Research Article

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11/16/2010
CYP; GST; p53; Polymorphism; susceptibility; Thyroid disease

Specific genotypes appear to be related to the development of thyroid disease. We examined whether polymorphisms of the genes CYP1A1, GSTM1, GSTT1, and TP53 at codon 72 are associated with increased risk for thyroid nodules. Blood samples were obtained from 122 thyroid patients with nodules and from 134 healthy control individuals from Goiânia city, GO ... more

A.A.S. Reis; D.M. Silva; M.P. Curado; A.D. da Cruz
11/30/2010
Crustacean; Macrobrachium; Phylogenetic relathionship; Polymorphism; Prawn; RAPD-PCR

The prawn genus Macrobrachium belongs to the family Palaemonidae. Its species are widely distributed in lakes, reservoirs, floodplains, and rivers in tropical and subtropical regions of South America. Globally, the genus Macrobrachium includes nearly 210 known species, many of which have economic and ecological importance. We analyzed three species of this genus (M. ... more

A.L. Guerra; A.V.B. Lima; F.G. Taddei; L. Castiglioni
07/06/2010
Inner Mongolia; Metabolic lipid disorders; Polymorphism; PPARg2-Pro12Ala; Primary hypertension

In order to determine whether Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 (PPARγ2) gene contributes to susceptibility to primary hypertension and metabolic lipid disorders, 482 unrelated subjects from Inner Mongolia were studied, including 137 healthy normotensive (controls) and 345 hypertensive subjects. PCR-RFLP was used to determine the genotypes of ... more

L. Gao; L. Wang; H. Yun; L. Su; X. Su
07/27/2010
Biomphalaria; Genetic variability; Polymorphism; RAPD-PCR; Schistosoma mansoni

Despite the implementation control programs, schistosomiasis continues to spread throughout the world. Among modern control strategies, vector control is currently being emphasized. Within this context, analysis of the genetic variability of intermediate host snails (Biomphalaria spp) is important because it allows identification of specific sequences of the genome of this ... more

A.L.D. Oliveira; D. Da Silva; B.C. Manzano; A.Z. Abdel-Hamid; M.Y. Marcelino; E.M. Zanotti-Magalhães; E.M. Zanotti-Magalhães; L.A. Magalhães; J.T. Ribeiro-Paes
04/13/2010
Colorectal cancer; Kashmir; Polymorphism; Restriction digestion; RFLP; TP53

Two TP53 gene polymorphisms at codon 47 (TP53 Pro47Ser) and at codon 72 (TP53 Arg72Pro) have been associated with susceptibility to various cancers. We carried out a case-control study and examined the genotype distribution of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms (SNPs), using a PCR-RFLP approach, to determine if these two SNPs are ... more

A.S. Sameer; Z.A. Shah; N. Syeed; M.Z. Banday; S.M. Bashir; B.A. Bhat; M.A. Siddiqi
01/04/2013
Hepatocellular carcinoma; MIF-794CATT; Polymorphism; Promoter

Hepatocellular carcinoma (HCC) is one of the most common worldwide malignancies. A relative complete diagnosis system for primary carcinoma of liver has already been established, but the surgical prognosis for HCC, which depends mainly on postoperative pathological classification and data of recurrence and metastasis, lacks valid experimental indicators. Macrophage migration inhibition ... more

T. Yuan; C. Tang; M. Chen; S. Deng; P. Chen
12/13/2013
CCND1; Esophageal squamous cell carcinoma; Polymorphism; PTEN

Cyclin D1 (CCND1) plays a significant role in G1-S transition of cell cycle, and phosphatase and a tensin homologue (PTEN) negatively regulate cell cycle through phosphatidylinositol 3-kinase (PI3K)/AKT signaling. CCND1 and PTEN genetic polymorphisms might induce susceptibility to the occurrence of esophageal squamous cell carcinoma (ESCC). Three hundred and four ESCC patients and 413 ... more

Y. Jang; S.A. Lu; Z.P. Chen; J. Ma; C.Q. Xu; C.Z. Zhang; J.J. Wang
12/04/2013
Cluster; Fenugreek; Genetic diversity; Polymorphism; RFLP; SDS-PAGE

Protein and DNA polymorphismswere surveyed among seven accessions of wild fenugreek (Trigonellafoenum-graecum L.) to estimate their genetic diversity and relationships. Samples were obtained from diverse ecogeographical areas in Saudi Arabia and Yemen. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of seed storage protein showed genetic variations ... more

E.A. Haliem; A.A. Al-Huqail
02/28/2013
Ossification; Polymorphism; Posterior longitudinal ligament; Transforming growth factor-β1

Ossification of the posterior longitudinal ligaments (OPLL) has been considered to be associated with abnormalities of bone metabolism, and transforming growth factor-β1 (TGF-β1) has been demonstrated to affect the bone remodeling process. We investigated two SNPs of the TGF-β1 promoter (-509C>T; rs1800469) and exon 1 (869T>C; rs1982073) in 298 Koreans (98 patients with OPLL and ... more

I.B. Han; A.E. Ropper; Y.J. Jeon; H.S. Park; D.A. Shin; Y.D. Teng; S.U. Kuh; N.K. Kim
10/18/2013
NPP1; Ossification; Polymorphism; Posterior longitudinal ligament; Postoperative progression

Ossification of the posterior longitudinal ligament (OPLL) is a condition of the spine that can cause paralysis by compressing the spinal cord. The aim of this study was to evaluate the possible role of nucleotide pyrophosphatase phosphodiesterase 1 gene (NPP1) polymorphism in the etiology and pathology of the OPLL in Chinese patients. DNA from patients with OPLL (N = 95) and ... more

Z. He; H. Zhu; L. Ding; H. Xiao; D. Chen; F. Xue

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