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Related GMR Articles

10/24/2013
Functional similarity; Gene set; miRNA; mRNA; Prostate cancer; Target gene

Annotation of prostate cancer (PC) genomes provides a foundation for discoveries that can improve the understanding and treatment of the disease. Therefore, in the present study, we used the Student t-test to identify differentially expressed PC-related mRNAs and microRNAs (miRNAs). Then, we performed interrelated mapping of miRNA target genes between abnormally expressed mRNAs ... more

H. Song; Y. Liu; J. Pan; S.T. Zhao
12/04/2014
Excision repair cross-complementing group 1; mRNA; Non-small cell lung cancer; Response to chemotherapy; Ribonucleotide reductase subunit M1; Survival

We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and clinical outcome ... more

H. Zhang; J. Li; Y. Zhang; M. Sun; P. Zhao; G. Zhang; C. Jin; L. Sun; M. He; B. Wang; X. Zhang
10/06/2008
meat quality; Pig; RH mapping

The suppressive subtractive hybridization technique was previously used by the authors to identify candidate genes for meat quality in pig. A set of ESTs homologous (>95%) to genes involved in muscle metabolism is reported in the present paper. Four ESTs homologous to MYH1, KALRN, MLC2V, and SNX13 genes plus two genes (AK1, PPIA) used as housekeeping for muscle tissue were assigned to ... more

C. Gorni; S. Iacuaniello; B. Castiglioni; G. Pagnacco; P. Mariani
09/04/2013
Glycogenin-1; Glycolytic potential; Muscle-fiber type; Myosin heavy chains; Pig

This study analyzed the effect of muscle-fiber type composition on glycogenin-1 (GYG) gene expression and its impact on pH. The longissimus dorsi (LD) muscle contains more type IIB fibers (75.10%) than does the psoas major (PM) muscle (41.58%), while the PM has more type I (3.65 vs 0.94%), type IIA (34.15 vs 10.63%), and type IIX (20.62 vs 13.33%) fibers. ... more

S.H. Zhang; L. Zhu; Z.H. Wu; Y. Zhang; G.Q. Tang; Y.Z. Jiang; M.Z. Li; L. Bai; X.W. Li
09/26/2012
DNA methylation; Fat; MSAP; Muscle; Pig

DNA methylation may be involved in regulating the expression of protein-coding genes, resulting in different fat and muscle phenotypes. Using a methylation-sensitive amplified polymorphism approach, we obtained 7423 bands by selective amplification of genomic DNA from six different fat depots and two heterogeneous muscle types from Duroc/Landrace/Yorkshire cross-bred pigs. The degrees of ... more

J.D. Ma; M.Z. Li; S.L. Zhou; C.W. Zhou; X.W. Li
07/24/2014
Apoptosis; Guanine nucleotide-binding protein; Pig; Thyroid gland

The Alpha subunit of the stimulatory guanine nucleotide-binding protein (GNAS) is a complex imprinted gene. The major product of the GNAS gene is the α-subunit of the guanine nucleotide-binding protein (Gas), which plays a key role in multiple signal transduction pathways. Gas is required for the production of the receptor-stimulated intracellular cyclic adenosine monophosphate ( ... more

J. Peng; Y.L. Li; Y.F. Shen; Y. Wang; N.Y. Xu
01/14/2014
Association analysis; Pig; Reproductive trait; RFRP gene; SNP

RFamide-related peptide (RFRP) gene is a crucial gene of the hypothalamo-pituitary-gonadal axis and plays an important role in reproduction regulation. This study aimed to clone and characterize the pig RFRP gene. We obtained a 645-bp cDNA of pig RFRP gene comprising a 546-bp open reading frame, which encoded a peptide of 188 amino acids. The pig RFRP coding ... more

M.X. Fang; Y.S. Huang; J. Ye; W. Zhang; Y. Li; Q.H. Nie
06/26/2015
Adipose tissue; Conjugated linoleic acid; Gene expression; MicroRNA; Pig

In this study, we evaluated the effect and possible mech­anism of action of dietary conjugated linoleic acid (CLA) on pig body fat deposition. Landrace piglets (N = 48) were randomly divided into three groups, which were fed diets containing 0% (control), 1%, or 2% CLA. Dorsal and abdominal subcutaneous adipose tissues were col­lected, and real-time polymerase chain reaction (PCR) was ... more

R.L. Qi; Y. Chen; J.X. Huang; F.Y. Yang
06/09/2015
BP1 gene; Combined genotype; Immune indices; Pig; Single nucleotide polymorphisms

The bactericidal/permeability-increasing protein (BPI) gene has been identified as a candidate gene for disease-resistance breeding. We evaluated whether polymorphisms in exons 4 and 10 of the BPI gene are associated with immune indices [interleukin-2 (IL-2), IL-4, IL-6, interferon-b (IFN-b), IL-10, and IL-12]. In this study, we identified one mutation (C522T) in the ... more

Z.C. Wu; Y. Liu; Q.H. Zhao; S.P. Zhu; Y.J. Huo; G.Q. Zhu; S.L. Wu; W.B. Bao
03/06/2015
Gene expression; Growth stages; Mitochondrial DNA copy number; Pig

Mitochondrial DNA (mtDNA) content is dependent on the energy requirements of tissues. To date, no comprehensive study has been conducted to examine mtDNA copy number variations in pigs. In the current study, quantitative polymerase chain reaction was performed to quantify the mtDNA copy number in 15 pig tissue types at 5 growth stages from embryo to adult. Observable differences in mtDNA ... more

Y.M. Xie; L. Jin; X.J. Chen; M.N. He; Y. Wang; R. Liu; M.Z. Li; X.W. Li

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