Research Article

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04/06/2010
DNA repair; Endometriosis; Polymorphism; XRCC3 Thr/Thr

Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. We investigated the association of polymorphisms in the DNA repair genes XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys with endometriosis risk. Genotypes were determined by PCR-RFLP assays in 52 patients with endometriosis and 101 age- ... more

R. Attar; C. Cacina; S. Sozen; E. Attar; B. Agachan
04/02/2013
Endometriosis; Meta-analysis; Polymorphism; VEGF

Endometriosis is a chronic gynecological disease defined as the presence of the endometrium outside the uterine cavity. Endometriosis is a multifactorial and polygenic disease in which angiogenesis may be implicated. Angiogenesis is under the control of numerous inducers, including vascular endothelial growth factor (VEGF). Many studies have reported that VEGF plays a role in the ... more

Y.Z. Li; L.J. Wang; X. Li; S.L. Li; J.L. Wang; Z.H. Wu; L. Gong; X.D. Zhang
09/05/2014
Endometriosis; Epidermal growth factor; Polymorphism

The aim of this study was to verify the association between the epidermal growth factor (EGF) +61 G/A polymorphism and the susceptibility to endometriosis using a case-control design study. The control group included fertile women without endometriosis and the case group included endometriosis patients. Polymerase chain reaction-restriction fragment length polymorphism analysis ... more

C.B.N. Oliveira; P. Falagan-Lotsch; M.G. Souza; R.P. Santos; F. Encinas; H. Teles; R.B. Lasmar; L.B. Duarte; J.M. Granjeiro; I.A. Penna
08/02/2013
Endometriosis; GSTM1; GSTT1; Infertility

Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyzed the frequency of ... more

A.B. Frare; A.M. Barbosa; I.R. Costa; S.R. Souza; R.C.P.C. Silva; B.M. Bordin; C.L.Ribeiro Júnior; K.K.V.O. Moura
08/26/2014
Cell cycle; Endometriosis; Gene polymorphism; p53; TP53

We evaluated the association between TP53 gene polymorphisms and endometriosis in Brazilian women. Genomic DNA was extracted from swabs of buccal cells collected from hospital patients. TP53 gene polymorphisms were investigated at three codons: TP53*11 Glu/Gln or Lys (GAG->CAG or AAG), TP53*72 Arg/Pro (CCG->CCC), and TP53*248 Arg/Thr (CGG ... more

C.M. Camargo-Kosugi; P. D’Amora; J.P.F.O. Kleine; C.V. Carvalho; H. Sato; E. Schor; I.D.C.G. Silva
11/18/2013
-308G>A; Breast cancer; Mexican population; Obesity; Risk factor; Tumor necrosis factor alpha

The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with ... more

G. Flores-Ramos; E. De Dios; A.M. Puebla-Pérez; L.E. Figuera-Villanueva; A. Ramos-Silva; R. Ramírez-Patiño; J.I. Delgado-Saucedo; E. Salas-González; G.M. Zúñiga-González; A. Alonzo-Rojo; I. Gutiérrez-Hurtado; M.P. Gallegos-Arreola
02/14/2014
Colorectal cancer; Mexican population; MMP13; MMP7; Polymorphisms

Colorectal cancer (CRC) is characterized by enhanced expression and activity of several metalloproteinases (MMPs), including MMP13 and MMP7, which play an important role in tumor invasion and metastasis. The objective of this study was to analyze the association of functional MMP7-181A/G and MMP13-77A/G promoter polymorphisms with susceptibility to CRC ... more

J.M. Moreno-Ortiz; M. Gutierrez-Angulo; M. Partida-Pérez; J. Peregrina-Sandoval; R. Ramírez-Ramírez; R. Muñiz-Mendoza; S. Suárez-Villanueva; M. Centeno-Flores; V. Maciel-Gutiérrez; J.E. Cabrales-Vazquez; M.L. Ayala-Madrigal
04/27/2015
Breast cancer; C677T polymorphism; Mexican population; MTHFR

The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to ... more

A. Ramos-Silva; L.E. Figuera; O.M. Soto-Quintana; A.M. Puebla-Pérez; R. Ramírez-Patiño; I. Gutiérrez-Hurtado; D.I. Carrillo-Moreno; G.M. Zúñiga-González; I.P. Dávalos-Rodríguez; M.P. Gallegos-Arreola
09/18/2002
Brazil; Glutathione S-transferase; Polymorphism

The glutathione S-transferase (GST) family of enzymes has a vital role in phase II of biotransformation of environmental carcinogens, pollutants, drugs and other xenobiotics. GSTs are polymorphic, with the type and frequency of polymorphism being ethnic dependent. Polymorphisms in GST genes have been shown to be associated with susceptibility to disease and disease outcome. We ... more

A. Rossini; D.C.M. Rapozo; L.M.F. Amorim; J.M.B. Macedo; R. Medina; J.F.N. Neto; C.V.M. Gallo; L.F.R. Pinto
03/28/2007
Dog breeds; Growth; Polymorphism; SNP; SOCS2

Suppressor of cytokine signaling 2 (SOCS2) is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. In an effort to identify polymorphisms in the SOCS2 gene that may be associated with body size in dogs, we characterized the canine SOCS2 gene and analyzed its genetic diversity among small and large dog breeds ... more

G. Rincón; A.E. Young; D.L. Bannasch; J.F. Medrano

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