Research Article

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09/23/2013
EST-SSR; Grape vine; Polymorphism; Segregation

The objectives of this investigation were to develop and validate the expressed sequence tag (EST)-simple sequence repeat (SSR) markers from large EST sequences, and to study the segregation and distribution of SSRs within two grapevine parental lines. In total, 94 F1 lines crossed between "Early Rose" and "Red Globe" were studied. Approximately 2100 EST-SSR sequences of ... more

E. Kayesh; Y.Y. Zhang; G.S. Liu; N. Bilkish; X. Sun; X.P. Leng; J.G. Fang
09/03/2013
Genetic relationship; Lolium; Polymorphism; RAPD markers; Taxonomy

The genus Lolium is one of the most important groupings of temperate forage grasses, including about eight recognized species that are native to some temperate and subtropical regions of the northern hemisphere. We examined genetic relationships among 18 accessions representing all Lolium species using RAPD markers. Among 50 random primers that we screened, 13 gave ... more

X. Ma; X.Y. Gu; T.T. Chen; S.Y. Chen; L.K. Huang; X.Q. Zhang
07/15/2013
Leptin; Leptin receptor; Polymorphism; Preeclampsia

The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656Asn genotype and ... more

S. Wang; F.Y. Qiao; L. Feng
06/11/2013
GNAQ; Han Chinese population; Polymorphism; Rheumatoid arthritis

Mice that lose Gαq from their immune system can spontaneously develop inflammatory arthritis. Gαq expression in the peripheral blood lymphocytes of rheumatoid arthritis (RA) patients is significantly decreased in comparison to that in healthy individuals, and reduced Gαq expression is closely correlated with RA disease activ­ity. These indicate that Gαq plays critical roles in the ... more

Y. Li; Y. Wang; Y. He; D. Wang; L. Deng; Y. Du; G. Shi
03/15/2013
IL-18; Polymorphism; Prostate cancer

Interleukin-18 (IL-18) has been implicated in a wide variety of cellular functions that affect the biological response to tumors. However, there is insufficient evidence to prove that IL-18 gene variants are associated with risk of prostate cancer. We examined a possible association between two promoter polymorphisms, -137G/C (rs187238) and -607C/A (rs1946518), in the IL-18 ... more

J.M. Liu; J.N. Liu; M.T. Wei; Y.Z. He; Y. Zhou; X.B. Song; B.W. Ying; J. Huang
02/07/2013
Polymorphism; Rheumatoid arthritis; Toll-like receptor

We investigated whether Toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis and whether they influence clinical characteristics of rheumatoid arthritis. Studies were considered relevant for our meta-analysis if at least two comparisons of an issue were available. Eleven studies with 2078 patients with rheumatoid arthritis and 2581 controls were ... more

Y.H. Lee; S.C. Bae; G.G. Song
11/12/2012
Gastric cancer; Meta-analysis; Polymorphism; susceptibility; XRCC1

Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a ... more

B.M. Liu; T.M. Liu; B.S. You; H.Y. You; J. Yang; L. Li; Y.C. He
09/13/2012
GSTM1; Polymorphism; Primary open-angle glaucoma

Primary open-angle glaucoma (POAG) is characterized by loss of retinal ganglion cells, optic nerve damage and irreversible loss of visual field. Glaucoma is the second leading cause of blindness worldwide. It was estimated that in 2010 there were about 60.5 million glaucoma cases worldwide; among these patients, 4.5 million will become bilaterally blind. Glutathione S-transferases (GST) ... more

A.M. Barbosa; A.B. Frare; N.B. Costa; R.E. Silva; K.K.V.O. Moura
08/13/2012
Gastric cancer; Meta-analysis; NQO1 gene; Polymorphism; Risk

The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95% confidence interval (95 ... more

Y. Zhang; Z.T. Wang; J. Zhong
05/15/2012
5p15; Polymorphism; Prostate cancer

Recent evidence has suggested that single-nucleotide polymorphisms (SNPs) located at 5p15.33 contribute to susceptibilities for several cancer types, including prostate cancer. To determine whether SNP rs402710 in this region plays a role in prostate cancer, we analyzed these associations in a Chinese population; 251 prostate cancer patients and 273 control subjects were included in this ... more

Q. Ren; B. Xu; S.Q. Chen; Y. Yang; C.Y. Wang; Y.D. Wang; X.H. Wang; L.X. Hua; M. Chen

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