri; M.M. Tumuklu; L. Aydogan; A.O. Elalmis; A.F. Ozugurlu; O. Onalan
03/13/2015
Osteosarcoma; Polymorphism; RECQL5

In this study, we investigated the association between a RECQL genetic polymorphism and osteosarcoma in a Chinese population. We selected rs820196 in the RECQL5 gene and genotyped 185 patients with osteosarcoma and 201 age- and gender-matched non-cancer controls. We found that the CC genotype was more frequent in the osteosarcoma group compared to the control group (P = ... more

Y.Z. Dong; Y.X. Huang; T. Lu
03/13/2015
EGFR; ERBB1; Gastric cancer; Polymorphism

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with tyrosine-kinase activity that plays an important role in multiple cellular functions. EGFR overexpression has been observed in several types of tumors and it is significantly associated with disease stage, survival, prognosis, and progression of cancer. The polymorphisms -216G>T, -191C>A, and (CA)n ... more

J.H. Torres-Jasso; M.E. Marín; E. Santiago-Luna; J.C. Leoner; J. Torres; M.T. Magaña-Torres; F.J. Perea; B. Ibarra; J.Y. Sánchez-López
03/13/2015
Microsatellite markers; Pachycrepoideus vindemmiae; Polymorphism

The parasitoid wasp Pachycrepoideus vindemmiae (Rondani) is a common pupal parasitoid of many fly pests that is distributed worldwide. This organism can be used for biological control in orchards or livestock farms. Identifying polymorphic microsatellite loci would be useful for analyzing the population genetic structure of the parasitoid. In the current study, based on a ... more

W. Chen; L. Fang; J.L. Liu; Z. He; H.Y. Hu
03/13/2015
Gene; Liver X receptor α; Polymorphism; Stroke

We examined the relationship between the liver X receptor α gene (LXRα) polymorphism and the susceptibility to stroke. We utilized the single fluorescent-labeled probe technique to detect the genotype of rs12221497 in the LXRα gene in 400 stroke patients and 400 healthy control subjects. The difference in genotype distribution between the 2 groups was analyzed using the ... more

J.S. Yang; J.J. Hao; S.S. Wang; Z.F. Zhu; Q. Fang; H. Bao; H.P. Zhang
03/06/2015
Date palm; Genetic diversity; Microsatellite markers; Phoenix dactylifera L.; Polymorphism

The genetic diversity in the date palm germplasm of 59 female accessions representing 12 cultivars from different locations in Qatar was investigated using 14 loci of simple-sequence repeat (SSR) primers. A total of 94 alleles, with a mean of 6.7 alleles per locus, were scored. The number of alleles per locus varied from 3 (primer mPdCIR090) to 11 (primers mPdCIR010 and mPdCIR015). The ... more

K. Elmeer; I. Mattat
03/06/2015
Meta-analysis; Myocardial infarction; Polymorphism; TNF-β

Tumor necrosis factor-β (TNF-β) is an important mediator of inflammation and may play a role in the pathogenesis of myocardial infarction (MI). While several published studies have investigated the association between the C804A polymorphism in the TNF-β gene and MI risk, their results are controversial and ambiguous. In this study, we evaluated the contribution of the ... more

D.W. Suo; Q. Hu; J. Chen; Q.H. Sun; H. Guo
02/20/2015
Acute pancreatitis; Inflammatory cytokines; Polymorphism

We conducted a case-control study to clarify the asso­ciations between inflammatory cytokine, including interleukin (IL)-1b, IL-6, IL-8, and IL-10, polymorphisms and risk of acute pancreatitis. Genotyping analyses of IL-1β+3954 C/T (rs1143634), IL-1β-511 C/T (rs16944), IL-6 -174 G/C (rs1800795), IL-6 -634 C/G (rs1800796), IL-8 ... more

X.B. Bao; Z. Ma; J.B. Gu; X.Q. Wang; H.G. Li; W.Y. Wang
02/13/2015
Calpain (CAPN1); Chicken; Ligase detection reaction; Meat tenderness; Polymorphism

The micromolar calcium-activated neutral protease gene (CAPN1) is a physiological candidate gene for meat tenderness. Four previously identified single nucleotide polymorphism (SNP) markers located within the CAPN1 gene were evaluated for their associations with variation in the meat tenderness of a Chinese indigenous chicken breed, a higher meat quality breed (i.e., ... more

J.T. Shu; M. Zhang; Y.J. Shan; W.J. Xu; K.W. Chen; H.F. Li
02/13/2015
GSTM1; Lung cancer; Meta-analysis; Polymorphism

The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform literature ... more

H. Liu; H.F. Ma; Y.K. Chen

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